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Q6CNT6 (PP4C_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit

Short name=PP4C
EC=3.1.3.16
Gene names
Name:PPH3
Ordered Locus Names:KLLA0E10032g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subunit structure

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMMethylation
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Serine/threonine-protein phosphatase 4 catalytic subunit
PRO_0000223651

Sites

Active site1121Proton donor By similarity
Metal binding511Manganese 1 By similarity
Metal binding531Manganese 1 By similarity
Metal binding791Manganese 1 By similarity
Metal binding791Manganese 2 By similarity
Metal binding1111Manganese 2 By similarity
Metal binding1611Manganese 2 By similarity
Metal binding2351Manganese 2 By similarity

Amino acid modifications

Modified residue3081Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CNT6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5BF6D3BFDAB84CD8

FASTA30835,167
        10         20         30         40         50         60 
MMKLDEIIET LRQGKHVDED SIYSLCVMAQ ELLMNESNVT HVDTPVTICG DIHGQLHDLL 

        70         80         90        100        110        120 
TLFAKSGGIE KNRYIFLGDF VDRGFYSLES FLLLVCYKLR YPDRIVLIRG NHETRQITKV 

       130        140        150        160        170        180 
YGFYDEVVRK YGNSNVWRYC CEVFDYLPLG AIVNNKVFCV HGGLSPDVLS INEIRTIDRK 

       190        200        210        220        230        240 
KEVPHEGAMC DLLWSDPEDV DTWSLSPRGA GFLFGQNEVD KFLHTNSVEL IARAHQLVME 

       250        260        270        280        290        300 
GYKEMFDGGL VTVWSAPNYC YRCGNVAAVL RIDDDMTKDY TIFEAVQARD SGGNVILPTK 


KPQMDYFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382125 Genomic DNA. Translation: CAG99490.1.
RefSeqXP_454403.1. XM_454403.1.

3D structure databases

ProteinModelPortalQ6CNT6.
SMRQ6CNT6. Positions 1-307.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CNT6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893827.
KEGGkla:KLLA0E10055g.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172696.
KOK15423.
OMAYIARAHQ.
OrthoDBEOG7FFN29.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP4C_KLULA
AccessionPrimary (citable) accession number: Q6CNT6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families