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Protein

Calpain-like protease palB/RIM13

Gene

RIM13

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei139 – 1391By similarity
Active sitei277 – 2771By similarity
Active sitei295 – 2951By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-like protease palB/RIM13 (EC:3.4.22.-)
Alternative name(s):
Cysteine protease RIM13
Gene namesi
Name:RIM13
Ordered Locus Names:KLLA0F07183g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Calpain-like protease palB/RIM13PRO_0000207743Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_455406.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CKY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 323242Calpain catalyticAdd
BLAST

Sequence similaritiesi

Contains 1 calpain catalytic domain.Curated

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
InParanoidiQ6CKY3.
OMAiNAREENQ.
OrthoDBiEOG74R21M.

Sequencei

Sequence statusi: Complete.

Q6CKY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGAQAMLE KQADSVWNQL YEICWNFYVK NVWDINTFKA IVDKIEKSDD
60 70 80 90 100
KQLIRFLIWF NDARKRSNFN DKFQWMTSFL YGRRYPPLGD DLVVKEPWND
110 120 130 140 150
LQQLDSIIKY GNEPIDLVKM QPDFTTEERI VQNRRVNNCS LICSLTNARE
160 170 180 190 200
ENQIKSYSVH NVFNVILHFN GSNRLVSVLR DSNFPKCSKD GAALTLFSHN
210 220 230 240 250
IEDMLIELAY FEIKNNRNYA YGGSNTATDT YLLTGWIPEI LNLGDVSFSE
260 270 280 290 300
IRKCYQFNAM LALGTDSVKG KEVTENHDFV VTSVNWKKEQ FTILNPHGTE
310 320 330 340 350
NPTVYTWDDL IKEFKWLYVN WDPYSKYTQR VKLHDRYPDK FNAYPTWTQK
360 370 380 390 400
PLMCIENKSN SIQNCHLYLE RHLLDDSILE SNLTIGEIPR SGFTAVSAEG
410 420 430 440 450
NNSGFCNMQL RLNPHETRLI FYHSDKKCNL TFHLLSNSGL VSMSKCKSDI
460 470 480 490 500
LTAESSWNIT NNQWTIGTSE YFKSPVFKLK SDGFDDTYLD FELVSQLPAK
510 520 530 540 550
VNFQIFESDD YALQRPIFKN DTYSPQIFSK HGVRLLKGRE YFIVCSIAHH
560 570 580 590 600
ITSPFIFTLR NPETKQSKFE LSPYSLGFGG LRYNEVLRCK TRITISVSNF
610 620 630 640 650
TRLFVLLFTS ASKTNGRLTL RLYEKETEEI LFEQIETRYD LSVKPFPIPN
660 670 680
IELKPASYVL EIFYNADVVI CNLGTSHRAI FESDL
Length:685
Mass (Da):79,686
Last modified:August 16, 2004 - v1
Checksum:i5F81BCC6A6648724
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98114.1.
RefSeqiXP_455406.1. XM_455406.1.

Genome annotation databases

EnsemblFungiiCAG98114; CAG98114; KLLA0_F07183g.
GeneIDi2895973.
KEGGikla:KLLA0F07183g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98114.1.
RefSeqiXP_455406.1. XM_455406.1.

3D structure databases

ProteinModelPortaliQ6CKY3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_455406.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98114; CAG98114; KLLA0_F07183g.
GeneIDi2895973.
KEGGikla:KLLA0F07183g.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
InParanoidiQ6CKY3.
OMAiNAREENQ.
OrthoDBiEOG74R21M.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPALB_KLULA
AccessioniPrimary (citable) accession number: Q6CKY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.