Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Helicase SWR1

Gene

SWR1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi790 – 797ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SWR1 (EC:3.6.4.12)
Gene namesi
Name:SWR1
Ordered Locus Names:KLLA0F21758g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000743701 – 1572Helicase SWR1Add BLAST1572

Interactioni

Subunit structurei

Component of the SWR1 chromatin-remodeling complex.By similarity

Protein-protein interaction databases

STRINGi284590.XP_456051.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CJ38.
SMRiQ6CJ38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini424 – 496HSAPROSITE-ProRule annotationAdd BLAST73
Domaini777 – 942Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1314 – 1464Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi893 – 896DEAH box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0388. Eukaryota.
KOG0391. Eukaryota.
COG0553. LUCA.
HOGENOMiHOG000186095.
InParanoidiQ6CJ38.
KOiK11681.
OMAiYFLMPSS.
OrthoDBiEOG092C1YH4.

Family and domain databases

InterProiView protein in InterPro
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CJ38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEVRDWRQL AKTRLEYELL TNELFHLWEF TSLVEYDPLF RNTSNSFKTF
60 70 80 90 100
LQERGLDVES SLEQDDMKES NASRRLKRRN VISGTADSSS DKNNIWGQVM
110 120 130 140 150
PLVDQEYSEL QEKLRASVCG RRGRKRTQQV ASVPAESEED VAVPRPNKKR
160 170 180 190 200
QTVVTAQGSA QNKLNTPVVS SPKKSLKQTA DKKSKLNKRD SSTNDISVES
210 220 230 240 250
EDPPVKDITN TGQGKSKARL KSSKAKSKKR AVKSQTELVR KQSPEIKNES
260 270 280 290 300
KRTKADPTHT NDDGNDNRKT NNKSKNIINN NESGLKTSLN TTGDIIDDEE
310 320 330 340 350
YYFTSSSEDD DNEKPRTALQ KKSLPNRLKV KLHVNAPRQT ITNPLHVLKP
360 370 380 390 400
EYADVHSFLQ SYKSLDEDVS LEEYDSYIKE QRKTAKLIRI GFERGAIKYD
410 420 430 440 450
PQTDSLQSLS LRDVMPPSNA AEPISVYYKE QSKHTFQDHL VNQGIVLSKS
460 470 480 490 500
FQDSRRSQIA KARRVAQIIE SHFKHIAGAE ERKLKEEEKR KKNLARFAMQ
510 520 530 540 550
AVKKRWTMAE KAYKVLKKDE LDQLERIQGK QHLTEMLEQS TQLLGAQLNQ
560 570 580 590 600
LDSCTYPSEA SDASSEFSAN EESDGNSDID DEMMSTSSCD SDKEGNTERI
610 620 630 640 650
GNDMELSVEE LRSKYAQLNK INDFGNETSK SAADESIFDE ASDSVSDSME
660 670 680 690 700
DSLSSSESET EDADASAQED TPGLSALLGN IDENEEDVEA DVNFDADSSS
710 720 730 740 750
DDGLDGDSSG AENNSKTEEL PSPPKSDNEL KDEKAETTES VTSPAAADPL
760 770 780 790 800
AVSDVPVPSL LRGTLRIYQK QGLNWLASLY NNKTNGILAD EMGLGKTIQT
810 820 830 840 850
ISLLAYLACE KENWGPHLIV VPTSVLLNWE MEFKRFAPGF KVLTYYGSPQ
860 870 880 890 900
QRREKRKGWN KPDAFHVCIT SYQLVVHDQH SFKRKKWQYM ILDEAHNIKN
910 920 930 940 950
FRSTRWQALL NFNTERRLLL TGTPLQNNLA ELWSLLYFLM PQTALENGKV
960 970 980 990 1000
SGFADLDAFQ QWFGRPVDKI VETGENYEQD EETKKTVSKL HQVLRPYLLR
1010 1020 1030 1040 1050
RLKADVEKQM PGKYEHIIYC RLSKRQRFLY DDFMSRAQTK ETLASGNFMS
1060 1070 1080 1090 1100
IINCLMQLRK VCNHPDLFEV RPILTSFCIE DSVSKSYCDL NNYVYNRLHE
1110 1120 1130 1140 1150
NQFETSVDLS NLNFQFTSND KTLSTNHSEK ISELQCVQPI LKEISRLKQL
1160 1170 1180 1190 1200
NENDSPVTQP DFQDLNQYYS YAKHNKINEI IGQLEHLNYM NNLRCNRRPM
1210 1220 1230 1240 1250
YGSNIVKLLT VGPKKFIDCE LTQESIKPLE TRLLEGKETI EKFAVITPPV
1260 1270 1280 1290 1300
VTLDIRERAV GVDDNNKRFE ESVKHHLVSQ MRSLENPFHQ LQTKLSVAFP
1310 1320 1330 1340 1350
DKSLLQYDCG KLQKLAQLLQ NLKDNGHRAL IFTQMTKVLD ILEQFLNFHG
1360 1370 1380 1390 1400
YLYMRLDGAT KIEDRQILTE RFNSDPRITV FILSSRSGGL GINLTGADTV
1410 1420 1430 1440 1450
IFYDSDWNPA MDKQCQDRCH RIGQTRDVHI YRFVSDHTIE SNILKKANQK
1460 1470 1480 1490 1500
RHLDNVVIQT GDFTTDYFTK LSVKDLLGAE APEDIPDDKP LLQDQKNLNK
1510 1520 1530 1540 1550
LLAQAEDEDD AKAAKSALRE VNVDNEDFQE GSVAAQDGNS DNENNEDSED
1560 1570
EYGGTSHVEE YMVRFIANGF YY
Length:1,572
Mass (Da):179,228
Last modified:August 16, 2004 - v1
Checksum:iBCD2E07B63FE0211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98759.1.
RefSeqiXP_456051.1. XM_456051.1.

Genome annotation databases

EnsemblFungiiCAG98759; CAG98759; KLLA0_F21758g.
GeneIDi2895412.
KEGGikla:KLLA0F21758g.

Entry informationi

Entry nameiSWR1_KLULA
AccessioniPrimary (citable) accession number: Q6CJ38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families