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Q6CMG6 (UBC6_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 6

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein UBC6
Ubiquitin-protein ligase UBC6
Gene names
Name:UBC6
Ordered Locus Names:KLLA0E20493g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length251 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Endoplasmic reticulum membrane By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 251251Ubiquitin-conjugating enzyme E2 6
PRO_0000082550

Regions

Topological domain1 – 229229Cytoplasmic Potential
Transmembrane230 – 25021Helical; Potential

Sites

Active site871Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CMG6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 621A26720595608B

FASTA25128,423
        10         20         30         40         50         60 
MASIQANKRL TKEYKNIVNN PPPFIIAAPH EDNILEWHYV ITGPPSTPYE NGQYHGTLTF 

        70         80         90        100        110        120 
PSDYPFNPPA IRMITPNGRF KENTRLCLSM SDYHPEAWNP AWSVVTILNG LLSFMTGDEQ 

       130        140        150        160        170        180 
TTGSVSTSDK DKRTLAKKSK HFNTYSNFKF KNMFPDLRES NIKDIEREAA LEAESKGAQQ 

       190        200        210        220        230        240 
EENKAQKLAT EKATSLDDIS DPEDRVRIQE LIKAEKDKKD QDKNPGENSN IKSLLCLILA 

       250 
IAIFFVGLIM K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382125 Genomic DNA. Translation: CAG99960.1.
RefSeqXP_454873.1. XM_454873.1.

3D structure databases

ProteinModelPortalQ6CMG6.
SMRQ6CMG6. Positions 6-159.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CMG6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2894674.
KEGGkla:KLLA0E20395g.

Phylogenomic databases

eggNOGCOG5078.
HOGENOMHOG000170329.
KOK04554.
OMAFMTGDES.
OrthoDBEOG70S7GF.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBC6_KLULA
AccessionPrimary (citable) accession number: Q6CMG6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways