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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei211ATPPROSITE-ProRule annotation1
Active sitei312Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 104ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
KlSRB10
Gene namesi
Name:SSN3
Synonyms:CDK8, SRB10
Ordered Locus Names:KLLA0D11814g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129461 – 593Serine/threonine-protein kinase SSN3Add BLAST593

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi284590.XP_453588.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CR51.
SMRiQ6CR51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 489Protein kinasePROSITE-ProRule annotationAdd BLAST400

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi516 – 555Asn-richAdd BLAST40
Compositional biasi560 – 570Ala-richAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ6CR51.
KOiK02208.
OMAiIMWQILD.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CR51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGNQQNNSN PYQMSYYRMN NGQGQGTNRW PQQLSHQEML AGHSQQILNN
60 70 80 90 100
NKPAGNQSKP PIVMASNNVF SIGPYRQRKD SSRISVLQKY EIIGYIAAGT
110 120 130 140 150
YGKVYKAKAR DYQNGMNRDN VIILDSPDSV SADSNLDINS INRSTRQQEA
160 170 180 190 200
NDNLTTMDFR KPSHKRFTPP NNSNSTQIRS NSGSETNVRI NSSSITNNSR
210 220 230 240 250
KPSQIQFYAI KKFKTEREGV EHYTGISQSA CREMSLCREL DNNHLTKLVE
260 270 280 290 300
IFLEKKSIYM VSEFAEHDLL QIIHFHSHPE KRLIPPRMLK SIMWQILDGV
310 320 330 340 350
SYLHQNWILH RDLKPANIMV TVDGCVKIGD LGLARKFNNM VQTLYTGDKV
360 370 380 390 400
IVTIWYRAPE LILGARHYTP AIDLWAVGCI FAELIGLRPI FKGEEAKMES
410 420 430 440 450
KKSVLFQANQ FQKILEVMGS PDHKIWPNID SYPEYLQLAK MPKYRDNLTA
460 470 480 490 500
WYQTAGGKDK TALDILYRLL QYDPIKRIDA IDALDHVYFT NGDPPVCENV
510 520 530 540 550
FEGLNYKYPP RRIHTNDNDI TNVGNDNNQA NHSQKQPMHG NNNNKNGNMN
560 570 580 590
GLGVNKRILA AAAAAAAAAA VSGNGNNPTS NTATGGSARK KRK
Length:593
Mass (Da):67,013
Last modified:August 16, 2004 - v1
Checksum:i4B4CC0E3731164BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50N → T in CAD58722 (PubMed:15116433).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ532841 Genomic DNA. Translation: CAD58722.1.
CR382124 Genomic DNA. Translation: CAH00684.1.
RefSeqiXP_453588.1. XM_453588.1.

Genome annotation databases

EnsemblFungiiCAH00684; CAH00684; KLLA0_D11814g.
GeneIDi2892704.
KEGGikla:KLLA0D11814g.

Similar proteinsi

Entry informationi

Entry nameiSSN3_KLULA
AccessioniPrimary (citable) accession number: Q6CR51
Secondary accession number(s): Q70W23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families