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Q6CLD6

- ALG11_KLULA

UniProt

Q6CLD6 - ALG11_KLULA

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Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).By similarity

Catalytic activityi

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene namesi
Name:ALG11
Ordered Locus Names:KLLA0F03817g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CLD6.

Structurei

3D structure databases

ProteinModelPortaliQ6CLD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
HOGENOMiHOG000209670.
InParanoidiQ6CLD6.
KOiK03844.
OMAiGMAGSCS.
OrthoDBiEOG7673KQ.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
[Graphical view]
PfamiPF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CLD6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLADFVTYV FGSLLAGLVT LKVLSSFIPS LLVTLPAKVR LRVNNSLLKC
60 70 80 90 100
SNNLNRIPVL DFGWKNSSVR RAFILASERP SDYTNKIYGD RVHIAYNDRI
110 120 130 140 150
KRESFVNKLG FDSKRKLLGF FHPYCNAGGG GEKVLWKAVE TSLNQDKNNI
160 170 180 190 200
CVIYTGDTDV NGSDILNSVR RRFEYDLDSD RIVFIFLQKR RLVESKSWPK
210 220 230 240 250
FTLLGQAYGS IILSIEALTT LAPDYWIDTM GYPFAYPFVS LFARIPIVTY
260 270 280 290 300
THYPVISTDM LQKLKTMPGF HTNFKLIGKY VYWKIFMLAY KFSGLFVEIA
310 320 330 340 350
STNSTWTYNH IKSIWSSTKN IHIIYPPCST ESLIEGCDKS DPVKRLNQAV
360 370 380 390 400
VIAQFRPEKR HELILSSFSS FIDATTKKDL IPKIIFIGST RNVEDREYVE
410 420 430 440 450
TLKKYAFEAL KIPTHLVDFK TDCKYDDMKS ILYSSWFGIN AMWNEHFGIA
460 470 480 490 500
VVEYMASGLI PLCHASAGPL YDIVVPWDSK KNEQSTDKAN ETGFFFIDET
510 520 530 540 550
DPDFLAKDSS KYSSLRTLFA QVSKLNTVQR IDISNRAKMC SLSKFSDSEF
560 570
ERSWNEVLEE LNLTHNRMFS
Length:570
Mass (Da):65,348
Last modified:August 16, 2004 - v1
Checksum:i425A2A8D81205E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG97961.1.
RefSeqiXP_455253.1. XM_455253.1.

Genome annotation databases

GeneIDi2895341.
KEGGikla:KLLA0F03817g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG97961.1 .
RefSeqi XP_455253.1. XM_455253.1.

3D structure databases

ProteinModelPortali Q6CLD6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CLD6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895341.
KEGGi kla:KLLA0F03817g.

Phylogenomic databases

eggNOGi COG0438.
HOGENOMi HOG000209670.
InParanoidi Q6CLD6.
KOi K03844.
OMAi GMAGSCS.
OrthoDBi EOG7673KQ.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Family and domain databases

InterProi IPR001296. Glyco_trans_1.
[Graphical view ]
Pfami PF00534. Glycos_transf_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiALG11_KLULA
AccessioniPrimary (citable) accession number: Q6CLD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3