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Q6CLD6 (ALG11_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

EC=2.4.1.131
Alternative name(s):
Alpha-1,2-mannosyltransferase ALG11
Asparagine-linked glycosylation protein 11
Glycolipid 2-alpha-mannosyltransferase
Gene names
Name:ALG11
Ordered Locus Names:KLLA0F03817g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.

Catalytic activity

2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathway

Protein modification; protein glycosylation.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the glycosyltransferase group 1 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein glycosylation

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionGDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
PRO_0000080276

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane230 – 25021Helical; Potential

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation3031N-linked (GlcNAc...) Potential
Glycosylation4901N-linked (GlcNAc...) Potential
Glycosylation5621N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CLD6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 425A2A8D81205E1F

FASTA57065,348
        10         20         30         40         50         60 
MKLADFVTYV FGSLLAGLVT LKVLSSFIPS LLVTLPAKVR LRVNNSLLKC SNNLNRIPVL 

        70         80         90        100        110        120 
DFGWKNSSVR RAFILASERP SDYTNKIYGD RVHIAYNDRI KRESFVNKLG FDSKRKLLGF 

       130        140        150        160        170        180 
FHPYCNAGGG GEKVLWKAVE TSLNQDKNNI CVIYTGDTDV NGSDILNSVR RRFEYDLDSD 

       190        200        210        220        230        240 
RIVFIFLQKR RLVESKSWPK FTLLGQAYGS IILSIEALTT LAPDYWIDTM GYPFAYPFVS 

       250        260        270        280        290        300 
LFARIPIVTY THYPVISTDM LQKLKTMPGF HTNFKLIGKY VYWKIFMLAY KFSGLFVEIA 

       310        320        330        340        350        360 
STNSTWTYNH IKSIWSSTKN IHIIYPPCST ESLIEGCDKS DPVKRLNQAV VIAQFRPEKR 

       370        380        390        400        410        420 
HELILSSFSS FIDATTKKDL IPKIIFIGST RNVEDREYVE TLKKYAFEAL KIPTHLVDFK 

       430        440        450        460        470        480 
TDCKYDDMKS ILYSSWFGIN AMWNEHFGIA VVEYMASGLI PLCHASAGPL YDIVVPWDSK 

       490        500        510        520        530        540 
KNEQSTDKAN ETGFFFIDET DPDFLAKDSS KYSSLRTLFA QVSKLNTVQR IDISNRAKMC 

       550        560        570 
SLSKFSDSEF ERSWNEVLEE LNLTHNRMFS 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382126 Genomic DNA. Translation: CAG97961.1.
RefSeqXP_455253.1. XM_455253.1.

3D structure databases

ProteinModelPortalQ6CLD6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CLD6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895341.
KEGGkla:KLLA0F03817g.

Phylogenomic databases

eggNOGCOG0438.
HOGENOMHOG000209670.
KOK03844.
OMAGMAGSCS.
OrthoDBEOG7673KQ.

Enzyme and pathway databases

UniPathwayUPA00378.

Family and domain databases

InterProIPR001296. Glyco_trans_1.
[Graphical view]
PfamPF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALG11_KLULA
AccessionPrimary (citable) accession number: Q6CLD6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways