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Q6CKK7

- ACOX_KLULA

UniProt

Q6CKK7 - ACOX_KLULA

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Protein

Acyl-coenzyme A oxidase

Gene
POX1, KLLA0F09933g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

Cofactori

FAD By similarity.

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. acyl-CoA oxidase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase (EC:1.3.3.6)
Short name:
Acyl-CoA oxidase
Gene namesi
Name:POX1
Ordered Locus Names:KLLA0F09933g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Acyl-coenzyme A oxidasePRO_0000204699Add
BLAST

Proteomic databases

PRIDEiQ6CKK7.

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CKK7.

Structurei

3D structure databases

ProteinModelPortaliQ6CKK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.

Phylogenomic databases

eggNOGiCOG1960.
HOGENOMiHOG000181256.
KOiK00232.
OMAiEIRKECI.
OrthoDBiEOG7P02SG.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CKK7-1 [UniParc]FASTAAdd to Basket

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MTRQSTVDQN QSTYNAKNFI TKERQESKLD IDQLNVFLEN GEQEAKLTHD    50
LIEEIINDPI LKTDTDHYDI TKSQEREITA RRIARLSLYM EHDVKTKQRE 100
FKDDLVKNLE RKDSKLLTNK DLSIFDRRLS LVANIDPGLS TRIGVHLGLF 150
GNCIKGNGTD EQIHYWLQEK GALLLKGIYG CFAMTELGHG SNVAQLQTTA 200
TYDPSSDTFK INTPDLLATK WWIGGAAHSA THTTAYARLI VNGKDYGVKT 250
FVVPLRDEKT LNLLPGIMIG DIGAKMGRDG IDNGWIQFKN VVIPRQFMLQ 300
RFTKVIPGSP PKVQTQPLLD QISGYSALLS GRVNMVMDSF RFGSKFAIIA 350
TRYAVGRQQF GPEGNETQLI DYPLHQYRVL PQLALCYLVA PTAHKLMGTY 400
ISTLMELHQA GADKAKLINV SNKLKDLFID SASLKATNTW LVAKLIDDLR 450
QTCGGHGYSS YNGFGKGYND WVVQCTWEGD NNILSLTSAK SIVKKFADIS 500
RGKNTTVTTD SLKYLTPQFI GKSLSKDLTF KFDNKKDFTE IWAVMIIRLI 550
HHVVELISKG TKIDSLSKTL VQISKFHAIH SMLLTYQDKL NNESEASVKD 600
AYTKGYLWKL YELFSLYFID QHLGEFLLLK VVTSDQMSQV LQPRLLQLLP 650
EIRKECIALT DAFKLPDAMI NAPIGYYDGD IYHNYFNEVT NNNKLEPDGA 700
GRPPYYPLLT SMLGRDDFQN RLGGSFESET LDSLLK 736
Length:736
Mass (Da):83,144
Last modified:August 16, 2004 - v1
Checksum:i32A5B2C0C7CA3E54
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98240.1.
RefSeqiXP_455532.1. XM_455532.1.

Genome annotation databases

GeneIDi2895011.
KEGGikla:KLLA0F09933g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98240.1 .
RefSeqi XP_455532.1. XM_455532.1.

3D structure databases

ProteinModelPortali Q6CKK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CKK7.

Proteomic databases

PRIDEi Q6CKK7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895011.
KEGGi kla:KLLA0F09933g.

Phylogenomic databases

eggNOGi COG1960.
HOGENOMi HOG000181256.
KOi K00232.
OMAi EIRKECI.
OrthoDBi EOG7P02SG.

Enzyme and pathway databases

UniPathwayi UPA00661 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR029320. Acyl-CoA_ox_N.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF01756. ACOX. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF14749. Acyl-CoA_ox_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
SUPFAMi SSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiACOX_KLULA
AccessioniPrimary (citable) accession number: Q6CKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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