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Q6CN95

- HAT1_KLULA

UniProt

Q6CN95 - HAT1_KLULA

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Protein

Histone acetyltransferase type B catalytic subunit

Gene
HAT1, KLLA0E14344g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
Gene namesi
Name:HAT1
Ordered Locus Names:KLLA0E14344g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Histone acetyltransferase type B catalytic subunitPRO_0000227725Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Protein-protein interaction databases

STRINGi28985.Q6CN95.

Structurei

3D structure databases

ProteinModelPortaliQ6CN95.
SMRiQ6CN95. Positions 5-321.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 290153N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Belongs to the HAT1 family.

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000074728.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CN95-1 [UniParc]FASTAAdd to Basket

« Hide

MAVDLRPETW TVSSNEALNL SLVDENGAVN FKPTFTYPIY GDSEQIFGYK    50
NLQIFLAFDS ITFKPFVNVK YDAKLNNEIE DVQKLLLDKL PEDDVIIKDE 100
EAWIKTFTKE QETFALPEKD KLVEEYEIGD QEFVIYRVSL QDPAIKMLHK 150
RMQIFTLLFI ESASYIDEND SSWEIFIVFN KNSKKCIGYT TTYQFWKYLG 200
AQSFDSSKAD EQKCRAKISQ FLIMPPYQGH GHGKRLYQAI VKQWMNDLSV 250
VEITVEDPNE SFDDLRDRCD FERVINKNSL ADCPNELPIN IDWITKKQAQ 300
LKLEKRQFMR ILEMFLLYQK SPNYRLQLKK RIYEKNFEAL MDMDESLKKD 350
KLQTAFQSLT EDYNRILSKV AIRKRTFSDS QGESDKRLKA 390
Length:390
Mass (Da):45,913
Last modified:August 16, 2004 - v1
Checksum:i72EED909A3E6390D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99681.1.
RefSeqiXP_454594.1. XM_454594.1.

Genome annotation databases

GeneIDi2893933.
KEGGikla:KLLA0E14301g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382125 Genomic DNA. Translation: CAG99681.1 .
RefSeqi XP_454594.1. XM_454594.1.

3D structure databases

ProteinModelPortali Q6CN95.
SMRi Q6CN95. Positions 5-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CN95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2893933.
KEGGi kla:KLLA0E14301g.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000074728.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHAT1_KLULA
AccessioniPrimary (citable) accession number: Q6CN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3