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Q6CN95

- HAT1_KLULA

UniProt

Q6CN95 - HAT1_KLULA

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei173 – 1731Interaction with histone H4 N-terminusBy similarity
Active sitei256 – 2561Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
Ordered Locus Names:KLLA0E14344g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome E

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Histone acetyltransferase type B catalytic subunitPRO_0000227725Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.By similarity

Protein-protein interaction databases

STRINGi28985.Q6CN95.

Structurei

3D structure databases

ProteinModelPortaliQ6CN95.
SMRiQ6CN95. Positions 5-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 290153N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni42 – 443Interaction with histone H4 N-terminusBy similarity
Regioni193 – 1953Interaction with histone H4 N-terminusBy similarity
Regioni221 – 2233Acetyl-CoA bindingBy similarity
Regioni228 – 2347Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000074728.
InParanoidiQ6CN95.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CN95-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVDLRPETW TVSSNEALNL SLVDENGAVN FKPTFTYPIY GDSEQIFGYK
60 70 80 90 100
NLQIFLAFDS ITFKPFVNVK YDAKLNNEIE DVQKLLLDKL PEDDVIIKDE
110 120 130 140 150
EAWIKTFTKE QETFALPEKD KLVEEYEIGD QEFVIYRVSL QDPAIKMLHK
160 170 180 190 200
RMQIFTLLFI ESASYIDEND SSWEIFIVFN KNSKKCIGYT TTYQFWKYLG
210 220 230 240 250
AQSFDSSKAD EQKCRAKISQ FLIMPPYQGH GHGKRLYQAI VKQWMNDLSV
260 270 280 290 300
VEITVEDPNE SFDDLRDRCD FERVINKNSL ADCPNELPIN IDWITKKQAQ
310 320 330 340 350
LKLEKRQFMR ILEMFLLYQK SPNYRLQLKK RIYEKNFEAL MDMDESLKKD
360 370 380 390
KLQTAFQSLT EDYNRILSKV AIRKRTFSDS QGESDKRLKA
Length:390
Mass (Da):45,913
Last modified:August 16, 2004 - v1
Checksum:i72EED909A3E6390D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99681.1.
RefSeqiXP_454594.1. XM_454594.1.

Genome annotation databases

GeneIDi2893933.
KEGGikla:KLLA0E14301g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99681.1 .
RefSeqi XP_454594.1. XM_454594.1.

3D structure databases

ProteinModelPortali Q6CN95.
SMRi Q6CN95. Positions 5-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CN95.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2893933.
KEGGi kla:KLLA0E14301g.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000074728.
InParanoidi Q6CN95.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHAT1_KLULA
AccessioniPrimary (citable) accession number: Q6CN95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3