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Q6CN95 (HAT1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit
EC=2.3.1.48
Gene names
Name:HAT1
Ordered Locus Names:KLLA0E14344g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces ›

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

histone acetyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Histone acetyltransferase type B catalytic subunit
PRO_0000227725

Regions

Domain138 – 290153N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
Q6CN95 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 72EED909A3E6390D

FASTA39045,913
        10         20         30         40         50         60 
MAVDLRPETW TVSSNEALNL SLVDENGAVN FKPTFTYPIY GDSEQIFGYK NLQIFLAFDS 

        70         80         90        100        110        120 
ITFKPFVNVK YDAKLNNEIE DVQKLLLDKL PEDDVIIKDE EAWIKTFTKE QETFALPEKD 

       130        140        150        160        170        180 
KLVEEYEIGD QEFVIYRVSL QDPAIKMLHK RMQIFTLLFI ESASYIDEND SSWEIFIVFN 

       190        200        210        220        230        240 
KNSKKCIGYT TTYQFWKYLG AQSFDSSKAD EQKCRAKISQ FLIMPPYQGH GHGKRLYQAI 

       250        260        270        280        290        300 
VKQWMNDLSV VEITVEDPNE SFDDLRDRCD FERVINKNSL ADCPNELPIN IDWITKKQAQ 

       310        320        330        340        350        360 
LKLEKRQFMR ILEMFLLYQK SPNYRLQLKK RIYEKNFEAL MDMDESLKKD KLQTAFQSLT 

       370        380        390 
EDYNRILSKV AIRKRTFSDS QGESDKRLKA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382125 Genomic DNA. Translation: CAG99681.1.
RefSeqXP_454594.1. XM_454594.1.

3D structure databases

ProteinModelPortalQ6CN95.
SMRQ6CN95. Positions 5-321.
ModBaseSearch...

Protein-protein interaction databases

STRING28985.Q6CN95.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2893933.
KEGGkla:KLLA0E14301g.

Phylogenomic databases

eggNOGNOG326277.
HOGENOMHOG000074728.
KOK11303.
OMATAGPLHI.
OrthoDBEOG4G7G7K.

Family and domain databases

Gene3D1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAT1_KLULA
AccessionPrimary (citable) accession number: Q6CN95
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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