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Q6CQ61

- SSU72_KLULA

UniProt

Q6CQ61 - SSU72_KLULA

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Protein

RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Gene

SSU72

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).By similarity
Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (EC:3.1.3.16)
Short name:
CTD phosphatase SSU72
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene namesi
Name:SSU72
Ordered Locus Names:KLLA0D19514g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome D

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207RNA polymerase II subunit A C-terminal domain phosphatase SSU72PRO_0000255610Add
BLAST

Interactioni

Subunit structurei

Component of the cleavage and polyadenylation factor (CPF) complex.By similarity

Protein-protein interaction databases

STRINGi28985.Q6CQ61.

Structurei

3D structure databases

ProteinModelPortaliQ6CQ61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SSU72 phosphatase family.Curated

Phylogenomic databases

eggNOGiCOG5211.
HOGENOMiHOG000183445.
InParanoidiQ6CQ61.
KOiK15544.
OMAiWQERWPN.
OrthoDBiEOG7GTTG0.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CQ61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESMRNSGL KFCTVCASNN NRSMESHRVL EEAGYDVSSY GTGSAVRLPG
60 70 80 90 100
LSIDKPNVYS FGTPYDDIYN DLISQSEDRY KQNGVLEMLD RNRKLKKAPE
110 120 130 140 150
KWHDGRKVFD FVFTCEERCF DSVCEDLMNR GGQLNLIAHI INIDIKDDNE
160 170 180 190 200
NAKIGGRAIL RLADMLRDKV FECEKNGTQF EDFIMDVFTE WQEKYPKLPL

TYSAAYY
Length:207
Mass (Da):23,838
Last modified:August 16, 2004 - v1
Checksum:i8E050E3873B90B6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382124 Genomic DNA. Translation: CAH01024.1.
RefSeqiXP_453928.1. XM_453928.1.

Genome annotation databases

GeneIDi2893209.
KEGGikla:KLLA0D19514g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382124 Genomic DNA. Translation: CAH01024.1 .
RefSeqi XP_453928.1. XM_453928.1.

3D structure databases

ProteinModelPortali Q6CQ61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CQ61.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2893209.
KEGGi kla:KLLA0D19514g.

Phylogenomic databases

eggNOGi COG5211.
HOGENOMi HOG000183445.
InParanoidi Q6CQ61.
KOi K15544.
OMAi WQERWPN.
OrthoDBi EOG7GTTG0.

Family and domain databases

InterProi IPR006811. RNA_pol_II_suA.
[Graphical view ]
PANTHERi PTHR20383. PTHR20383. 1 hit.
Pfami PF04722. Ssu72. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSSU72_KLULA
AccessioniPrimary (citable) accession number: Q6CQ61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3