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Q6CRA9

- BUR1_KLULA

UniProt

Q6CRA9 - BUR1_KLULA

Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.
    ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841ATPPROSITE-ProRule annotation
    Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi61 – 699ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:BUR1
    Ordered Locus Names:KLLA0D10527g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 645645Serine/threonine-protein kinase BUR1PRO_0000085684Add
    BLAST

    Proteomic databases

    PRIDEiQ6CRA9.

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CRA9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CRA9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 379325Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK15562.
    OMAiNSECAGS.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CRA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVNKKPAS LKYKIGKVKQ IPTVVKDDKT GLEYIQVQSR ENEKVYGVTK    50
    FLNNYREEEK LGQGTFGEVF KGIHLGTNRK VAIKRILVRA EKDLFPITAQ 100
    REITILKRMN HKNIVKLIEI VYDESPTPKT DSTSPRPVGN YHGNNTANQQ 150
    KLITGKHFFM ILPYMVSDLT GLLHNPRVEF GMADVKNIML QLLEGINYIH 200
    CNKFLHRDIK TANILIDHKG VVKIADFGLA RNYYGSPPNL KYPGGAGSGA 250
    KYTSVVVTRW YRAPEIVLGD RHYTTAVDIW GIGCVFAEFF EKKPILQGQT 300
    DIDQGHVIFK LMGTPSMDEW GLAYHLPGSE LTKTNYKSTL QERFSKALNE 350
    TGLDLLSKLL ALDPYKRVTA MKAKKHPFFF EEPLPNAQLT LPNEECHESD 400
    IKRYKSEMNE SMSQRPPSAP TGHTSTDNSI RAVTGAAFPK EASIPKAPRP 450
    EHIKSTIPAQ PSASRYNGAA TQNIPKEPIP TAPLPKGPKN SIPTGPNKLP 500
    PNPRDSYASK YPAESRFGVN TRITTESYNA GKRYRNRGGW ETGRDSLNYN 550
    NNYAPPADRS HHPTIQRPSA PRGGSYPNRY QNQDYNTSRN TGYNQYSQAG 600
    DRRSYRPGAS ENPGTIGHGS SQSTQKDSKS SHSNNVKPKD VADYY 645
    Length:645
    Mass (Da):72,214
    Last modified:August 16, 2004 - v1
    Checksum:iDB586D142DD0FBC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00626.1.
    RefSeqiXP_453530.1. XM_453530.1.

    Genome annotation databases

    GeneIDi2893554.
    KEGGikla:KLLA0D10527g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00626.1 .
    RefSeqi XP_453530.1. XM_453530.1.

    3D structure databases

    ProteinModelPortali Q6CRA9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CRA9.

    Proteomic databases

    PRIDEi Q6CRA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2893554.
    KEGGi kla:KLLA0D10527g.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K15562.
    OMAi NSECAGS.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiBUR1_KLULA
    AccessioniPrimary (citable) accession number: Q6CRA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3