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Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
Ordered Locus Names:KLLA0F07931g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000022336325 – 490Nucleotide exchange factor SIL1Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6CKV0

Interactioni

Subunit structurei

Interacts with KAR2.By similarity

Protein-protein interaction databases

STRINGi284590.XP_455439.1

Structurei

3D structure databases

SMRiQ6CKV0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi487 – 490Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2160 Eukaryota
ENOG410Y90B LUCA
InParanoidiQ6CKV0
KOiK14001
OMAiSHDIEFG
OrthoDBiEOG092C3G73

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR031884 Sil1_fungi
PfamiView protein in Pfam
PF16782 SIL1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CKV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKCVNRAI YVLTVLLFSR LVVSQVVLTP SNSNADPKQK DTANTVAAVE
60 70 80 90 100
ANNDANIAKK DAESDLVIGD HLVCNTKECY PIGFVPSTEW KEIRPGQRLP
110 120 130 140 150
PGLDIRVSLE KGVREAKLPE PGSENIGNEE EDVKGLVLGA EGSTLSESEL
160 170 180 190 200
KETSEDLENE QSGFKLNNAE KESDILQQET DLKIAVSDNA EATSNEPAGH
210 220 230 240 250
EFSEDFAKIK SLMQSPDEKT WEEVETLLDD LVEFAHDYKK GFKILSNEFE
260 270 280 290 300
LLEYLSFNDT LSIQIRELAA RIIVSSLRNN PPSIDFVNEK YPQTTFKLCE
310 320 330 340 350
HLSELQASQG SKLLIKRFLS ILDVLLSRTE YVSIKDDVLW RLYQIEDPSS
360 370 380 390 400
KIKILEIIAK FYNEKNEQVI DTVQQDMKTV QKWVNELTTI IQTPELDELH
410 420 430 440 450
LRSFFHCISF IKTRFKNRVK IDSDFLNWLI DEIEVRNEKS KDDIYKRDVD
460 470 480 490
QLEFDNQLAK SRHAVFGNPN AARLKERLFD DDDTLIADEL
Length:490
Mass (Da):55,892
Last modified:August 16, 2004 - v1
Checksum:i3DB5612E46C4FC75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA Translation: CAG98147.1
RefSeqiXP_455439.1, XM_455439.1

Genome annotation databases

EnsemblFungiiCAG98147; CAG98147; KLLA0_F07931g
GeneIDi2895067
KEGGikla:KLLA0F07931g

Similar proteinsi

Entry informationi

Entry nameiSIL1_KLULA
AccessioniPrimary (citable) accession number: Q6CKV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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