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Q6CR51 (SSN3_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
KlSRB10
Gene names
Name:SSN3
Synonyms:CDK8, SRB10
Ordered Locus Names:KLLA0D11814g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 593593Serine/threonine-protein kinase SSN3
PRO_0000312946

Regions

Domain90 – 489400Protein kinase
Nucleotide binding96 – 1049ATP By similarity
Compositional bias516 – 55540Asn-rich
Compositional bias560 – 57011Ala-rich

Sites

Active site3121Proton acceptor By similarity
Binding site2111ATP By similarity

Experimental info

Sequence conflict501N → T in CAD58722. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6CR51 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 4B4CC0E3731164BC

FASTA59367,013
        10         20         30         40         50         60 
MYGNQQNNSN PYQMSYYRMN NGQGQGTNRW PQQLSHQEML AGHSQQILNN NKPAGNQSKP 

        70         80         90        100        110        120 
PIVMASNNVF SIGPYRQRKD SSRISVLQKY EIIGYIAAGT YGKVYKAKAR DYQNGMNRDN 

       130        140        150        160        170        180 
VIILDSPDSV SADSNLDINS INRSTRQQEA NDNLTTMDFR KPSHKRFTPP NNSNSTQIRS 

       190        200        210        220        230        240 
NSGSETNVRI NSSSITNNSR KPSQIQFYAI KKFKTEREGV EHYTGISQSA CREMSLCREL 

       250        260        270        280        290        300 
DNNHLTKLVE IFLEKKSIYM VSEFAEHDLL QIIHFHSHPE KRLIPPRMLK SIMWQILDGV 

       310        320        330        340        350        360 
SYLHQNWILH RDLKPANIMV TVDGCVKIGD LGLARKFNNM VQTLYTGDKV IVTIWYRAPE 

       370        380        390        400        410        420 
LILGARHYTP AIDLWAVGCI FAELIGLRPI FKGEEAKMES KKSVLFQANQ FQKILEVMGS 

       430        440        450        460        470        480 
PDHKIWPNID SYPEYLQLAK MPKYRDNLTA WYQTAGGKDK TALDILYRLL QYDPIKRIDA 

       490        500        510        520        530        540 
IDALDHVYFT NGDPPVCENV FEGLNYKYPP RRIHTNDNDI TNVGNDNNQA NHSQKQPMHG 

       550        560        570        580        590 
NNNNKNGNMN GLGVNKRILA AAAAAAAAAA VSGNGNNPTS NTATGGSARK KRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ532841 Genomic DNA. Translation: CAD58722.1.
CR382124 Genomic DNA. Translation: CAH00684.1.
RefSeqXP_453588.1. XM_453588.1.

3D structure databases

ProteinModelPortalQ6CR51.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CR51.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2892704.
KEGGkla:KLLA0D11814g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02208.
OMAFHSHPEK.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_KLULA
AccessionPrimary (citable) accession number: Q6CR51
Secondary accession number(s): Q70W23
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families