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Q6CMK4 (NMT_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycylpeptide N-tetradecanoyltransferase
EC=2.3.1.97
Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name=NMT
Peptide N-myristoyltransferase
Gene names
Name:NMT1
Ordered Locus Names:KLLA0E19635g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity.

Catalytic activity

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the NMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processN-terminal protein myristoylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglycylpeptide N-tetradecanoyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Glycylpeptide N-tetradecanoyltransferase
PRO_0000064243

Regions

Region38 – 414Myristoyl CoA-binding By similarity
Region168 – 20437Myristoyl CoA-binding By similarity

Sites

Active site4471Proton acceptor; via carboxylate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CMK4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B74AE4DC9A528D41

FASTA44752,323
        10         20         30         40         50         60 
MSEEDKSKKL EELLKLLKVH DGDLSKFTSQ QRKDMNEYKF WKTQPVTKFD EVIKKEGPID 

        70         80         90        100        110        120 
SSKRPEDIPD TPLPLLGDFE WCTVDVNDEK QLEDVYVLLN ENYVEDKDST FRFNYSRDFL 

       130        140        150        160        170        180 
NWGLKPPGWK EEWQVGVRVK ETKRLVGFIS AIPTNLQVRG NDVRSVEINF LCVHKKLRSK 

       190        200        210        220        230        240 
RLAPILIKEV TRRVNKYDIW QALHTGGVVL PSPVSSCRYA HRPLNWSKLY DVEFTALPAN 

       250        260        270        280        290        300 
ATKTQMIAKY TLPKTPISNI KLMEERHVDE AFELFNKYQQ RFELRPNFDK EEFRHWILTR 

       310        320        330        340        350        360 
EDVVYSYIIE NDEGKVTDFV SFYSLPFTII NNPLYKDLGI GYMFYYASDA DFGYDRFSAE 

       370        380        390        400        410        420 
GTERLRKRLN LLINDACILA RNLKMDVFNA LTSQDNALFL EDLKFGPGDG FLNFYLFNYR 

       430        440 
CFPITGGIKE DQTFDVEKRS NVGVVLL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382125 Genomic DNA. Translation: CAG99922.1.
RefSeqXP_454835.1. XM_454835.1.

3D structure databases

ProteinModelPortalQ6CMK4.
SMRQ6CMK4. Positions 4-447.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CMK4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2894734.
GenomeReviewsGene locus KLLA0E19635g in contig CR382125_GR.
KEGGkla:KLLA0E19537g.

Phylogenomic databases

eggNOGfuNOG07746.
HOGENOMHBG314670.
OMASTCRYFH.
OrthoDBEOG4V9XZZ.

Family and domain databases

InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
Gene3DG3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
KOK00671.
PANTHERPTHR11377. Myristoyl_trans. 1 hit.
PfamPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMSSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITEPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNMT_KLULA
AccessionPrimary (citable) accession number: Q6CMK4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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