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Q6CNT6

- PP4C_KLULA

UniProt

Q6CNT6 - PP4C_KLULA

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene
PPH3, KLLA0E10032g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Manganese 1 By similarity
Metal bindingi53 – 531Manganese 1 By similarity
Metal bindingi79 – 791Manganese 1 By similarity
Metal bindingi79 – 791Manganese 2 By similarity
Metal bindingi111 – 1111Manganese 2 By similarity
Active sitei112 – 1121Proton donor By similarity
Metal bindingi161 – 1611Manganese 2 By similarity
Metal bindingi235 – 2351Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:KLLA0E10032g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000223651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei308 – 3081Leucine methyl ester By similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4 By similarity.

Protein-protein interaction databases

STRINGi28985.Q6CNT6.

Structurei

3D structure databases

ProteinModelPortaliQ6CNT6.
SMRiQ6CNT6. Positions 1-307.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
KOiK15423.
OMAiYIARAHQ.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CNT6-1 [UniParc]FASTAAdd to Basket

« Hide

MMKLDEIIET LRQGKHVDED SIYSLCVMAQ ELLMNESNVT HVDTPVTICG    50
DIHGQLHDLL TLFAKSGGIE KNRYIFLGDF VDRGFYSLES FLLLVCYKLR 100
YPDRIVLIRG NHETRQITKV YGFYDEVVRK YGNSNVWRYC CEVFDYLPLG 150
AIVNNKVFCV HGGLSPDVLS INEIRTIDRK KEVPHEGAMC DLLWSDPEDV 200
DTWSLSPRGA GFLFGQNEVD KFLHTNSVEL IARAHQLVME GYKEMFDGGL 250
VTVWSAPNYC YRCGNVAAVL RIDDDMTKDY TIFEAVQARD SGGNVILPTK 300
KPQMDYFL 308
Length:308
Mass (Da):35,167
Last modified:August 16, 2004 - v1
Checksum:i5BF6D3BFDAB84CD8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99490.1.
RefSeqiXP_454403.1. XM_454403.1.

Genome annotation databases

GeneIDi2893827.
KEGGikla:KLLA0E10055g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99490.1 .
RefSeqi XP_454403.1. XM_454403.1.

3D structure databases

ProteinModelPortali Q6CNT6.
SMRi Q6CNT6. Positions 1-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CNT6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2893827.
KEGGi kla:KLLA0E10055g.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
KOi K15423.
OMAi YIARAHQ.
OrthoDBi EOG7FFN29.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPP4C_KLULA
AccessioniPrimary (citable) accession number: Q6CNT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi