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Q6CRA9 (BUR1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase BUR1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:BUR1
Ordered Locus Names:KLLA0D10527g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length645 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 645645Serine/threonine-protein kinase BUR1
PRO_0000085684

Regions

Domain55 – 379325Protein kinase
Nucleotide binding61 – 699ATP By similarity

Sites

Active site2081Proton acceptor By similarity
Binding site841ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CRA9 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: DB586D142DD0FBC8

FASTA64572,214
        10         20         30         40         50         60 
MSTVNKKPAS LKYKIGKVKQ IPTVVKDDKT GLEYIQVQSR ENEKVYGVTK FLNNYREEEK 

        70         80         90        100        110        120 
LGQGTFGEVF KGIHLGTNRK VAIKRILVRA EKDLFPITAQ REITILKRMN HKNIVKLIEI 

       130        140        150        160        170        180 
VYDESPTPKT DSTSPRPVGN YHGNNTANQQ KLITGKHFFM ILPYMVSDLT GLLHNPRVEF 

       190        200        210        220        230        240 
GMADVKNIML QLLEGINYIH CNKFLHRDIK TANILIDHKG VVKIADFGLA RNYYGSPPNL 

       250        260        270        280        290        300 
KYPGGAGSGA KYTSVVVTRW YRAPEIVLGD RHYTTAVDIW GIGCVFAEFF EKKPILQGQT 

       310        320        330        340        350        360 
DIDQGHVIFK LMGTPSMDEW GLAYHLPGSE LTKTNYKSTL QERFSKALNE TGLDLLSKLL 

       370        380        390        400        410        420 
ALDPYKRVTA MKAKKHPFFF EEPLPNAQLT LPNEECHESD IKRYKSEMNE SMSQRPPSAP 

       430        440        450        460        470        480 
TGHTSTDNSI RAVTGAAFPK EASIPKAPRP EHIKSTIPAQ PSASRYNGAA TQNIPKEPIP 

       490        500        510        520        530        540 
TAPLPKGPKN SIPTGPNKLP PNPRDSYASK YPAESRFGVN TRITTESYNA GKRYRNRGGW 

       550        560        570        580        590        600 
ETGRDSLNYN NNYAPPADRS HHPTIQRPSA PRGGSYPNRY QNQDYNTSRN TGYNQYSQAG 

       610        620        630        640 
DRRSYRPGAS ENPGTIGHGS SQSTQKDSKS SHSNNVKPKD VADYY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382124 Genomic DNA. Translation: CAH00626.1.
RefSeqXP_453530.1. XM_453530.1.

3D structure databases

ProteinModelPortalQ6CRA9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CRA9.

Proteomic databases

PRIDEQ6CRA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893554.
KEGGkla:KLLA0D10527g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK15562.
OMANSECAGS.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_KLULA
AccessionPrimary (citable) accession number: Q6CRA9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families