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Protein

SVP1-like protein 2

Gene

HSV2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
SVP1-like protein 2
Gene namesi
Name:HSV2
Ordered Locus Names:KLLA0E15972g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510291 – 339SVP1-like protein 2Add BLAST339

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_454666.1.

Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 22Combined sources4
Beta strandi26 – 32Combined sources7
Beta strandi34 – 41Combined sources8
Turni42 – 45Combined sources4
Beta strandi46 – 52Combined sources7
Beta strandi56 – 61Combined sources6
Beta strandi65 – 72Combined sources8
Turni73 – 76Combined sources4
Beta strandi77 – 82Combined sources6
Turni83 – 86Combined sources4
Beta strandi87 – 93Combined sources7
Beta strandi98 – 103Combined sources6
Beta strandi105 – 112Combined sources8
Beta strandi115 – 122Combined sources8
Beta strandi127 – 133Combined sources7
Beta strandi138 – 141Combined sources4
Beta strandi144 – 148Combined sources5
Beta strandi150 – 152Combined sources3
Beta strandi155 – 160Combined sources6
Beta strandi163 – 165Combined sources3
Beta strandi173 – 176Combined sources4
Beta strandi182 – 187Combined sources6
Beta strandi189 – 200Combined sources12
Beta strandi202 – 208Combined sources7
Turni209 – 211Combined sources3
Beta strandi214 – 219Combined sources6
Beta strandi227 – 232Combined sources6
Beta strandi236 – 243Combined sources8
Turni244 – 246Combined sources3
Beta strandi247 – 252Combined sources6
Helixi256 – 260Combined sources5
Beta strandi279 – 283Combined sources5
Beta strandi294 – 307Combined sources14
Turni308 – 311Combined sources4
Beta strandi312 – 321Combined sources10
Turni322 – 325Combined sources4
Beta strandi326 – 336Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AV8X-ray3.35A1-339[»]
4AV9X-ray3.00A1-339[»]
4EXVX-ray3.00A1-339[»]
4V16X-ray2.80A1-256[»]
A275-339[»]
ProteinModelPortaliQ6CN23.
SMRiQ6CN23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati177 – 217WD 1Add BLAST41
Repeati222 – 261WD 2Add BLAST40

Domaini

May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
HOGENOMiHOG000217543.
InParanoidiQ6CN23.
OMAiCEMFRRY.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CN23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRNPIVPE NHVSNPIVDY EFNQDQSCLI VSTPKSFDIY NVHPLKRIMS
60 70 80 90 100
QEMPDAGTIR MLHRTNYIAF VSTKKELLHI WDDVKKQDIT RVKLDAAVKD
110 120 130 140 150
LFLSREFIVV SQGDVISIFK FGNPWNKITE DIKFGGVCEF ANGLLVYSNE
160 170 180 190 200
FNLGQIHVTR LQTDAEQVVG KGVLVKAHAN PVKMVRLNRK GDMVATCSQD
210 220 230 240 250
GTLIRVFQTD NGVLVREFRR GLDRTSIIDM RWSPDGSKLA VVSDKWTLHV
260 270 280 290 300
FEVFNDAENK RHVLKDWINI KYFQSEWSIC NFKLKVSKGS NDCKIAWISD
310 320 330
TGLVIVWPNR RLADTFKLNY NDDEHVWWLQ LNQRNEIPL
Length:339
Mass (Da):39,167
Last modified:August 16, 2004 - v1
Checksum:i01257B224618FB81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99753.1.
RefSeqiXP_454666.1. XM_454666.1.

Genome annotation databases

EnsemblFungiiCAG99753; CAG99753; KLLA0_E15885g.
GeneIDi2894192.
KEGGikla:KLLA0E15885g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99753.1.
RefSeqiXP_454666.1. XM_454666.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AV8X-ray3.35A1-339[»]
4AV9X-ray3.00A1-339[»]
4EXVX-ray3.00A1-339[»]
4V16X-ray2.80A1-256[»]
A275-339[»]
ProteinModelPortaliQ6CN23.
SMRiQ6CN23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_454666.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG99753; CAG99753; KLLA0_E15885g.
GeneIDi2894192.
KEGGikla:KLLA0E15885g.

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
HOGENOMiHOG000217543.
InParanoidiQ6CN23.
OMAiCEMFRRY.
OrthoDBiEOG092C3UKJ.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSV2_KLULA
AccessioniPrimary (citable) accession number: Q6CN23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.