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Q6CKK7

- ACOX_KLULA

UniProt

Q6CKK7 - ACOX_KLULA

Protein

Acyl-coenzyme A oxidase

Gene

POX1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.

    Cofactori

    FAD.By similarity

    Pathwayi

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. acyl-CoA oxidase activity Source: UniProtKB-EC
    3. flavin adenine dinucleotide binding Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation using acyl-CoA oxidase Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00661.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-coenzyme A oxidase (EC:1.3.3.6)
    Short name:
    Acyl-CoA oxidase
    Gene namesi
    Name:POX1
    Ordered Locus Names:KLLA0F09933g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome F

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 736736Acyl-coenzyme A oxidasePRO_0000204699Add
    BLAST

    Proteomic databases

    PRIDEiQ6CKK7.

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CKK7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CKK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    HOGENOMiHOG000181256.
    KOiK00232.
    OMAiEIRKECI.
    OrthoDBiEOG7P02SG.

    Family and domain databases

    Gene3Di1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProiIPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6CKK7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRQSTVDQN QSTYNAKNFI TKERQESKLD IDQLNVFLEN GEQEAKLTHD    50
    LIEEIINDPI LKTDTDHYDI TKSQEREITA RRIARLSLYM EHDVKTKQRE 100
    FKDDLVKNLE RKDSKLLTNK DLSIFDRRLS LVANIDPGLS TRIGVHLGLF 150
    GNCIKGNGTD EQIHYWLQEK GALLLKGIYG CFAMTELGHG SNVAQLQTTA 200
    TYDPSSDTFK INTPDLLATK WWIGGAAHSA THTTAYARLI VNGKDYGVKT 250
    FVVPLRDEKT LNLLPGIMIG DIGAKMGRDG IDNGWIQFKN VVIPRQFMLQ 300
    RFTKVIPGSP PKVQTQPLLD QISGYSALLS GRVNMVMDSF RFGSKFAIIA 350
    TRYAVGRQQF GPEGNETQLI DYPLHQYRVL PQLALCYLVA PTAHKLMGTY 400
    ISTLMELHQA GADKAKLINV SNKLKDLFID SASLKATNTW LVAKLIDDLR 450
    QTCGGHGYSS YNGFGKGYND WVVQCTWEGD NNILSLTSAK SIVKKFADIS 500
    RGKNTTVTTD SLKYLTPQFI GKSLSKDLTF KFDNKKDFTE IWAVMIIRLI 550
    HHVVELISKG TKIDSLSKTL VQISKFHAIH SMLLTYQDKL NNESEASVKD 600
    AYTKGYLWKL YELFSLYFID QHLGEFLLLK VVTSDQMSQV LQPRLLQLLP 650
    EIRKECIALT DAFKLPDAMI NAPIGYYDGD IYHNYFNEVT NNNKLEPDGA 700
    GRPPYYPLLT SMLGRDDFQN RLGGSFESET LDSLLK 736
    Length:736
    Mass (Da):83,144
    Last modified:August 16, 2004 - v1
    Checksum:i32A5B2C0C7CA3E54
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98240.1.
    RefSeqiXP_455532.1. XM_455532.1.

    Genome annotation databases

    GeneIDi2895011.
    KEGGikla:KLLA0F09933g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98240.1 .
    RefSeqi XP_455532.1. XM_455532.1.

    3D structure databases

    ProteinModelPortali Q6CKK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CKK7.

    Proteomic databases

    PRIDEi Q6CKK7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2895011.
    KEGGi kla:KLLA0F09933g.

    Phylogenomic databases

    eggNOGi COG1960.
    HOGENOMi HOG000181256.
    KOi K00232.
    OMAi EIRKECI.
    OrthoDBi EOG7P02SG.

    Enzyme and pathway databases

    UniPathwayi UPA00661 .

    Family and domain databases

    Gene3Di 1.10.540.10. 1 hit.
    2.40.110.10. 1 hit.
    InterProi IPR029320. Acyl-CoA_ox_N.
    IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR012258. Acyl-CoA_oxidase.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR013786. AcylCoA_DH/ox_N.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    PF14749. Acyl-CoA_ox_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000168. Acyl-CoA_oxidase. 1 hit.
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiACOX_KLULA
    AccessioniPrimary (citable) accession number: Q6CKK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3