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Q6CSH0

- DNLI4_KLULA

UniProt

Q6CSH0 - DNLI4_KLULA

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Protein
DNA ligase 4
Gene
LIG4, KLLA0D01089g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining By similarity.

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei273 – 2731ATP By similarity
Active sitei275 – 2751N6-AMP-lysine intermediate By similarity
Binding sitei280 – 2801ATP By similarity
Binding sitei297 – 2971ATP By similarity
Metal bindingi333 – 3331Magnesium 1 Reviewed prediction
Metal bindingi438 – 4381Magnesium 2 Reviewed prediction
Binding sitei443 – 4431ATP By similarity
Binding sitei454 – 4541ATP By similarity
Binding sitei460 – 4601ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 4 (EC:6.5.1.1)
Alternative name(s):
DNA ligase IV
Polydeoxyribonucleotide synthase [ATP] 4
Gene namesi
Name:LIG4
Ordered Locus Names:KLLA0D01089g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 907907DNA ligase 4
PRO_0000278383Add
BLAST

Proteomic databases

PRIDEiQ6CSH0.

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CSH0.

Structurei

3D structure databases

ProteinModelPortaliQ6CSH0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini655 – 754100BRCT 1
Add
BLAST
Domaini800 – 906107BRCT 2
Add
BLAST

Sequence similaritiesi

Contains 2 BRCT domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000093622.
KOiK10777.
OMAiKMDGDRM.
OrthoDBiEOG7QC84G.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 2 hits.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CSH0-1 [UniParc]FASTAAdd to Basket

« Hide

MNDCENFSPS PEFKWLCDEL LGKIYETSSK KHLIGKPVTV RYLEIITNFI    50
KLWRSTVGNY IYPALRLIVP FRDRRIYNVK ENTLIKALCR YLRLPKSSET 100
ENRLLRWKQR AARGVKLSDF CVEEIRKRQK DYEGANRITI DELNGYLDEV 150
SQEGNGKRMG YMALTDSRAF NYCLNHMTFM EMKFFFDIIL KTRVLSGLEN 200
MFLTAWHPDA TDYLSVVSDL DVLSQRLYNP NERLRQTDLS ITISHAFEPQ 250
LAKRTHLSYE RVASKLQHDF IIEEKMDGER LQIHYINYGE QIKYLSRRGV 300
DFSYLYGENS SSGPISPSLK LHFNVKDCIL DGEMITYDTE KDIVLPFGLV 350
KSSAMNQIQS ELAGIAPTES YKPLFVAFDL VYLNGKSLTN LALERRKDYL 400
TKILTPVERS VEIIQYMKAI NAEAIKDSLE QAISMGSEGI VLKHLHSKYF 450
VGSRNTDWIK IKPEYLEQFG ENMDLLIIGR EQGKKDSFFC GLSISDPNEV 500
AEKPRFISFC TIANGLSNEE FKDIERKTWG KWHIFSEDPP SPNLLGFGTK 550
VPYEWIHPED SVVLEVKARA IDTKESEKRK YRSGCTLHFG YCKQIRYDKD 600
WKTVASFSEF EDMKDARNFY NKRKSHQVTD GKKRASKRAK IGIVNSSEPT 650
ALVAPVSNTF SNCRFRVISD YFDSTKRRRI SQEDLCSVIL EHGGEIVYTS 700
DENNLPQDNL YIIGEKLTRE CKILLNAKNL IIRPSWIFSC IEEGYKTPFT 750
ESDIFRGELE SSMDCSQFYT DFNTASLNHL LETANRGIKN PDSDLLLPEV 800
PLFLFSNLKL AVLNSENVLD TSILEVEFAI KCHGGELVHI ENASIIIVFN 850
DFISREDLFS LRQKIASKAV KESTESTPRI PRMVDISWAL DSIKDNYIAE 900
TEHYQCL 907
Length:907
Mass (Da):104,634
Last modified:August 16, 2004 - v1
Checksum:i1CE0987C0B4ADFDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382124 Genomic DNA. Translation: CAH00215.1.
RefSeqiXP_453119.1. XM_453119.1.

Genome annotation databases

GeneIDi2892937.
KEGGikla:KLLA0D01089g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382124 Genomic DNA. Translation: CAH00215.1 .
RefSeqi XP_453119.1. XM_453119.1.

3D structure databases

ProteinModelPortali Q6CSH0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 28985.Q6CSH0.

Proteomic databases

PRIDEi Q6CSH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2892937.
KEGGi kla:KLLA0D01089g.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000093622.
KOi K10777.
OMAi KMDGDRM.
OrthoDBi EOG7QC84G.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 2 hits.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiDNLI4_KLULA
AccessioniPrimary (citable) accession number: Q6CSH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi