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Q6CQL7

- HIS4_KLULA

UniProt

Q6CQL7 - HIS4_KLULA

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

HIS6

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

    Pathwayi

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
    Alternative name(s):
    5-proFAR isomerase
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
    Gene namesi
    Name:HIS6
    Ordered Locus Names:KLLA0D16148g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2672671-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141959Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CQL7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CQL7.
    SMRiQ6CQL7. Positions 2-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.Curated

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000172261.
    KOiK01814.
    OMAiFVAMNKW.
    OrthoDBiEOG7ZWDC9.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PANTHERiPTHR21169. PTHR21169. 1 hit.
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6CQL7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKFVGCIDL HDGQVKQIVG GTLTDSSKDK VTTNFVSKLP PSHYAKLYHE    50
    NQVEGCHVIK LGPNNDEAAL EALNECPNFL QVGGGITLDN CGYWLKYASK 100
    IIVTSFLFDK STYQFQREKL VKLAEICGKD RLVVDLSCKR VTKPDQEPKW 150
    VVAMNKWQTL TDLELNERTF ADLCQYTDEF LVHAADVEGL CNGIDEELVA 200
    HLYKWTADIP KVKIVYAGGA KSVDDLRLVE KLSHGKIDLT FGSALDIFGG 250
    SLVKFEDCVQ WNHEKHA 267
    Length:267
    Mass (Da):29,913
    Last modified:August 16, 2004 - v1
    Checksum:i6A75F855853C6FA7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00868.1.
    RefSeqiXP_453772.1. XM_453772.1.

    Genome annotation databases

    GeneIDi2893434.
    KEGGikla:KLLA0D16148g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH00868.1 .
    RefSeqi XP_453772.1. XM_453772.1.

    3D structure databases

    ProteinModelPortali Q6CQL7.
    SMRi Q6CQL7. Positions 2-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CQL7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2893434.
    KEGGi kla:KLLA0D16148g.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000172261.
    KOi K01814.
    OMAi FVAMNKW.
    OrthoDBi EOG7ZWDC9.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR011858. HisA_euk.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    PANTHERi PTHR21169. PTHR21169. 1 hit.
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiHIS4_KLULA
    AccessioniPrimary (citable) accession number: Q6CQL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3