Q6CS21 (ATG18_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 18

Gene names

Name:	ATG18
Ordered Locus Names:	KLLA0D04664g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and autophagy By similarity.
Subcellular location	Preautophagosomal structure membrane; Peripheral membrane protein By similarity. Vacuole membrane; Peripheral membrane protein By similarity. Note: Peripheral membrane protein of pre-autophagosomal structure (PAS) and vacuole By similarity.
Sequence similarities	Belongs to the WD repeat SVP1 family. Contains 2 WD repeats.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Membrane Vacuole
Domain	Repeat WD repeat
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	pre-autophagosomal structure membrane Inferred from electronic annotation. Source: UniProtKB-SubCell vacuolar membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Autophagy-related protein 18		PRO_0000050867
Regions
	Repeat	238 – 278	41	WD 1
	Repeat	283 – 322	40	WD 2
	Compositional bias	196 – 201	6	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	Q6CS21 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 1D276EE6EEE62C39	FASTA	500	55,515
	10 20 30 40 50 60 MSNLPIINFI NFNQNGSCIS MGTSQGFKIF NCEPFGRFYQ DEEGGCGIVE MLFSTSLLAV 70 80 90 100 110 120 VGMGDNPAMS PRRLRMLNTK RHSVICEVTF PTTILSVKMN KSRLAVLLQE QIYIYDISNM 130 140 150 160 170 180 RLLHTIETSM NAQGIMSMSP NSENNYLVYP SPPKVINSEI KDHATTNNIN IKKTDAVDDT 190 200 210 220 230 240 IKKDYSLQVP SDITGQQQQQ QPGVDPATSN NTANKIIKNG DVIVFNLQTL QPTMVIEAHK 250 260 270 280 290 300 GEIAALKLSA DGTLLATASE KGTIIRVFNV ENGSKVYQFR RGTYPTKISS LSFSKDNQFL 310 320 330 340 350 360 AVCSSSKTVH IFKLGKNTVD NKSNELNSDD EIEDDLVPRY GDEDEEDEEI DEEATSINSN 370 380 390 400 410 420 HSSKEPVVDA KRSTVGRMIR KSSQRLSRKA ARTLGAYFPI KVSSILEPSR HFASLKITTS 430 440 450 460 470 480 SNQPIKAIAA IDDPIELSIK EYPDLFEKNA SNNGDYQNSD TLTMVPIRVV SSEGFMYKYI 490 500 SDPERGGDCI LLEQYSLLSD

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382124 Genomic DNA. Translation: CAH00364.1.
RefSeq	XP_453268.1. XM_453268.1.
3D structure databases
ProteinModelPortal	Q6CS21.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CS21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2892881.
KEGG	kla:KLLA0D04664g.
Phylogenomic databases
eggNOG	NOG317564.
HOGENOM	HOG000217543.
OMA	RGGDCIL.
OrthoDB	EOG4M0J97.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 2 hits. [Graphical view]
SMART	SM00320. WD40. 2 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG18_KLULA

Accession

Primary (citable) accession number: Q6CS21

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program