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Q6CKK4

- KEX1_KLULA

UniProt

Q6CKK4 - KEX1_KLULA

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Protein
Pheromone-processing carboxypeptidase KEX1
Gene
KEX1, KLLA0F09999g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei189 – 1891 By similarity
Active sitei406 – 4061 By similarity
Active sitei470 – 4701 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:KLLA0F09999g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 544525Lumenal Reviewed prediction
Add
BLAST
Transmembranei545 – 56521Helical; Reviewed prediction
Add
BLAST
Topological domaini566 – 64277Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 642623Pheromone-processing carboxypeptidase KEX1
PRO_0000411921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi425 – 4251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi467 – 4671N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi28985.Q6CKK4.

Structurei

3D structure databases

ProteinModelPortaliQ6CKK4.
SMRiQ6CKK4. Positions 21-506.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 6610Poly-Asp

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
KOiK01288.
OMAiSVYNASH.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CKK4-1 [UniParc]FASTAAdd to Basket

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MSLWLFFVQT VLLIQCALGG LPNAKDYLVA PDLLPGLNDV KDKELIPEMH    50
AGHIPLDDGD DDDDDDEKNY FFWKFHDLAN QTSVVASKTL IIWLNGGPGC 100
SSLDGALMES GALRIDDDGE AYLNPGSWHT RGDIVFVDQP AGTGFSTVGD 150
SKYDKDLNQV SKHFMKFLKN YFKIFPDDLD KDLVLAGESY AGQYIPFFAN 200
EILKFNSKLD KDDNEEESRS GKKYNLKSLL IGNGWIDPDQ QSLSYIPFAL 250
ENNLISTKAD YFPDLLNMHS RCQNLVNNNG GKKFSFDECE DILTKILYYT 300
RRKTDENGNK VPSNQECTNI YDFRLFDSYP ACGSNWPDDL PSVSKFLGKP 350
GVMDSLHLDV DKVPHWRECD SKVSSHLKNK NTQPSIHLLP NLLKHMQIFL 400
FNGDKDIICN SRGVQDLIKN MKWNNHTGFT NDAEYYDWQY YDQFTDDTIS 450
AGFVKHESNL TYVSVYNASH MVPYDNALIS RGIMDIYLKD VELVVGKDNQ 500
DDVIISKDFV VHSDHSTGEE ELSADQKQDE DENSHKDRHR NSDKFEIAVI 550
LLVVFSITGT IAYYFLRERF RKQIHAILID PENRPPSSNK SVAWADDIEN 600
QGDDFKLSID EAPSTADKPA KNKSGYTKVP NTDDDSFELD NL 642
Length:642
Mass (Da):72,916
Last modified:August 16, 2004 - v1
Checksum:i72DB7F3D4A858215
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98243.1.
RefSeqiXP_455535.1. XM_455535.1.

Genome annotation databases

GeneIDi2895014.
KEGGikla:KLLA0F09999g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98243.1 .
RefSeqi XP_455535.1. XM_455535.1.

3D structure databases

ProteinModelPortali Q6CKK4.
SMRi Q6CKK4. Positions 21-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CKK4.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895014.
KEGGi kla:KLLA0F09999g.

Phylogenomic databases

HOGENOMi HOG000208879.
KOi K01288.
OMAi SVYNASH.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKEX1_KLULA
AccessioniPrimary (citable) accession number: Q6CKK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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