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Protein

Mitochondrial thiamine pyrophosphate carrier 1

Gene

TPC1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial thiamine pyrophosphate carrier 1
Gene namesi
Name:TPC1
Ordered Locus Names:KLLA0D15015g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome D

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 37Helical; Name=1Sequence analysisAdd BLAST23
Transmembranei80 – 100Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei168 – 190Helical; Name=4Sequence analysisAdd BLAST23
Transmembranei205 – 227Helical; Name=5Sequence analysisAdd BLAST23
Transmembranei281 – 300Helical; Name=6Sequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003204661 – 317Mitochondrial thiamine pyrophosphate carrier 1Add BLAST317

Structurei

3D structure databases

ProteinModelPortaliQ6CQR3.
SMRiQ6CQR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati16 – 103Solcar 1Add BLAST88
Repeati112 – 197Solcar 2Add BLAST86
Repeati206 – 306Solcar 3Add BLAST101

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0752. Eukaryota.
ENOG410ZRF1. LUCA.
HOGENOMiHOG000165726.
InParanoidiQ6CQR3.
KOiK15108.
OMAiWKGNVPA.
OrthoDBiEOG092C3KDM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom_sf.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6CQR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTGIRKDHL RKGETVSWYN SVIAGSVSGV FARMATAPMD TVKIRYQLQP
60 70 80 90 100
VQEDKYKGIA STVRTIMKEE GLRALWKGNI PATAMYVVYG AVQFGSYSWF
110 120 130 140 150
NNVWSAKFPR FSQQGQTLTV GALAGMTSSV VSYPLDLLRT RLIANRTSHR
160 170 180 190 200
TSVAEECRQM WLNEGVRGFF TGISTAMTTV TLSTAIMFLT YETVNIVCEN
210 220 230 240 250
HEKEFWSRPV SASSGIIAGF VSKTMVFPID TLRRRMQVMN SKRTVHFTKF
260 270 280 290 300
PAVYHEYRYK SSTAIIYKIL RQEGVSALYR GLTMGLCKSV PTTAISLFVY
310
ERTMDLFDHG QRWGRSP
Length:317
Mass (Da):35,841
Last modified:August 16, 2004 - v1
Checksum:i7005F84BCF5E360E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382124 Genomic DNA. Translation: CAH00822.1.
RefSeqiXP_453726.1. XM_453726.1.

Genome annotation databases

EnsemblFungiiCAH00822; CAH00822; KLLA0_D15015g.
GeneIDi2893179.
KEGGikla:KLLA0D15015g.

Similar proteinsi

Entry informationi

Entry nameiTPC1_KLULA
AccessioniPrimary (citable) accession number: Q6CQR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families