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Q6CKV0

- SIL1_KLULA

UniProt

Q6CKV0 - SIL1_KLULA

Protein

Nucleotide exchange factor SIL1

Gene

SIL1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.By similarity

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleotide exchange factor SIL1
    Gene namesi
    Name:SIL1
    Ordered Locus Names:KLLA0F07931g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome F

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 490466Nucleotide exchange factor SIL1PRO_0000223363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with KAR2.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CKV0.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi487 – 4904Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the SIL1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG244873.
    KOiK14001.
    OMAiSHDIEFG.
    OrthoDBiEOG7V1G2Q.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CKV0-1 [UniParc]FASTAAdd to Basket

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    MRVKCVNRAI YVLTVLLFSR LVVSQVVLTP SNSNADPKQK DTANTVAAVE    50
    ANNDANIAKK DAESDLVIGD HLVCNTKECY PIGFVPSTEW KEIRPGQRLP 100
    PGLDIRVSLE KGVREAKLPE PGSENIGNEE EDVKGLVLGA EGSTLSESEL 150
    KETSEDLENE QSGFKLNNAE KESDILQQET DLKIAVSDNA EATSNEPAGH 200
    EFSEDFAKIK SLMQSPDEKT WEEVETLLDD LVEFAHDYKK GFKILSNEFE 250
    LLEYLSFNDT LSIQIRELAA RIIVSSLRNN PPSIDFVNEK YPQTTFKLCE 300
    HLSELQASQG SKLLIKRFLS ILDVLLSRTE YVSIKDDVLW RLYQIEDPSS 350
    KIKILEIIAK FYNEKNEQVI DTVQQDMKTV QKWVNELTTI IQTPELDELH 400
    LRSFFHCISF IKTRFKNRVK IDSDFLNWLI DEIEVRNEKS KDDIYKRDVD 450
    QLEFDNQLAK SRHAVFGNPN AARLKERLFD DDDTLIADEL 490
    Length:490
    Mass (Da):55,892
    Last modified:August 16, 2004 - v1
    Checksum:i3DB5612E46C4FC75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98147.1.
    RefSeqiXP_455439.1. XM_455439.1.

    Genome annotation databases

    GeneIDi2895067.
    KEGGikla:KLLA0F07931g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98147.1 .
    RefSeqi XP_455439.1. XM_455439.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CKV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2895067.
    KEGGi kla:KLLA0F07931g.

    Phylogenomic databases

    eggNOGi NOG244873.
    KOi K14001.
    OMAi SHDIEFG.
    OrthoDBi EOG7V1G2Q.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiSIL1_KLULA
    AccessioniPrimary (citable) accession number: Q6CKV0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3