Reviewed, UniProtKB/Swiss-Prot Q6CNR2 (ACH1_KLULA)

Names and origin

Protein names

Recommended name:
    Acetyl-CoA hydrolase
    EC=3.1.2.1
Alternative name(s):
    Acetyl-CoA deacylase
      Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	KLLA0E10549g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Acetyl-CoA hydrolase		PRO_0000215520

Sequences

	Sequence		Length	Mass (Da)
	Q6CNR2-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A4F2099D19383613	FASTA	523	58,265
	10 20 30 40 50 60 MTVSRLLKDR VRYAPYLKKV KPVEELIPLF KDGQYIGWSG FTGVGAPKAV PEALIKHVEE 70 80 90 100 110 120 NNLQGKLRFN LFVGASAGPE ECKWAEHDMI LRRAPHQVGK PIAKAINDGR IQFFDKHLSM 130 140 150 160 170 180 FPQDLTYGYY SRNRTDGKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIS VSDKIIIEVN 190 200 210 220 230 240 TATPSFEGLH DIDMPVNPPF RQPYPYTAVD QKNGLDSIPV DPERVVAVVE STQRDVVGPN 250 260 270 280 290 300 TPSDATSQSI ARHLVEFFEN EVRHGRLPEN LHPLQSGIGN IANAVIEGLT DSSFKNLTVW 310 320 330 340 350 360 TEVLQDSFLD LFENGALDYA TATSIRLTEA GFQKFFDNWD DFSKKLCLRS QVVSNNPELI 370 380 390 400 410 420 RRLGVIAMNT PVEVDIYAHA NSTNVSGSRM LNGLGGSADF LRNAKLSIMH APAARPTKTD 430 440 450 460 470 480 PTGISTIVPM ASHVDQTEHD LDVLVTDQGL ADLRGLSPRE RAREIIKNCA HPDYQPILTD 490 500 510 520 YLDRSEHYAK LHKCMHEPHM LKNAFKFHLN LSEKGTMKVD NWD

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382125 Genomic DNA. Translation: CAG99514.1.
RefSeq	XP_454427.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CNR2.
Genome annotation databases
GeneID	2894510.
GenomeReviews	Gene locus KLLA0E10549g in contig CR382125_GR.
KEGG	kla:KLLA0E10549g.
Phylogenomic databases
HOGENOM	Q6CNR2.
OMA	DEALSWH.
Enzyme and pathway databases
BRENDA	3.1.2.1. 74088.
Family and domain databases
InterPro	IPR003702. ActCoA_hydro. [Graphical view]
PANTHER	PTHR21432. ActCoA_hydro. 1 hit.
Pfam	PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_KLULA

Accession

Primary (citable) accession number: Q6CNR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)