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Protein

Acyl-coenzyme A oxidase

Gene

POX1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FADBy similarity

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase
Gene namesi
Name:POX1
Ordered Locus Names:KLLA0F09933g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Acyl-coenzyme A oxidasePRO_0000204699Add
BLAST

Proteomic databases

PRIDEiQ6CKK7.

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CKK7.

Structurei

3D structure databases

ProteinModelPortaliQ6CKK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000181256.
InParanoidiQ6CKK7.
KOiK00232.
OMAiEIRKECI.
OrthoDBiEOG7P02SG.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CKK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRQSTVDQN QSTYNAKNFI TKERQESKLD IDQLNVFLEN GEQEAKLTHD
60 70 80 90 100
LIEEIINDPI LKTDTDHYDI TKSQEREITA RRIARLSLYM EHDVKTKQRE
110 120 130 140 150
FKDDLVKNLE RKDSKLLTNK DLSIFDRRLS LVANIDPGLS TRIGVHLGLF
160 170 180 190 200
GNCIKGNGTD EQIHYWLQEK GALLLKGIYG CFAMTELGHG SNVAQLQTTA
210 220 230 240 250
TYDPSSDTFK INTPDLLATK WWIGGAAHSA THTTAYARLI VNGKDYGVKT
260 270 280 290 300
FVVPLRDEKT LNLLPGIMIG DIGAKMGRDG IDNGWIQFKN VVIPRQFMLQ
310 320 330 340 350
RFTKVIPGSP PKVQTQPLLD QISGYSALLS GRVNMVMDSF RFGSKFAIIA
360 370 380 390 400
TRYAVGRQQF GPEGNETQLI DYPLHQYRVL PQLALCYLVA PTAHKLMGTY
410 420 430 440 450
ISTLMELHQA GADKAKLINV SNKLKDLFID SASLKATNTW LVAKLIDDLR
460 470 480 490 500
QTCGGHGYSS YNGFGKGYND WVVQCTWEGD NNILSLTSAK SIVKKFADIS
510 520 530 540 550
RGKNTTVTTD SLKYLTPQFI GKSLSKDLTF KFDNKKDFTE IWAVMIIRLI
560 570 580 590 600
HHVVELISKG TKIDSLSKTL VQISKFHAIH SMLLTYQDKL NNESEASVKD
610 620 630 640 650
AYTKGYLWKL YELFSLYFID QHLGEFLLLK VVTSDQMSQV LQPRLLQLLP
660 670 680 690 700
EIRKECIALT DAFKLPDAMI NAPIGYYDGD IYHNYFNEVT NNNKLEPDGA
710 720 730
GRPPYYPLLT SMLGRDDFQN RLGGSFESET LDSLLK
Length:736
Mass (Da):83,144
Last modified:August 16, 2004 - v1
Checksum:i32A5B2C0C7CA3E54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98240.1.
RefSeqiXP_455532.1. XM_455532.1.

Genome annotation databases

GeneIDi2895011.
KEGGikla:KLLA0F09933g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98240.1.
RefSeqiXP_455532.1. XM_455532.1.

3D structure databases

ProteinModelPortaliQ6CKK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi28985.Q6CKK7.

Proteomic databases

PRIDEiQ6CKK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2895011.
KEGGikla:KLLA0F09933g.

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000181256.
InParanoidiQ6CKK7.
KOiK00232.
OMAiEIRKECI.
OrthoDBiEOG7P02SG.

Enzyme and pathway databases

UniPathwayiUPA00661.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiACOX_KLULA
AccessioniPrimary (citable) accession number: Q6CKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.