Reviewed, UniProtKB/Swiss-Prot Q6CKK7 (ACOX_KLULA)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase
      Short name=Acyl-CoA oxidase
    EC=1.3.3.6

Gene names

Name:	POX1
Ordered Locus Names:	KLLA0F09933g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	736 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD By similarity.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 736	736	Acyl-coenzyme A oxidase		PRO_0000204699

Sequences

	Sequence		Length	Mass (Da)
	Q6CKK7-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 32A5B2C0C7CA3E54	FASTA	736	83,144
	10 20 30 40 50 60 MTRQSTVDQN QSTYNAKNFI TKERQESKLD IDQLNVFLEN GEQEAKLTHD LIEEIINDPI 70 80 90 100 110 120 LKTDTDHYDI TKSQEREITA RRIARLSLYM EHDVKTKQRE FKDDLVKNLE RKDSKLLTNK 130 140 150 160 170 180 DLSIFDRRLS LVANIDPGLS TRIGVHLGLF GNCIKGNGTD EQIHYWLQEK GALLLKGIYG 190 200 210 220 230 240 CFAMTELGHG SNVAQLQTTA TYDPSSDTFK INTPDLLATK WWIGGAAHSA THTTAYARLI 250 260 270 280 290 300 VNGKDYGVKT FVVPLRDEKT LNLLPGIMIG DIGAKMGRDG IDNGWIQFKN VVIPRQFMLQ 310 320 330 340 350 360 RFTKVIPGSP PKVQTQPLLD QISGYSALLS GRVNMVMDSF RFGSKFAIIA TRYAVGRQQF 370 380 390 400 410 420 GPEGNETQLI DYPLHQYRVL PQLALCYLVA PTAHKLMGTY ISTLMELHQA GADKAKLINV 430 440 450 460 470 480 SNKLKDLFID SASLKATNTW LVAKLIDDLR QTCGGHGYSS YNGFGKGYND WVVQCTWEGD 490 500 510 520 530 540 NNILSLTSAK SIVKKFADIS RGKNTTVTTD SLKYLTPQFI GKSLSKDLTF KFDNKKDFTE 550 560 570 580 590 600 IWAVMIIRLI HHVVELISKG TKIDSLSKTL VQISKFHAIH SMLLTYQDKL NNESEASVKD 610 620 630 640 650 660 AYTKGYLWKL YELFSLYFID QHLGEFLLLK VVTSDQMSQV LQPRLLQLLP EIRKECIALT 670 680 690 700 710 720 DAFKLPDAMI NAPIGYYDGD IYHNYFNEVT NNNKLEPDGA GRPPYYPLLT SMLGRDDFQN 730 RLGGSFESET LDSLLK

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR382126 Genomic DNA. Translation: CAG98240.1.
RefSeq	XP_455532.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CKK7.
Genome annotation databases
GeneID	2895011.
GenomeReviews	Gene locus KLLA0F09933g in contig CR382126_GR.
KEGG	kla:KLLA0F09933g.
Phylogenomic databases
HOGENOM	Q6CKK7.
OMA	ISGYSAL.
Enzyme and pathway databases
BRENDA	1.3.3.6. 74088.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX_KLULA

Accession

Primary (citable) accession number: Q6CKK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)