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Q6CQ61

- SSU72_KLULA

UniProt

Q6CQ61 - SSU72_KLULA

Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
    Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    mRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
    Short name:
    CTD phosphatase SSU72
    Alternative name(s):
    Suppressor of SUA7 protein 2 homolog
    Gene namesi
    Name:SSU72
    Ordered Locus Names:KLLA0D19514g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome D

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255610Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CQ61.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CQ61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SSU72 phosphatase family.Curated

    Phylogenomic databases

    eggNOGiCOG5211.
    HOGENOMiHOG000183445.
    KOiK15544.
    OMAiWQERWPN.
    OrthoDBiEOG7GTTG0.

    Family and domain databases

    InterProiIPR006811. RNA_pol_II_suA.
    [Graphical view]
    PANTHERiPTHR20383. PTHR20383. 1 hit.
    PfamiPF04722. Ssu72. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CQ61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESMRNSGL KFCTVCASNN NRSMESHRVL EEAGYDVSSY GTGSAVRLPG    50
    LSIDKPNVYS FGTPYDDIYN DLISQSEDRY KQNGVLEMLD RNRKLKKAPE 100
    KWHDGRKVFD FVFTCEERCF DSVCEDLMNR GGQLNLIAHI INIDIKDDNE 150
    NAKIGGRAIL RLADMLRDKV FECEKNGTQF EDFIMDVFTE WQEKYPKLPL 200
    TYSAAYY 207
    Length:207
    Mass (Da):23,838
    Last modified:August 16, 2004 - v1
    Checksum:i8E050E3873B90B6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH01024.1.
    RefSeqiXP_453928.1. XM_453928.1.

    Genome annotation databases

    GeneIDi2893209.
    KEGGikla:KLLA0D19514g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382124 Genomic DNA. Translation: CAH01024.1 .
    RefSeqi XP_453928.1. XM_453928.1.

    3D structure databases

    ProteinModelPortali Q6CQ61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CQ61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2893209.
    KEGGi kla:KLLA0D19514g.

    Phylogenomic databases

    eggNOGi COG5211.
    HOGENOMi HOG000183445.
    KOi K15544.
    OMAi WQERWPN.
    OrthoDBi EOG7GTTG0.

    Family and domain databases

    InterProi IPR006811. RNA_pol_II_suA.
    [Graphical view ]
    PANTHERi PTHR20383. PTHR20383. 1 hit.
    Pfami PF04722. Ssu72. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiSSU72_KLULA
    AccessioniPrimary (citable) accession number: Q6CQ61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3