Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6CS21 (ATG18_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy-related protein 18
Gene names
Name:ATG18
Ordered Locus Names:KLLA0D04664g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication By similarity.

Subunit structure

Component of the PI(3,5)P2 regulatory complex By similarity.

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein By similarity. Vacuole membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.

Domain

The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane By similarity.

The FRRGT-motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions By similarity.

Sequence similarities

Belongs to the WD repeat SVP1 family.

Contains 2 WD repeats.

Ontologies

Keywords
   Biological processAutophagy
Protein transport
Transport
   Cellular componentEndosome
Membrane
Vacuole
   DomainRepeat
WD repeat
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

pre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Autophagy-related protein 18
PRO_0000050867

Regions

Repeat238 – 27841WD 1
Repeat283 – 32240WD 2
Motif279 – 2835FRRGT-motif By similarity
Compositional bias196 – 2016Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
Q6CS21 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1D276EE6EEE62C39

FASTA50055,515
        10         20         30         40         50         60 
MSNLPIINFI NFNQNGSCIS MGTSQGFKIF NCEPFGRFYQ DEEGGCGIVE MLFSTSLLAV 

        70         80         90        100        110        120 
VGMGDNPAMS PRRLRMLNTK RHSVICEVTF PTTILSVKMN KSRLAVLLQE QIYIYDISNM 

       130        140        150        160        170        180 
RLLHTIETSM NAQGIMSMSP NSENNYLVYP SPPKVINSEI KDHATTNNIN IKKTDAVDDT 

       190        200        210        220        230        240 
IKKDYSLQVP SDITGQQQQQ QPGVDPATSN NTANKIIKNG DVIVFNLQTL QPTMVIEAHK 

       250        260        270        280        290        300 
GEIAALKLSA DGTLLATASE KGTIIRVFNV ENGSKVYQFR RGTYPTKISS LSFSKDNQFL 

       310        320        330        340        350        360 
AVCSSSKTVH IFKLGKNTVD NKSNELNSDD EIEDDLVPRY GDEDEEDEEI DEEATSINSN 

       370        380        390        400        410        420 
HSSKEPVVDA KRSTVGRMIR KSSQRLSRKA ARTLGAYFPI KVSSILEPSR HFASLKITTS 

       430        440        450        460        470        480 
SNQPIKAIAA IDDPIELSIK EYPDLFEKNA SNNGDYQNSD TLTMVPIRVV SSEGFMYKYI 

       490        500 
SDPERGGDCI LLEQYSLLSD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382124 Genomic DNA. Translation: CAH00364.1.
RefSeqXP_453268.1. XM_453268.1.

3D structure databases

ProteinModelPortalQ6CS21.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CS21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892881.
KEGGkla:KLLA0D04664g.

Phylogenomic databases

eggNOGNOG317564.
HOGENOMHOG000217543.
KOK17908.
OMAPLINEPT.
OrthoDBEOG7BW0V3.

Family and domain databases

Gene3D2.130.10.10. 2 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 2 hits.
[Graphical view]
SMARTSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 2 hits.
ProtoNetSearch...

Entry information

Entry nameATG18_KLULA
AccessionPrimary (citable) accession number: Q6CS21
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families