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Q6CKV0

- SIL1_KLULA

UniProt

Q6CKV0 - SIL1_KLULA

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Protein

Nucleotide exchange factor SIL1

Gene
SIL1, KLLA0F07931g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 By similarity.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:SIL1
Ordered Locus Names:KLLA0F07931g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 490466Nucleotide exchange factor SIL1PRO_0000223363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi258 – 2581N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with KAR2 By similarity.

Protein-protein interaction databases

STRINGi28985.Q6CKV0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi487 – 4904Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the SIL1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG244873.
KOiK14001.
OMAiSHDIEFG.
OrthoDBiEOG7V1G2Q.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CKV0-1 [UniParc]FASTAAdd to Basket

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MRVKCVNRAI YVLTVLLFSR LVVSQVVLTP SNSNADPKQK DTANTVAAVE    50
ANNDANIAKK DAESDLVIGD HLVCNTKECY PIGFVPSTEW KEIRPGQRLP 100
PGLDIRVSLE KGVREAKLPE PGSENIGNEE EDVKGLVLGA EGSTLSESEL 150
KETSEDLENE QSGFKLNNAE KESDILQQET DLKIAVSDNA EATSNEPAGH 200
EFSEDFAKIK SLMQSPDEKT WEEVETLLDD LVEFAHDYKK GFKILSNEFE 250
LLEYLSFNDT LSIQIRELAA RIIVSSLRNN PPSIDFVNEK YPQTTFKLCE 300
HLSELQASQG SKLLIKRFLS ILDVLLSRTE YVSIKDDVLW RLYQIEDPSS 350
KIKILEIIAK FYNEKNEQVI DTVQQDMKTV QKWVNELTTI IQTPELDELH 400
LRSFFHCISF IKTRFKNRVK IDSDFLNWLI DEIEVRNEKS KDDIYKRDVD 450
QLEFDNQLAK SRHAVFGNPN AARLKERLFD DDDTLIADEL 490
Length:490
Mass (Da):55,892
Last modified:August 16, 2004 - v1
Checksum:i3DB5612E46C4FC75
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98147.1.
RefSeqiXP_455439.1. XM_455439.1.

Genome annotation databases

GeneIDi2895067.
KEGGikla:KLLA0F07931g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98147.1 .
RefSeqi XP_455439.1. XM_455439.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CKV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895067.
KEGGi kla:KLLA0F07931g.

Phylogenomic databases

eggNOGi NOG244873.
KOi K14001.
OMAi SHDIEFG.
OrthoDBi EOG7V1G2Q.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSIL1_KLULA
AccessioniPrimary (citable) accession number: Q6CKV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3