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Protein

cAMP-dependent protein kinase regulatory subunit

Gene

PKAR

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei297cAMP 1By similarity1
Binding sitei306cAMP 1By similarity1
Binding sitei416cAMP 2By similarity1
Binding sitei425cAMP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 347cAMP 1Add BLAST116
Nucleotide bindingi350 – 466cAMP 2Add BLAST117

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandcAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase regulatory subunit
Short name:
PKA regulatory subunit
Gene namesi
Name:PKAR
Ordered Locus Names:KLLA0E04070g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054101 – 466cAMP-dependent protein kinase regulatory subunitAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi284590.XP_454132.1

Structurei

3D structure databases

ProteinModelPortaliQ6CPK7
SMRiQ6CPK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 231Dimerization and phosphorylationSequence analysisAdd BLAST207

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1113 Eukaryota
COG0664 LUCA
HOGENOMiHOG000196669
InParanoidiQ6CPK7
KOiK04739
OMAiTFFFVEE
OrthoDBiEOG092C3TMX

Family and domain databases

CDDicd00038 CAP_ED, 2 hits
Gene3Di2.60.120.10, 2 hits
InterProiView protein in InterPro
IPR012198 cAMP_dep_PK_reg_su
IPR003117 cAMP_dep_PK_reg_su_I/II_a/b
IPR018490 cNMP-bd-like
IPR018488 cNMP-bd_CS
IPR000595 cNMP-bd_dom
IPR014710 RmlC-like_jellyroll
PfamiView protein in Pfam
PF00027 cNMP_binding, 2 hits
PF02197 RIIa, 1 hit
PIRSFiPIRSF000548 PK_regulatory, 1 hit
SMARTiView protein in SMART
SM00100 cNMP, 2 hits
SM00394 RIIa, 1 hit
SUPFAMiSSF51206 SSF51206, 2 hits
PROSITEiView protein in PROSITE
PS00888 CNMP_BINDING_1, 2 hits
PS00889 CNMP_BINDING_2, 2 hits
PS50042 CNMP_BINDING_3, 2 hits

Sequencei

Sequence statusi: Complete.

Q6CPK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYQTELDL FKNEVEQKQP NDFLQFAANY FTKRLEQQRT FVRNQESLAL
60 70 80 90 100
SKGIVLFPST SKHDSVAASS ASLSHGSSKA NASQSGISSS GVDEDVLFKS
110 120 130 140 150
PFVDRGPHST HIVDHLDSTH SNTTASPAKA SGGDAPGIFK GNFNVGTESQ
160 170 180 190 200
RKVNSSVDPM APEPTATTHS FPRRSVVNPK PLPINFNAQR RTSVSGETLQ
210 220 230 240 250
PDHLDDWKPE NFQEKSPEQV SRLEKAVGKN FLFNKLDSDS KKLVINSLEE
260 270 280 290 300
KSIPQGKEII KQGDEGDYFY IVEDGTVEFY VNNQKVNTSG PGSSFGELAL
310 320 330 340 350
MYNSPRAATV IASTDCILWA LDRLTFRRIL LGGSFKKRIL YDDLLKNIPI
360 370 380 390 400
LKSLSTYDRA KLADALDTEY YEAGQTIIKE GDTGENFYFI EYGEADVSQE
410 420 430 440 450
GKGVITKLGK GDYFGEVALL NDLPRQATVT ATARTKVATL GKSGFQRLLG
460
PVVDVLKLND PTRSKH
Length:466
Mass (Da):51,276
Last modified:August 16, 2004 - v1
Checksum:i60BE1A826165C6BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA Translation: CAG99219.1
RefSeqiXP_454132.1, XM_454132.1

Genome annotation databases

EnsemblFungiiCAG99219; CAG99219; KLLA0_E04181g
GeneIDi2893813
KEGGikla:KLLA0E04181g

Similar proteinsi

Entry informationi

Entry nameiKAPR_KLULA
AccessioniPrimary (citable) accession number: Q6CPK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health