UniProtKB - Q6CLS8 (ARGI_KLULA)
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Protein
Arginase
Gene
CAR1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Functioni
Catalytic activityi
L-arginine + H2O = L-ornithine + urea.1 Publication
Cofactori
Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation
: urea cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.1 PublicationProteins known to be involved in this subpathway in this organism are:
- Arginase (CAR1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 113 | Manganese 1By similarity | 1 | |
Metal bindingi | 136 | Manganese 1By similarity | 1 | |
Metal bindingi | 136 | Manganese 2By similarity | 1 | |
Metal bindingi | 138 | Manganese 2By similarity | 1 | |
Metal bindingi | 140 | Manganese 1By similarity | 1 | |
Binding sitei | 193 | SubstrateBy similarity | 1 | |
Metal bindingi | 242 | Manganese 1By similarity | 1 | |
Metal bindingi | 242 | Manganese 2By similarity | 1 | |
Metal bindingi | 244 | Manganese 2By similarity | 1 | |
Binding sitei | 256 | SubstrateBy similarity | 1 | |
Binding sitei | 287 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- arginase activity Source: UniProtKB-EC
- manganese ion binding Source: EnsemblFungi
- ornithine carbamoyltransferase inhibitor activity Source: EnsemblFungi
- zinc ion binding Source: EnsemblFungi
GO - Biological processi
- arginine catabolic process to ornithine Source: EnsemblFungi
- urea cycle Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Hydrolase |
Biological process | Arginine metabolism |
Ligand | Manganese, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00158; UER00270. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CAR11 Publication Ordered Locus Names:KLLA0F00704g |
Organismi | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
Taxonomic identifieri | 284590 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces › |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000432230 | 1 – 319 | ArginaseAdd BLAST | 319 |
Interactioni
Subunit structurei
Homotrimer.By similarity
Protein-protein interaction databases
STRINGi | 284590.XP_455111.1. |
Structurei
3D structure databases
ProteinModelPortali | Q6CLS8. |
SMRi | Q6CLS8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 138 – 142 | Substrate bindingBy similarity | 5 | |
Regioni | 149 – 151 | Substrate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the arginase family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG2965. Eukaryota. COG0010. LUCA. |
HOGENOMi | HOG000204319. |
InParanoidi | Q6CLS8. |
KOi | K01476. |
OMAi | SAVARHC. |
OrthoDBi | EOG092C3GMN. |
Family and domain databases
InterProi | View protein in InterPro IPR014033. Arginase. IPR006035. Ureohydrolase. IPR023696. Ureohydrolase_dom_sf. IPR020855. Ureohydrolase_Mn_BS. |
Pfami | View protein in Pfam PF00491. Arginase. 1 hit. |
PRINTSi | PR00116. ARGINASE. |
SUPFAMi | SSF52768. SSF52768. 1 hit. |
TIGRFAMsi | TIGR01229. rocF_arginase. 1 hit. |
PROSITEi | View protein in PROSITE PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6CLS8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDPRFDFF QQKKLGIVLA PFSGGQPKSG VENGPKYLMK QGLRSDIESL
60 70 80 90 100
GWETTLEEPL KGRDFESGKN DETDVYGIMK RPNLVGEATK LIYESVKKVS
110 120 130 140 150
NEGRLAVTLG GDHSIAIGTV AGVLDKYPNA GLLWIDAHAD INTCSTTESG
160 170 180 190 200
NIHGCPVSFL MGLDAKNTPP SLKWVPKCLD PKKIAYIGLR DVDAAERKIL
210 220 230 240 250
KDNGIASYSM YHVDRYGLNK VIEMALEKVA PNGDEPIMVS YDVDAIDPLY
260 270 280 290 300
VPATGTPVRG GLTLREGLFL VERIAETGRL VALDVVECNP ELASHDGHVV
310
DTITTGCSIA RCALGETLL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR382126 Genomic DNA. Translation: CAG97818.1. |
RefSeqi | XP_455111.1. XM_455111.1. |
Genome annotation databases
EnsemblFungii | CAG97818; CAG97818; KLLA0_F00704g. |
GeneIDi | 2895828. |
KEGGi | kla:KLLA0F00704g. |
Similar proteinsi
Entry informationi
Entry namei | ARGI_KLULA | |
Accessioni | Q6CLS8Primary (citable) accession number: Q6CLS8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 4, 2015 |
Last sequence update: | August 16, 2004 | |
Last modified: | March 28, 2018 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |