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Q6CLD3 (LKHA4_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukotriene A-4 hydrolase homolog
Short name=LTA-4 hydrolase
EC=3.3.2.6
Alternative name(s):
Leukotriene A(4) hydrolase
Gene names
Ordered Locus Names:KLLA0F03883g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length662 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA4 to form LTB4 (in vitro) By similarity.

Catalytic activity

(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Lipid metabolism; leukotriene B4 biosynthesis.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the peptidase M1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 662662Leukotriene A-4 hydrolase homolog
PRO_0000324930

Regions

Region178 – 1803Substrate binding By similarity
Region304 – 3096Substrate binding By similarity

Sites

Active site3341Proton acceptor By similarity
Active site4221Proton donor By similarity
Metal binding3331Zinc; catalytic By similarity
Metal binding3371Zinc; catalytic By similarity
Metal binding3561Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CLD3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 6098A910305A8747

FASTA66275,914
        10         20         30         40         50         60 
MLFNFYNKTS AACKSLPAKA LSNVRYFQTS PISRKMPLPP VLESRRPKES PEFDYSTLSN 

        70         80         90        100        110        120 
YKSFKVKHSQ LDVSVDFKKK TISGSVSYEI EKVKKDENTI KLDTSYLKIS KVKVDDEDDV 

       130        140        150        160        170        180 
KFKLLERKHP LGAQLIVSPS SLPEIFHLCL QFSTTADCTA LQWLDEHQTS GKPYVFSQLE 

       190        200        210        220        230        240 
AIHARSLFTC FDTPSVKSTY LANIKSELPV VFSGIQTGYD DSTKVYSFKQ EVPIPAYLIG 

       250        260        270        280        290        300 
IASGDLASAD IGPRSKVYVE PYRLKDAQWE FDGDVEKFIT TAEDIIFKYE WGTYDILVNP 

       310        320        330        340        350        360 
NSYPYGGMES PNMTFATPTL IAHDKSNIDV IAHELAHSWS GNLVTNCSWD HFWLNEGWTV 

       370        380        390        400        410        420 
YLERRITGAI HGEATRHFSS LIGWNDLEGS ISAMQNPERF SCLVQNLKDG TDPDNAFSTV 

       430        440        450        460        470        480 
PYEKGSNLLF YLENLLGGKE VFDPFIKHYF TKFARQSLDT WQFLDALFEF FHDKREILES 

       490        500        510        520        530        540 
VDWQTWLFTP GMPPKPKLIT DLADDVYALA NKWIASAQKF TEREQFEKEF SIKDISEFSS 

       550        560        570        580        590        600 
NQIVLLLDTL VQGGMPEKDT FKWSNYPEAS EIFTDIYEDK ISKSQNAEVI FRNYRLQVKS 

       610        620        630        640        650        660 
HITSSYPELA EWLGTVGRMK FVRPGYRLLN EVDRELAIKT FHRFRDSYHP ICKSLVKQDL 


GI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382126 Genomic DNA. Translation: CAG97964.1.
RefSeqXP_455256.1. XM_455256.1.

3D structure databases

HSSPHSSP built from PDB template 1HS6 based on UniProtKB P09960.
ProteinModelPortalQ6CLD3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CLD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895344.
GenomeReviewsGene locus KLLA0F03883g in contig CR382126_GR.
KEGGkla:KLLA0F03883g.

Phylogenomic databases

eggNOGfuNOG04031.
HOGENOMHBG444814.
OMAQEVKYTL.
OrthoDBEOG49KJZX.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR012777. Leukotriene_A4_hydrolase.
IPR001930. Peptidase_M1.
IPR015211. Peptidase_M1_C.
IPR014782. Peptidase_M1_N.
[Graphical view]
KOK01254.
PANTHERPTHR11533. Peptidase_M1. 1 hit.
PfamPF09127. Leuk-A4-hydro_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSPR00756. ALADIPTASE.
SUPFAMSSF48371. ARM-type_fold. 1 hit.
TIGRFAMsTIGR02411. Leuko_A4_hydro. 1 hit.
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLKHA4_KLULA
AccessionPrimary (citable) accession number: Q6CLD3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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