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Q6CKK4

- KEX1_KLULA

UniProt

Q6CKK4 - KEX1_KLULA

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei189 – 1891By similarity
    Active sitei406 – 4061By similarity
    Active sitei470 – 4701By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:KLLA0F09999g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome F

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 642623Pheromone-processing carboxypeptidase KEX1PRO_0000411921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi467 – 4671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi28985.Q6CKK4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CKK4.
    SMRiQ6CKK4. Positions 21-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 544525LumenalSequence AnalysisAdd
    BLAST
    Topological domaini566 – 64277CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei545 – 56521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi57 – 6610Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiSVYNASH.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CKK4-1 [UniParc]FASTAAdd to Basket

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    MSLWLFFVQT VLLIQCALGG LPNAKDYLVA PDLLPGLNDV KDKELIPEMH    50
    AGHIPLDDGD DDDDDDEKNY FFWKFHDLAN QTSVVASKTL IIWLNGGPGC 100
    SSLDGALMES GALRIDDDGE AYLNPGSWHT RGDIVFVDQP AGTGFSTVGD 150
    SKYDKDLNQV SKHFMKFLKN YFKIFPDDLD KDLVLAGESY AGQYIPFFAN 200
    EILKFNSKLD KDDNEEESRS GKKYNLKSLL IGNGWIDPDQ QSLSYIPFAL 250
    ENNLISTKAD YFPDLLNMHS RCQNLVNNNG GKKFSFDECE DILTKILYYT 300
    RRKTDENGNK VPSNQECTNI YDFRLFDSYP ACGSNWPDDL PSVSKFLGKP 350
    GVMDSLHLDV DKVPHWRECD SKVSSHLKNK NTQPSIHLLP NLLKHMQIFL 400
    FNGDKDIICN SRGVQDLIKN MKWNNHTGFT NDAEYYDWQY YDQFTDDTIS 450
    AGFVKHESNL TYVSVYNASH MVPYDNALIS RGIMDIYLKD VELVVGKDNQ 500
    DDVIISKDFV VHSDHSTGEE ELSADQKQDE DENSHKDRHR NSDKFEIAVI 550
    LLVVFSITGT IAYYFLRERF RKQIHAILID PENRPPSSNK SVAWADDIEN 600
    QGDDFKLSID EAPSTADKPA KNKSGYTKVP NTDDDSFELD NL 642
    Length:642
    Mass (Da):72,916
    Last modified:August 16, 2004 - v1
    Checksum:i72DB7F3D4A858215
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98243.1.
    RefSeqiXP_455535.1. XM_455535.1.

    Genome annotation databases

    GeneIDi2895014.
    KEGGikla:KLLA0F09999g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98243.1 .
    RefSeqi XP_455535.1. XM_455535.1.

    3D structure databases

    ProteinModelPortali Q6CKK4.
    SMRi Q6CKK4. Positions 21-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CKK4.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2895014.
    KEGGi kla:KLLA0F09999g.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi SVYNASH.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiKEX1_KLULA
    AccessioniPrimary (citable) accession number: Q6CKK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3