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Q6CNR2

- ACH1_KLULA

UniProt

Q6CNR2 - ACH1_KLULA

Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

    Catalytic activityi

    Acetyl-CoA + H2O = CoA + acetate.

    GO - Molecular functioni

    1. acetyl-CoA hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. acetyl-CoA metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-CoA hydrolase (EC:3.1.2.1)
    Alternative name(s):
    Acetyl-CoA deacylase
    Short name:
    Acetyl-CoA acylase
    Gene namesi
    Name:ACH1
    Ordered Locus Names:KLLA0E10549g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome E

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Acetyl-CoA hydrolasePRO_0000215520Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CNR2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CNR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0427.
    HOGENOMiHOG000172597.
    KOiK01067.
    OMAiDYQPILT.
    OrthoDBiEOG7TQV8M.

    Family and domain databases

    InterProiIPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view]
    PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CNR2-1 [UniParc]FASTAAdd to Basket

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    MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV    50
    PEALIKHVEE NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK 100
    PIAKAINDGR IQFFDKHLSM FPQDLTYGYY SRNRTDGKIL DYTIIEATAI 150
    KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN TATPSFEGLH DIDMPVNPPF 200
    RQPYPYTAVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN TPSDATSQSI 250
    ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW 300
    TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS 350
    QVVSNNPELI RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF 400
    LRNAKLSIMH APAARPTKTD PTGISTIVPM ASHVDQTEHD LDVLVTDQGL 450
    ADLRGLSPRE RAREIIKNCA HPDYQPILTD YLDRSEHYAK LHKCMHEPHM 500
    LKNAFKFHLN LSEKGTMKVD NWD 523
    Length:523
    Mass (Da):58,265
    Last modified:August 16, 2004 - v1
    Checksum:iA4F2099D19383613
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382125 Genomic DNA. Translation: CAG99514.1.
    RefSeqiXP_454427.1. XM_454427.1.

    Genome annotation databases

    GeneIDi2894510.
    KEGGikla:KLLA0E10561g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382125 Genomic DNA. Translation: CAG99514.1 .
    RefSeqi XP_454427.1. XM_454427.1.

    3D structure databases

    ProteinModelPortali Q6CNR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CNR2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2894510.
    KEGGi kla:KLLA0E10561g.

    Phylogenomic databases

    eggNOGi COG0427.
    HOGENOMi HOG000172597.
    KOi K01067.
    OMAi DYQPILT.
    OrthoDBi EOG7TQV8M.

    Family and domain databases

    InterProi IPR026888. AcetylCoA_hyd_C.
    IPR003702. ActCoA_hydro.
    [Graphical view ]
    Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
    PF02550. AcetylCoA_hydro. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiACH1_KLULA
    AccessioniPrimary (citable) accession number: Q6CNR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3