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Q6CKK7 (ACOX_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-coenzyme A oxidase

Short name=Acyl-CoA oxidase
EC=1.3.3.6
Gene names
Name:POX1
Ordered Locus Names:KLLA0F09933g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length736 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactor

FAD By similarity.

Pathway

Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
   Biological processFatty acid metabolism
Lipid metabolism
   Cellular componentPeroxisome
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid beta-oxidation using acyl-CoA oxidase

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

acyl-CoA oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 736736Acyl-coenzyme A oxidase
PRO_0000204699

Sequences

Sequence LengthMass (Da)Tools
Q6CKK7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 32A5B2C0C7CA3E54

FASTA73683,144
        10         20         30         40         50         60 
MTRQSTVDQN QSTYNAKNFI TKERQESKLD IDQLNVFLEN GEQEAKLTHD LIEEIINDPI 

        70         80         90        100        110        120 
LKTDTDHYDI TKSQEREITA RRIARLSLYM EHDVKTKQRE FKDDLVKNLE RKDSKLLTNK 

       130        140        150        160        170        180 
DLSIFDRRLS LVANIDPGLS TRIGVHLGLF GNCIKGNGTD EQIHYWLQEK GALLLKGIYG 

       190        200        210        220        230        240 
CFAMTELGHG SNVAQLQTTA TYDPSSDTFK INTPDLLATK WWIGGAAHSA THTTAYARLI 

       250        260        270        280        290        300 
VNGKDYGVKT FVVPLRDEKT LNLLPGIMIG DIGAKMGRDG IDNGWIQFKN VVIPRQFMLQ 

       310        320        330        340        350        360 
RFTKVIPGSP PKVQTQPLLD QISGYSALLS GRVNMVMDSF RFGSKFAIIA TRYAVGRQQF 

       370        380        390        400        410        420 
GPEGNETQLI DYPLHQYRVL PQLALCYLVA PTAHKLMGTY ISTLMELHQA GADKAKLINV 

       430        440        450        460        470        480 
SNKLKDLFID SASLKATNTW LVAKLIDDLR QTCGGHGYSS YNGFGKGYND WVVQCTWEGD 

       490        500        510        520        530        540 
NNILSLTSAK SIVKKFADIS RGKNTTVTTD SLKYLTPQFI GKSLSKDLTF KFDNKKDFTE 

       550        560        570        580        590        600 
IWAVMIIRLI HHVVELISKG TKIDSLSKTL VQISKFHAIH SMLLTYQDKL NNESEASVKD 

       610        620        630        640        650        660 
AYTKGYLWKL YELFSLYFID QHLGEFLLLK VVTSDQMSQV LQPRLLQLLP EIRKECIALT 

       670        680        690        700        710        720 
DAFKLPDAMI NAPIGYYDGD IYHNYFNEVT NNNKLEPDGA GRPPYYPLLT SMLGRDDFQN 

       730 
RLGGSFESET LDSLLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382126 Genomic DNA. Translation: CAG98240.1.
RefSeqXP_455532.1. XM_455532.1.

3D structure databases

ProteinModelPortalQ6CKK7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CKK7.

Proteomic databases

PRIDEQ6CKK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895011.
KEGGkla:KLLA0F09933g.

Phylogenomic databases

eggNOGCOG1960.
HOGENOMHOG000181256.
KOK00232.
OMAEIRKECI.
OrthoDBEOG7P02SG.

Enzyme and pathway databases

UniPathwayUPA00661.

Family and domain databases

Gene3D1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACOX_KLULA
AccessionPrimary (citable) accession number: Q6CKK7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways