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Q6CLD6

- ALG11_KLULA

UniProt

Q6CLD6 - ALG11_KLULA

Protein

GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Gene

ALG11

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum By similarity.By similarity

    Catalytic activityi

    2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (EC:2.4.1.131)
    Alternative name(s):
    Alpha-1,2-mannosyltransferase ALG11
    Asparagine-linked glycosylation protein 11
    Glycolipid 2-alpha-mannosyltransferase
    Gene namesi
    Name:ALG11
    Ordered Locus Names:KLLA0F03817g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome F

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferasePRO_0000080276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi490 – 4901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CLD6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CLD6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase group 1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    HOGENOMiHOG000209670.
    KOiK03844.
    OMAiGMAGSCS.
    OrthoDBiEOG7673KQ.

    Family and domain databases

    InterProiIPR001296. Glyco_trans_1.
    [Graphical view]
    PfamiPF00534. Glycos_transf_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CLD6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLADFVTYV FGSLLAGLVT LKVLSSFIPS LLVTLPAKVR LRVNNSLLKC    50
    SNNLNRIPVL DFGWKNSSVR RAFILASERP SDYTNKIYGD RVHIAYNDRI 100
    KRESFVNKLG FDSKRKLLGF FHPYCNAGGG GEKVLWKAVE TSLNQDKNNI 150
    CVIYTGDTDV NGSDILNSVR RRFEYDLDSD RIVFIFLQKR RLVESKSWPK 200
    FTLLGQAYGS IILSIEALTT LAPDYWIDTM GYPFAYPFVS LFARIPIVTY 250
    THYPVISTDM LQKLKTMPGF HTNFKLIGKY VYWKIFMLAY KFSGLFVEIA 300
    STNSTWTYNH IKSIWSSTKN IHIIYPPCST ESLIEGCDKS DPVKRLNQAV 350
    VIAQFRPEKR HELILSSFSS FIDATTKKDL IPKIIFIGST RNVEDREYVE 400
    TLKKYAFEAL KIPTHLVDFK TDCKYDDMKS ILYSSWFGIN AMWNEHFGIA 450
    VVEYMASGLI PLCHASAGPL YDIVVPWDSK KNEQSTDKAN ETGFFFIDET 500
    DPDFLAKDSS KYSSLRTLFA QVSKLNTVQR IDISNRAKMC SLSKFSDSEF 550
    ERSWNEVLEE LNLTHNRMFS 570
    Length:570
    Mass (Da):65,348
    Last modified:August 16, 2004 - v1
    Checksum:i425A2A8D81205E1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG97961.1.
    RefSeqiXP_455253.1. XM_455253.1.

    Genome annotation databases

    GeneIDi2895341.
    KEGGikla:KLLA0F03817g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG97961.1 .
    RefSeqi XP_455253.1. XM_455253.1.

    3D structure databases

    ProteinModelPortali Q6CLD6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CLD6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2895341.
    KEGGi kla:KLLA0F03817g.

    Phylogenomic databases

    eggNOGi COG0438.
    HOGENOMi HOG000209670.
    KOi K03844.
    OMAi GMAGSCS.
    OrthoDBi EOG7673KQ.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Family and domain databases

    InterProi IPR001296. Glyco_trans_1.
    [Graphical view ]
    Pfami PF00534. Glycos_transf_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiALG11_KLULA
    AccessioniPrimary (citable) accession number: Q6CLD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3