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Q6CKK4

- KEX1_KLULA

UniProt

Q6CKK4 - KEX1_KLULA

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891By similarity
Active sitei406 – 4061By similarity
Active sitei470 – 4701By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:KLLA0F09999g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 642623Pheromone-processing carboxypeptidase KEX1PRO_0000411921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CKK4.

Structurei

3D structure databases

ProteinModelPortaliQ6CKK4.
SMRiQ6CKK4. Positions 21-506.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 544525LumenalSequence AnalysisAdd
BLAST
Topological domaini566 – 64277CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei545 – 56521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 6610Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiSVYNASH.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CKK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLWLFFVQT VLLIQCALGG LPNAKDYLVA PDLLPGLNDV KDKELIPEMH
60 70 80 90 100
AGHIPLDDGD DDDDDDEKNY FFWKFHDLAN QTSVVASKTL IIWLNGGPGC
110 120 130 140 150
SSLDGALMES GALRIDDDGE AYLNPGSWHT RGDIVFVDQP AGTGFSTVGD
160 170 180 190 200
SKYDKDLNQV SKHFMKFLKN YFKIFPDDLD KDLVLAGESY AGQYIPFFAN
210 220 230 240 250
EILKFNSKLD KDDNEEESRS GKKYNLKSLL IGNGWIDPDQ QSLSYIPFAL
260 270 280 290 300
ENNLISTKAD YFPDLLNMHS RCQNLVNNNG GKKFSFDECE DILTKILYYT
310 320 330 340 350
RRKTDENGNK VPSNQECTNI YDFRLFDSYP ACGSNWPDDL PSVSKFLGKP
360 370 380 390 400
GVMDSLHLDV DKVPHWRECD SKVSSHLKNK NTQPSIHLLP NLLKHMQIFL
410 420 430 440 450
FNGDKDIICN SRGVQDLIKN MKWNNHTGFT NDAEYYDWQY YDQFTDDTIS
460 470 480 490 500
AGFVKHESNL TYVSVYNASH MVPYDNALIS RGIMDIYLKD VELVVGKDNQ
510 520 530 540 550
DDVIISKDFV VHSDHSTGEE ELSADQKQDE DENSHKDRHR NSDKFEIAVI
560 570 580 590 600
LLVVFSITGT IAYYFLRERF RKQIHAILID PENRPPSSNK SVAWADDIEN
610 620 630 640
QGDDFKLSID EAPSTADKPA KNKSGYTKVP NTDDDSFELD NL
Length:642
Mass (Da):72,916
Last modified:August 16, 2004 - v1
Checksum:i72DB7F3D4A858215
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98243.1.
RefSeqiXP_455535.1. XM_455535.1.

Genome annotation databases

GeneIDi2895014.
KEGGikla:KLLA0F09999g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98243.1 .
RefSeqi XP_455535.1. XM_455535.1.

3D structure databases

ProteinModelPortali Q6CKK4.
SMRi Q6CKK4. Positions 21-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CKK4.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895014.
KEGGi kla:KLLA0F09999g.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi SVYNASH.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKEX1_KLULA
AccessioniPrimary (citable) accession number: Q6CKK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3