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Protein

Arginase

Gene

CAR1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.1 Publication

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.1 Publication
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (CAR1)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113Manganese 1By similarity1
Metal bindingi136Manganese 1By similarity1
Metal bindingi136Manganese 2By similarity1
Metal bindingi138Manganese 2By similarity1
Metal bindingi140Manganese 1By similarity1
Binding sitei193SubstrateBy similarity1
Metal bindingi242Manganese 1By similarity1
Metal bindingi242Manganese 2By similarity1
Metal bindingi244Manganese 2By similarity1
Binding sitei256SubstrateBy similarity1
Binding sitei287SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase1 Publication (EC:3.5.3.11 Publication)
Gene namesi
Name:CAR11 Publication
Ordered Locus Names:KLLA0F00704g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004322301 – 319ArginaseAdd BLAST319

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_455111.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CLS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 142Substrate bindingBy similarity5
Regioni149 – 151Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
HOGENOMiHOG000204319.
InParanoidiQ6CLS8.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG092C3GMN.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CLS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDPRFDFF QQKKLGIVLA PFSGGQPKSG VENGPKYLMK QGLRSDIESL
60 70 80 90 100
GWETTLEEPL KGRDFESGKN DETDVYGIMK RPNLVGEATK LIYESVKKVS
110 120 130 140 150
NEGRLAVTLG GDHSIAIGTV AGVLDKYPNA GLLWIDAHAD INTCSTTESG
160 170 180 190 200
NIHGCPVSFL MGLDAKNTPP SLKWVPKCLD PKKIAYIGLR DVDAAERKIL
210 220 230 240 250
KDNGIASYSM YHVDRYGLNK VIEMALEKVA PNGDEPIMVS YDVDAIDPLY
260 270 280 290 300
VPATGTPVRG GLTLREGLFL VERIAETGRL VALDVVECNP ELASHDGHVV
310
DTITTGCSIA RCALGETLL
Length:319
Mass (Da):34,535
Last modified:August 16, 2004 - v1
Checksum:i021AEE6C115B656E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG97818.1.
RefSeqiXP_455111.1. XM_455111.1.

Genome annotation databases

EnsemblFungiiCAG97818; CAG97818; KLLA0_F00704g.
GeneIDi2895828.
KEGGikla:KLLA0F00704g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG97818.1.
RefSeqiXP_455111.1. XM_455111.1.

3D structure databases

ProteinModelPortaliQ6CLS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_455111.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG97818; CAG97818; KLLA0_F00704g.
GeneIDi2895828.
KEGGikla:KLLA0F00704g.

Phylogenomic databases

eggNOGiKOG2965. Eukaryota.
COG0010. LUCA.
HOGENOMiHOG000204319.
InParanoidiQ6CLS8.
KOiK01476.
OMAiEQECDVK.
OrthoDBiEOG092C3GMN.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI_KLULA
AccessioniPrimary (citable) accession number: Q6CLS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.