Q6CNR2 (ACH1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-CoA hydrolase
EC=3.1.2.1

Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	KLLA0E10549g

Organism

Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

284590 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › Kluyveromyces lactis

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Acetyl-CoA hydrolase		PRO_0000215520

Sequences

	Sequence		Length	Mass (Da)
	Q6CNR2 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A4F2099D19383613	FASTA	523	58,265
	10 20 30 40 50 60 MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV PEALIKHVEE 70 80 90 100 110 120 NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK PIAKAINDGR IQFFDKHLSM 130 140 150 160 170 180 FPQDLTYGYY SRNRTDGKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN 190 200 210 220 230 240 TATPSFEGLH DIDMPVNPPF RQPYPYTAVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN 250 260 270 280 290 300 TPSDATSQSI ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW 310 320 330 340 350 360 TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS QVVSNNPELI 370 380 390 400 410 420 RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF LRNAKLSIMH APAARPTKTD 430 440 450 460 470 480 PTGISTIVPM ASHVDQTEHD LDVLVTDQGL ADLRGLSPRE RAREIIKNCA HPDYQPILTD 490 500 510 520 YLDRSEHYAK LHKCMHEPHM LKNAFKFHLN LSEKGTMKVD NWD

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382125 Genomic DNA. Translation: CAG99514.1.
RefSeq	XP_454427.1. XM_454427.1.
3D structure databases
ProteinModelPortal	Q6CNR2.
ModBase	Search...
Protein-protein interaction databases
STRING	28985.Q6CNR2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2894510.
KEGG	kla:KLLA0E10561g.
Phylogenomic databases
eggNOG	COG0427.
HOGENOM	HOG000172597.
KO	K01067.
OMA	EVSNHPE.
OrthoDB	EOG4DBXNW.
Family and domain databases
InterPro	IPR026888. AcetylCoA_hyd_C. IPR003702. ActCoA_hydro. IPR017821. Succinate_CoA_transferase. [Graphical view]
PANTHER	PTHR21432. PTHR21432. 1 hit. PTHR21432:SF10. PTHR21432:SF10. 1 hit.
Pfam	PF13336. AcetylCoA_hyd_C. 1 hit. PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_KLULA

Accession

Primary (citable) accession number: Q6CNR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program