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Q6CQN7 (DUT_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:DUT1
Ordered Locus Names:KLLA0D15697g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processdUMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

dUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 148148Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182933

Regions

Region68 – 703Substrate binding By similarity
Region82 – 854Substrate binding By similarity
Region142 – 1432Substrate binding By similarity

Sites

Binding site931Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1371Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CQN7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: E835B04A810A3DD3

FASTA14815,534
        10         20         30         40         50         60 
MTESLSNSLK VQLRSADAKV PTKGSTTAAG YDIYASQPGV IPARGQGIAK TDISFTVPVG 

        70         80         90        100        110        120 
TYGRIAPRSG LAVKHGIQTG AGVVDRDYTG EVGIVLFNHS DKDFQINKGD RVAQLILEKI 

       130        140 
VEDAEIVVVE SLEETQRGAG GFGSTGKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382124 Genomic DNA. Translation: CAH00848.1.
RefSeqXP_453752.1. XM_453752.1.

3D structure databases

ProteinModelPortalQ6CQN7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CQN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893442.
KEGGkla:KLLA0D15697g.

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHOG000028966.
KOK01520.
OMAAVKHGIQ.
OrthoDBEOG7T7H6C.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDUT_KLULA
AccessionPrimary (citable) accession number: Q6CQN7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways