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Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841ATPPROSITE-ProRule annotation
Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:KLLA0D10527g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645Serine/threonine-protein kinase BUR1PRO_0000085684Add
BLAST

Proteomic databases

PRIDEiQ6CRA9.

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CRA9.

Structurei

3D structure databases

ProteinModelPortaliQ6CRA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 379325Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6CRA9.
KOiK15562.
OMAiNEECHES.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CRA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVNKKPAS LKYKIGKVKQ IPTVVKDDKT GLEYIQVQSR ENEKVYGVTK
60 70 80 90 100
FLNNYREEEK LGQGTFGEVF KGIHLGTNRK VAIKRILVRA EKDLFPITAQ
110 120 130 140 150
REITILKRMN HKNIVKLIEI VYDESPTPKT DSTSPRPVGN YHGNNTANQQ
160 170 180 190 200
KLITGKHFFM ILPYMVSDLT GLLHNPRVEF GMADVKNIML QLLEGINYIH
210 220 230 240 250
CNKFLHRDIK TANILIDHKG VVKIADFGLA RNYYGSPPNL KYPGGAGSGA
260 270 280 290 300
KYTSVVVTRW YRAPEIVLGD RHYTTAVDIW GIGCVFAEFF EKKPILQGQT
310 320 330 340 350
DIDQGHVIFK LMGTPSMDEW GLAYHLPGSE LTKTNYKSTL QERFSKALNE
360 370 380 390 400
TGLDLLSKLL ALDPYKRVTA MKAKKHPFFF EEPLPNAQLT LPNEECHESD
410 420 430 440 450
IKRYKSEMNE SMSQRPPSAP TGHTSTDNSI RAVTGAAFPK EASIPKAPRP
460 470 480 490 500
EHIKSTIPAQ PSASRYNGAA TQNIPKEPIP TAPLPKGPKN SIPTGPNKLP
510 520 530 540 550
PNPRDSYASK YPAESRFGVN TRITTESYNA GKRYRNRGGW ETGRDSLNYN
560 570 580 590 600
NNYAPPADRS HHPTIQRPSA PRGGSYPNRY QNQDYNTSRN TGYNQYSQAG
610 620 630 640
DRRSYRPGAS ENPGTIGHGS SQSTQKDSKS SHSNNVKPKD VADYY
Length:645
Mass (Da):72,214
Last modified:August 16, 2004 - v1
Checksum:iDB586D142DD0FBC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA. Translation: CAH00626.1.
RefSeqiXP_453530.1. XM_453530.1.

Genome annotation databases

GeneIDi2893554.
KEGGikla:KLLA0D10527g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA. Translation: CAH00626.1.
RefSeqiXP_453530.1. XM_453530.1.

3D structure databases

ProteinModelPortaliQ6CRA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CRA9.

Proteomic databases

PRIDEiQ6CRA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2893554.
KEGGikla:KLLA0D10527g.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6CRA9.
KOiK15562.
OMAiNEECHES.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUR1_KLULA
AccessioniPrimary (citable) accession number: Q6CRA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.