Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6CKV0 (SIL1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleotide exchange factor SIL1
Gene names
Name:SIL1
Ordered Locus Names:KLLA0F07931g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.

Subunit structure

Interacts with KAR2 By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the SIL1 family.

Ontologies

Keywords
   Biological processProtein transport
Translocation
Transport
   Cellular componentEndoplasmic reticulum
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 490466Nucleotide exchange factor SIL1
PRO_0000223363

Regions

Motif487 – 4904Prevents secretion from ER Potential

Amino acid modifications

Glycosylation2581N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CKV0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 3DB5612E46C4FC75

FASTA49055,892
        10         20         30         40         50         60 
MRVKCVNRAI YVLTVLLFSR LVVSQVVLTP SNSNADPKQK DTANTVAAVE ANNDANIAKK 

        70         80         90        100        110        120 
DAESDLVIGD HLVCNTKECY PIGFVPSTEW KEIRPGQRLP PGLDIRVSLE KGVREAKLPE 

       130        140        150        160        170        180 
PGSENIGNEE EDVKGLVLGA EGSTLSESEL KETSEDLENE QSGFKLNNAE KESDILQQET 

       190        200        210        220        230        240 
DLKIAVSDNA EATSNEPAGH EFSEDFAKIK SLMQSPDEKT WEEVETLLDD LVEFAHDYKK 

       250        260        270        280        290        300 
GFKILSNEFE LLEYLSFNDT LSIQIRELAA RIIVSSLRNN PPSIDFVNEK YPQTTFKLCE 

       310        320        330        340        350        360 
HLSELQASQG SKLLIKRFLS ILDVLLSRTE YVSIKDDVLW RLYQIEDPSS KIKILEIIAK 

       370        380        390        400        410        420 
FYNEKNEQVI DTVQQDMKTV QKWVNELTTI IQTPELDELH LRSFFHCISF IKTRFKNRVK 

       430        440        450        460        470        480 
IDSDFLNWLI DEIEVRNEKS KDDIYKRDVD QLEFDNQLAK SRHAVFGNPN AARLKERLFD 

       490 
DDDTLIADEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382126 Genomic DNA. Translation: CAG98147.1.
RefSeqXP_455439.1. XM_455439.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CKV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895067.
KEGGkla:KLLA0F07931g.

Phylogenomic databases

eggNOGNOG244873.
KOK14001.
OMASHDIEFG.
OrthoDBEOG7V1G2Q.

Family and domain databases

InterProIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSIL1_KLULA
AccessionPrimary (citable) accession number: Q6CKV0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families