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Protein

Autophagy-related protein 18

Gene

ATG18

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 18
Gene namesi
Name:ATG18
Ordered Locus Names:KLLA0D04664g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598 Componenti: Chromosome D

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Autophagy-related protein 18PRO_0000050867Add
BLAST

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex.By similarity

Protein-protein interaction databases

STRINGi284590.XP_453268.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CS21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati238 – 27841WD 1Add
BLAST
Repeati283 – 32240WD 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi279 – 2835FRRGT-motifBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi196 – 2016Poly-Gln

Domaini

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity
The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG317564.
HOGENOMiHOG000217543.
InParanoidiQ6CS21.
KOiK17908.
OMAiHATTNNI.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q6CS21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLPIINFI NFNQNGSCIS MGTSQGFKIF NCEPFGRFYQ DEEGGCGIVE
60 70 80 90 100
MLFSTSLLAV VGMGDNPAMS PRRLRMLNTK RHSVICEVTF PTTILSVKMN
110 120 130 140 150
KSRLAVLLQE QIYIYDISNM RLLHTIETSM NAQGIMSMSP NSENNYLVYP
160 170 180 190 200
SPPKVINSEI KDHATTNNIN IKKTDAVDDT IKKDYSLQVP SDITGQQQQQ
210 220 230 240 250
QPGVDPATSN NTANKIIKNG DVIVFNLQTL QPTMVIEAHK GEIAALKLSA
260 270 280 290 300
DGTLLATASE KGTIIRVFNV ENGSKVYQFR RGTYPTKISS LSFSKDNQFL
310 320 330 340 350
AVCSSSKTVH IFKLGKNTVD NKSNELNSDD EIEDDLVPRY GDEDEEDEEI
360 370 380 390 400
DEEATSINSN HSSKEPVVDA KRSTVGRMIR KSSQRLSRKA ARTLGAYFPI
410 420 430 440 450
KVSSILEPSR HFASLKITTS SNQPIKAIAA IDDPIELSIK EYPDLFEKNA
460 470 480 490 500
SNNGDYQNSD TLTMVPIRVV SSEGFMYKYI SDPERGGDCI LLEQYSLLSD
Length:500
Mass (Da):55,515
Last modified:August 16, 2004 - v1
Checksum:i1D276EE6EEE62C39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA. Translation: CAH00364.1.
RefSeqiXP_453268.1. XM_453268.1.

Genome annotation databases

GeneIDi2892881.
KEGGikla:KLLA0D04664g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA. Translation: CAH00364.1.
RefSeqiXP_453268.1. XM_453268.1.

3D structure databases

ProteinModelPortaliQ6CS21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_453268.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2892881.
KEGGikla:KLLA0D04664g.

Phylogenomic databases

eggNOGiNOG317564.
HOGENOMiHOG000217543.
InParanoidiQ6CS21.
KOiK17908.
OMAiHATTNNI.
OrthoDBiEOG7BW0V3.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiATG18_KLULA
AccessioniPrimary (citable) accession number: Q6CS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.