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Protein

cAMP-dependent protein kinase regulatory subunit

Gene

PKAR

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei297cAMP 1By similarity1
Binding sitei306cAMP 1By similarity1
Binding sitei416cAMP 2By similarity1
Binding sitei425cAMP 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi232 – 347cAMP 1Add BLAST116
Nucleotide bindingi350 – 466cAMP 2Add BLAST117

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase regulatory subunit
Short name:
PKA regulatory subunit
Gene namesi
Name:PKAR
Ordered Locus Names:KLLA0E04070g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002054101 – 466cAMP-dependent protein kinase regulatory subunitAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).By similarity

Protein-protein interaction databases

STRINGi284590.XP_454132.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CPK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 231Dimerization and phosphorylationSequence analysisAdd BLAST207

Sequence similaritiesi

Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
HOGENOMiHOG000196669.
InParanoidiQ6CPK7.
KOiK04739.
OMAiCANYFNS.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CPK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYQTELDL FKNEVEQKQP NDFLQFAANY FTKRLEQQRT FVRNQESLAL
60 70 80 90 100
SKGIVLFPST SKHDSVAASS ASLSHGSSKA NASQSGISSS GVDEDVLFKS
110 120 130 140 150
PFVDRGPHST HIVDHLDSTH SNTTASPAKA SGGDAPGIFK GNFNVGTESQ
160 170 180 190 200
RKVNSSVDPM APEPTATTHS FPRRSVVNPK PLPINFNAQR RTSVSGETLQ
210 220 230 240 250
PDHLDDWKPE NFQEKSPEQV SRLEKAVGKN FLFNKLDSDS KKLVINSLEE
260 270 280 290 300
KSIPQGKEII KQGDEGDYFY IVEDGTVEFY VNNQKVNTSG PGSSFGELAL
310 320 330 340 350
MYNSPRAATV IASTDCILWA LDRLTFRRIL LGGSFKKRIL YDDLLKNIPI
360 370 380 390 400
LKSLSTYDRA KLADALDTEY YEAGQTIIKE GDTGENFYFI EYGEADVSQE
410 420 430 440 450
GKGVITKLGK GDYFGEVALL NDLPRQATVT ATARTKVATL GKSGFQRLLG
460
PVVDVLKLND PTRSKH
Length:466
Mass (Da):51,276
Last modified:August 16, 2004 - v1
Checksum:i60BE1A826165C6BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99219.1.
RefSeqiXP_454132.1. XM_454132.1.

Genome annotation databases

EnsemblFungiiCAG99219; CAG99219; KLLA0_E04181g.
GeneIDi2893813.
KEGGikla:KLLA0E04181g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99219.1.
RefSeqiXP_454132.1. XM_454132.1.

3D structure databases

ProteinModelPortaliQ6CPK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_454132.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG99219; CAG99219; KLLA0_E04181g.
GeneIDi2893813.
KEGGikla:KLLA0E04181g.

Phylogenomic databases

eggNOGiKOG1113. Eukaryota.
COG0664. LUCA.
HOGENOMiHOG000196669.
InParanoidiQ6CPK7.
KOiK04739.
OMAiCANYFNS.
OrthoDBiEOG092C3TMX.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
InterProiIPR012198. cAMP_dep_PK_reg_su.
IPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF000548. PK_regulatory. 1 hit.
SMARTiSM00100. cNMP. 2 hits.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 2 hits.
PROSITEiPS00888. CNMP_BINDING_1. 2 hits.
PS00889. CNMP_BINDING_2. 2 hits.
PS50042. CNMP_BINDING_3. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAPR_KLULA
AccessioniPrimary (citable) accession number: Q6CPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.