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Reviewed, UniProtKB/Swiss-Prot Q6CJA8 (HOG1_KLULA)

Last modified November 3, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mitogen-activated protein kinase HOG1
      Short name=MAP kinase HOG1
    EC=2.7.11.24
Gene names
Name: HOG1
Ordered Locus Names: KLLA0F20053g
OrganismKluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier28985 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-173 and Tyr-175, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Mitogen-activated protein kinase HOG1
PRO_0000289694

Regions

Domain22 – 301280Protein kinase
Nucleotide binding28 – 369ATP By similarity
Motif173 – 1753TXY
Compositional bias374 – 40330Gln-rich

Sites

Active site1431Proton acceptor By similarity
Binding site511ATP By similarity

Amino acid modifications

Modified residue1731Phosphothreonine By similarity
Modified residue1751Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CJA8-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: CEA1CB7A1849891D

FASTA44450,298
        10         20         30         40         50         60 
MSNEEFIRTQ IFGTVFEITN RYTNLNPVGM GAFGLVCSAT DTLTSQPVAI KKIMKPFSTS 

        70         80         90        100        110        120 
VLAKRTYREL KLLKHLRHEN LICLEDIFLS PLEDIYFVTE LQGTDLHRLL QTRPLEKQFV 

       130        140        150        160        170        180 
QYFLYQILRG LKYVHSAGVI HRDLKPSNIL INENCDLKIC DFGLARIQDP QMTGYVSTRY 

       190        200        210        220        230        240 
YRAPEIMLTW QKYNVEVDIW SAGCIFAEMI EGKPLFPGKD HVHQFSIITD LLGSPPKDVI 

       250        260        270        280        290        300 
DTICSENTLK FVTSLPHRDP VPFSSRFQNL EPDAIDLLEK MLVFDPKKRI TAADALAHPY 

       310        320        330        340        350        360 
LSPYHDPTDE PIAEAKFDWN FNDADLPVDT WRVMMYSEIL DFHQIGDPQI NTNATFDDQV 

       370        380        390        400        410        420 
AAATVAAAEA ASKQQQQQQH QTEEQTQQTI ASTPPQAQVT PQQLESGANS NSNSNPSFSI 

       430        440 
GPDPANETLT NFANQADQYV SKFK 

« Hide

Cross-references

Sequence databases

CR382126 Genomic DNA. Translation: CAG98689.1.
RefSeqXP_455981.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2895492.
GenomeReviewsGene locus KLLA0F20053g in contig CR382126_GR.
KEGGkla:KLLA0F20053g.

Phylogenomic databases

HOGENOMQ6CJA8.
OMASEILDFH.

Enzyme and pathway databases

BRENDA2.7.11.24. 74088.

Family and domain databases

InterProIPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000425. MIP.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS01351. MAPK. 1 hit.
PS00221. MIP. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHOG1_KLULA
AccessionPrimary (citable) accession number: Q6CJA8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 16, 2004
Last modified: November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents