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Q6CS21

- ATG18_KLULA

UniProt

Q6CS21 - ATG18_KLULA

Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.By similarity

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Autophagy, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 18
    Gene namesi
    Name:ATG18
    Ordered Locus Names:KLLA0D04664g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
    3. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Autophagy-related protein 18PRO_0000050867Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PI(3,5)P2 regulatory complex.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CS21.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CS21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati238 – 27841WD 1Add
    BLAST
    Repeati283 – 32240WD 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi279 – 2835FRRGT-motifBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi196 – 2016Poly-Gln

    Domaini

    The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
    The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

    Sequence similaritiesi

    Belongs to the WD repeat SVP1 family.Curated
    Contains 2 WD repeats.Curated

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG317564.
    HOGENOMiHOG000217543.
    KOiK17908.
    OMAiPLINEPT.
    OrthoDBiEOG7BW0V3.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 2 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 2 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6CS21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNLPIINFI NFNQNGSCIS MGTSQGFKIF NCEPFGRFYQ DEEGGCGIVE    50
    MLFSTSLLAV VGMGDNPAMS PRRLRMLNTK RHSVICEVTF PTTILSVKMN 100
    KSRLAVLLQE QIYIYDISNM RLLHTIETSM NAQGIMSMSP NSENNYLVYP 150
    SPPKVINSEI KDHATTNNIN IKKTDAVDDT IKKDYSLQVP SDITGQQQQQ 200
    QPGVDPATSN NTANKIIKNG DVIVFNLQTL QPTMVIEAHK GEIAALKLSA 250
    DGTLLATASE KGTIIRVFNV ENGSKVYQFR RGTYPTKISS LSFSKDNQFL 300
    AVCSSSKTVH IFKLGKNTVD NKSNELNSDD EIEDDLVPRY GDEDEEDEEI 350
    DEEATSINSN HSSKEPVVDA KRSTVGRMIR KSSQRLSRKA ARTLGAYFPI 400
    KVSSILEPSR HFASLKITTS SNQPIKAIAA IDDPIELSIK EYPDLFEKNA 450
    SNNGDYQNSD TLTMVPIRVV SSEGFMYKYI SDPERGGDCI LLEQYSLLSD 500
    Length:500
    Mass (Da):55,515
    Last modified:August 16, 2004 - v1
    Checksum:i1D276EE6EEE62C39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00364.1.
    RefSeqiXP_453268.1. XM_453268.1.

    Genome annotation databases

    GeneIDi2892881.
    KEGGikla:KLLA0D04664g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00364.1 .
    RefSeqi XP_453268.1. XM_453268.1.

    3D structure databases

    ProteinModelPortali Q6CS21.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CS21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2892881.
    KEGGi kla:KLLA0D04664g.

    Phylogenomic databases

    eggNOGi NOG317564.
    HOGENOMi HOG000217543.
    KOi K17908.
    OMAi PLINEPT.
    OrthoDBi EOG7BW0V3.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 2 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 2 hits.
    ProtoNeti Search...

    Entry informationi

    Entry nameiATG18_KLULA
    AccessioniPrimary (citable) accession number: Q6CS21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3