Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6CNR2

- ACH1_KLULA

UniProt

Q6CNR2 - ACH1_KLULA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 30215-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei392 – 3921Coenzyme ABy similarity
Binding sitei396 – 3961Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:KLLA0E10549g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CNR2.

Structurei

3D structure databases

ProteinModelPortaliQ6CNR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 2815Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
InParanoidiQ6CNR2.
KOiK01067.
OMAiDYQPILT.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CNR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV
60 70 80 90 100
PEALIKHVEE NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK
110 120 130 140 150
PIAKAINDGR IQFFDKHLSM FPQDLTYGYY SRNRTDGKIL DYTIIEATAI
160 170 180 190 200
KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN TATPSFEGLH DIDMPVNPPF
210 220 230 240 250
RQPYPYTAVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN TPSDATSQSI
260 270 280 290 300
ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW
310 320 330 340 350
TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS
360 370 380 390 400
QVVSNNPELI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF
410 420 430 440 450
LRNAKLSIMH APAARPTKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL
460 470 480 490 500
ADLRGLSPRE RAREIIKNCA HPDYQPILTD YLDRSEHYAK LHKCMHEPHM
510 520
LKNAFKFHLN LSEKGTMKVD NWD
Length:523
Mass (Da):58,265
Last modified:August 16, 2004 - v1
Checksum:iA4F2099D19383613
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99514.1.
RefSeqiXP_454427.1. XM_454427.1.

Genome annotation databases

GeneIDi2894510.
KEGGikla:KLLA0E10561g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99514.1 .
RefSeqi XP_454427.1. XM_454427.1.

3D structure databases

ProteinModelPortali Q6CNR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CNR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2894510.
KEGGi kla:KLLA0E10561g.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
InParanoidi Q6CNR2.
KOi K01067.
OMAi DYQPILT.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiACH1_KLULA
AccessioniPrimary (citable) accession number: Q6CNR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3