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Protein

DNA polymerase epsilon subunit D

Gene

DPB4

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase II participates in chromosomal DNA replication.

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit D (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit D
Gene namesi
Name:DPB4
Ordered Locus Names:KLLA0F19426g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917511 – 216DNA polymerase epsilon subunit DAdd BLAST216

Interactioni

Subunit structurei

Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi284590.XP_455952.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CJD7.
SMRiQ6CJD7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0870. Eukaryota.
ENOG4111QSW. LUCA.
HOGENOMiHOG000112253.
InParanoidiQ6CJD7.
KOiK02326.
OMAiTANDNCK.
OrthoDBiEOG092C4T63.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CJD7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKGWRKDS EGNYPNTSYI KEQEKISIDD LLFPKSIITS LAKESLQNAF
60 70 80 90 100
QKGEEERRIT VSKDAALAMQ RSATVFVNHL LMFARMNAKD SNRKSCNDQD
110 120 130 140 150
IMAALDTLGL GALESILTGK MQEYQEAILW KKQNKVNNAV PGADGDIAME
160 170 180 190 200
DDEDDEDDDG REGADADAEP KSRADTEVQQ GNAENDKLDG PPVNQEQVPS
210
TRQNDLDLST KKQKTE
Length:216
Mass (Da):24,021
Last modified:August 16, 2004 - v1
Checksum:iDD694EA017747C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98660.1.
RefSeqiXP_455952.1. XM_455952.1.

Genome annotation databases

GeneIDi2895512.
KEGGikla:KLLA0F19426g.

Similar proteinsi

Entry informationi

Entry nameiDPB4_KLULA
AccessioniPrimary (citable) accession number: Q6CJD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome