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Protein

DNA polymerase epsilon subunit D

Gene

DPB4

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase II participates in chromosomal DNA replication.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit D (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit D
Gene namesi
Name:DPB4
Ordered Locus Names:KLLA0F19426g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216DNA polymerase epsilon subunit DPRO_0000191751Add
BLAST

Interactioni

Subunit structurei

Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi284590.XP_455952.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CJD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0870. Eukaryota.
ENOG4111QSW. LUCA.
HOGENOMiHOG000112253.
InParanoidiQ6CJD7.
KOiK02326.
OMAiTENDHVE.
OrthoDBiEOG092C4T63.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CJD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKGWRKDS EGNYPNTSYI KEQEKISIDD LLFPKSIITS LAKESLQNAF
60 70 80 90 100
QKGEEERRIT VSKDAALAMQ RSATVFVNHL LMFARMNAKD SNRKSCNDQD
110 120 130 140 150
IMAALDTLGL GALESILTGK MQEYQEAILW KKQNKVNNAV PGADGDIAME
160 170 180 190 200
DDEDDEDDDG REGADADAEP KSRADTEVQQ GNAENDKLDG PPVNQEQVPS
210
TRQNDLDLST KKQKTE
Length:216
Mass (Da):24,021
Last modified:August 16, 2004 - v1
Checksum:iDD694EA017747C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98660.1.
RefSeqiXP_455952.1. XM_455952.1.

Genome annotation databases

EnsemblFungiiCAG98660; CAG98660; KLLA0_F19426g.
GeneIDi2895512.
KEGGikla:KLLA0F19426g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98660.1.
RefSeqiXP_455952.1. XM_455952.1.

3D structure databases

ProteinModelPortaliQ6CJD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_455952.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98660; CAG98660; KLLA0_F19426g.
GeneIDi2895512.
KEGGikla:KLLA0F19426g.

Phylogenomic databases

eggNOGiKOG0870. Eukaryota.
ENOG4111QSW. LUCA.
HOGENOMiHOG000112253.
InParanoidiQ6CJD7.
KOiK02326.
OMAiTENDHVE.
OrthoDBiEOG092C4T63.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPB4_KLULA
AccessioniPrimary (citable) accession number: Q6CJD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.