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Protein

SVP1-like protein 2

Gene

HSV2

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
SVP1-like protein 2
Gene namesi
Name:HSV2
Ordered Locus Names:KLLA0E15972g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome E

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339SVP1-like protein 2PRO_0000051029Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_454666.1.

Structurei

Secondary structure

1
339
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 224Combined sources
Beta strandi26 – 327Combined sources
Beta strandi34 – 418Combined sources
Turni42 – 454Combined sources
Beta strandi46 – 527Combined sources
Beta strandi56 – 616Combined sources
Beta strandi65 – 728Combined sources
Turni73 – 764Combined sources
Beta strandi77 – 826Combined sources
Turni83 – 864Combined sources
Beta strandi87 – 937Combined sources
Beta strandi98 – 1036Combined sources
Beta strandi105 – 1128Combined sources
Beta strandi115 – 1228Combined sources
Beta strandi127 – 1337Combined sources
Beta strandi138 – 1414Combined sources
Beta strandi144 – 1485Combined sources
Beta strandi150 – 1523Combined sources
Beta strandi155 – 1606Combined sources
Beta strandi163 – 1653Combined sources
Beta strandi173 – 1764Combined sources
Beta strandi182 – 1876Combined sources
Beta strandi189 – 20012Combined sources
Beta strandi202 – 2087Combined sources
Turni209 – 2113Combined sources
Beta strandi214 – 2196Combined sources
Beta strandi227 – 2326Combined sources
Beta strandi236 – 2438Combined sources
Turni244 – 2463Combined sources
Beta strandi247 – 2526Combined sources
Helixi256 – 2605Combined sources
Beta strandi279 – 2835Combined sources
Beta strandi294 – 30714Combined sources
Turni308 – 3114Combined sources
Beta strandi312 – 32110Combined sources
Turni322 – 3254Combined sources
Beta strandi326 – 33611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AV8X-ray3.35A1-339[»]
4AV9X-ray3.00A1-339[»]
4EXVX-ray3.00A1-339[»]
4V16X-ray2.80A1-256[»]
A275-339[»]
ProteinModelPortaliQ6CN23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati177 – 21741WD 1Add
BLAST
Repeati222 – 26140WD 2Add
BLAST

Domaini

May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.By similarity

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated
Contains 2 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
HOGENOMiHOG000217543.
InParanoidiQ6CN23.
OMAiIRIFSTH.
OrthoDBiEOG7K3TWR.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CN23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTRNPIVPE NHVSNPIVDY EFNQDQSCLI VSTPKSFDIY NVHPLKRIMS
60 70 80 90 100
QEMPDAGTIR MLHRTNYIAF VSTKKELLHI WDDVKKQDIT RVKLDAAVKD
110 120 130 140 150
LFLSREFIVV SQGDVISIFK FGNPWNKITE DIKFGGVCEF ANGLLVYSNE
160 170 180 190 200
FNLGQIHVTR LQTDAEQVVG KGVLVKAHAN PVKMVRLNRK GDMVATCSQD
210 220 230 240 250
GTLIRVFQTD NGVLVREFRR GLDRTSIIDM RWSPDGSKLA VVSDKWTLHV
260 270 280 290 300
FEVFNDAENK RHVLKDWINI KYFQSEWSIC NFKLKVSKGS NDCKIAWISD
310 320 330
TGLVIVWPNR RLADTFKLNY NDDEHVWWLQ LNQRNEIPL
Length:339
Mass (Da):39,167
Last modified:August 16, 2004 - v1
Checksum:i01257B224618FB81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99753.1.
RefSeqiXP_454666.1. XM_454666.1.

Genome annotation databases

EnsemblFungiiCAG99753; CAG99753; KLLA0_E15885g.
GeneIDi2894192.
KEGGikla:KLLA0E15885g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382125 Genomic DNA. Translation: CAG99753.1.
RefSeqiXP_454666.1. XM_454666.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AV8X-ray3.35A1-339[»]
4AV9X-ray3.00A1-339[»]
4EXVX-ray3.00A1-339[»]
4V16X-ray2.80A1-256[»]
A275-339[»]
ProteinModelPortaliQ6CN23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_454666.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG99753; CAG99753; KLLA0_E15885g.
GeneIDi2894192.
KEGGikla:KLLA0E15885g.

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
ENOG410XQZ6. LUCA.
HOGENOMiHOG000217543.
InParanoidiQ6CN23.
OMAiIRIFSTH.
OrthoDBiEOG7K3TWR.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
SMARTiSM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSV2_KLULA
AccessioniPrimary (citable) accession number: Q6CN23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2004
Last modified: November 11, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.