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Q6CN95

- HAT1_KLULA

UniProt

Q6CN95 - HAT1_KLULA

Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin silencing at telomere Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Gene namesi
    Name:HAT1
    Ordered Locus Names:KLLA0E14344g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome E

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone acetyltransferase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Histone acetyltransferase type B catalytic subunitPRO_0000227725Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CN95.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CN95.
    SMRiQ6CN95. Positions 5-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini138 – 290153N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG326277.
    HOGENOMiHOG000074728.
    KOiK11303.
    OMAiHISYDEK.
    OrthoDBiEOG7HTHSD.

    Family and domain databases

    Gene3Di1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CN95-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVDLRPETW TVSSNEALNL SLVDENGAVN FKPTFTYPIY GDSEQIFGYK    50
    NLQIFLAFDS ITFKPFVNVK YDAKLNNEIE DVQKLLLDKL PEDDVIIKDE 100
    EAWIKTFTKE QETFALPEKD KLVEEYEIGD QEFVIYRVSL QDPAIKMLHK 150
    RMQIFTLLFI ESASYIDEND SSWEIFIVFN KNSKKCIGYT TTYQFWKYLG 200
    AQSFDSSKAD EQKCRAKISQ FLIMPPYQGH GHGKRLYQAI VKQWMNDLSV 250
    VEITVEDPNE SFDDLRDRCD FERVINKNSL ADCPNELPIN IDWITKKQAQ 300
    LKLEKRQFMR ILEMFLLYQK SPNYRLQLKK RIYEKNFEAL MDMDESLKKD 350
    KLQTAFQSLT EDYNRILSKV AIRKRTFSDS QGESDKRLKA 390
    Length:390
    Mass (Da):45,913
    Last modified:August 16, 2004 - v1
    Checksum:i72EED909A3E6390D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382125 Genomic DNA. Translation: CAG99681.1.
    RefSeqiXP_454594.1. XM_454594.1.

    Genome annotation databases

    GeneIDi2893933.
    KEGGikla:KLLA0E14301g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382125 Genomic DNA. Translation: CAG99681.1 .
    RefSeqi XP_454594.1. XM_454594.1.

    3D structure databases

    ProteinModelPortali Q6CN95.
    SMRi Q6CN95. Positions 5-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CN95.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2893933.
    KEGGi kla:KLLA0E14301g.

    Phylogenomic databases

    eggNOGi NOG326277.
    HOGENOMi HOG000074728.
    KOi K11303.
    OMAi HISYDEK.
    OrthoDBi EOG7HTHSD.

    Family and domain databases

    Gene3Di 1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiHAT1_KLULA
    AccessioniPrimary (citable) accession number: Q6CN95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3