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Q6CQ61 (SSU72_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

Short name=CTD phosphatase SSU72
EC=3.1.3.16
Alternative name(s):
Suppressor of SUA7 protein 2 homolog
Gene names
Name:SSU72
Ordered Locus Names:KLLA0D19514g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1) By similarity.

Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Component of the cleavage and polyadenylation factor (CPF) complex By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SSU72 phosphatase family.

Ontologies

Keywords
   Biological processmRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207RNA polymerase II subunit A C-terminal domain phosphatase SSU72
PRO_0000255610

Sequences

Sequence LengthMass (Da)Tools
Q6CQ61 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 8E050E3873B90B6E

FASTA20723,838
        10         20         30         40         50         60 
MSESMRNSGL KFCTVCASNN NRSMESHRVL EEAGYDVSSY GTGSAVRLPG LSIDKPNVYS 

        70         80         90        100        110        120 
FGTPYDDIYN DLISQSEDRY KQNGVLEMLD RNRKLKKAPE KWHDGRKVFD FVFTCEERCF 

       130        140        150        160        170        180 
DSVCEDLMNR GGQLNLIAHI INIDIKDDNE NAKIGGRAIL RLADMLRDKV FECEKNGTQF 

       190        200 
EDFIMDVFTE WQEKYPKLPL TYSAAYY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382124 Genomic DNA. Translation: CAH01024.1.
RefSeqXP_453928.1. XM_453928.1.

3D structure databases

ProteinModelPortalQ6CQ61.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CQ61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893209.
KEGGkla:KLLA0D19514g.

Phylogenomic databases

eggNOGCOG5211.
HOGENOMHOG000183445.
KOK15544.
OMAWQERWPN.
OrthoDBEOG7GTTG0.

Family and domain databases

InterProIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERPTHR20383. PTHR20383. 1 hit.
PfamPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSU72_KLULA
AccessionPrimary (citable) accession number: Q6CQ61
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families