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Q6CNR2

- ACH1_KLULA

UniProt

Q6CNR2 - ACH1_KLULA

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Protein

Acetyl-CoA hydrolase

Gene
ACH1, KLLA0E10549g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:KLLA0E10549g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215520Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CNR2.

Structurei

3D structure databases

ProteinModelPortaliQ6CNR2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0427.
HOGENOMiHOG000172597.
KOiK01067.
OMAiDYQPILT.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CNR2-1 [UniParc]FASTAAdd to Basket

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MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV    50
PEALIKHVEE NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK 100
PIAKAINDGR IQFFDKHLSM FPQDLTYGYY SRNRTDGKIL DYTIIEATAI 150
KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN TATPSFEGLH DIDMPVNPPF 200
RQPYPYTAVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN TPSDATSQSI 250
ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW 300
TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS 350
QVVSNNPELI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF 400
LRNAKLSIMH APAARPTKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL 450
ADLRGLSPRE RAREIIKNCA HPDYQPILTD YLDRSEHYAK LHKCMHEPHM 500
LKNAFKFHLN LSEKGTMKVD NWD 523
Length:523
Mass (Da):58,265
Last modified:August 16, 2004 - v1
Checksum:iA4F2099D19383613
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99514.1.
RefSeqiXP_454427.1. XM_454427.1.

Genome annotation databases

GeneIDi2894510.
KEGGikla:KLLA0E10561g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99514.1 .
RefSeqi XP_454427.1. XM_454427.1.

3D structure databases

ProteinModelPortali Q6CNR2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CNR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2894510.
KEGGi kla:KLLA0E10561g.

Phylogenomic databases

eggNOGi COG0427.
HOGENOMi HOG000172597.
KOi K01067.
OMAi DYQPILT.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiACH1_KLULA
AccessioniPrimary (citable) accession number: Q6CNR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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