Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6CIR6

- ETR1_KLULA

UniProt

Q6CIR6 - ETR1_KLULA

Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene

ETR1

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.By similarity

    Catalytic activityi

    Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei159 – 1591NADPBy similarity
    Binding sitei375 – 3751NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi187 – 1904NADPBy similarity
    Nucleotide bindingi210 – 2123NADPBy similarity
    Nucleotide bindingi285 – 2884NADPBy similarity
    Nucleotide bindingi310 – 3123NADPBy similarity

    GO - Molecular functioni

    1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
    Gene namesi
    Name:ETR1
    Ordered Locus Names:KLLA0F24552g
    OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
    Taxonomic identifieri284590 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
    ProteomesiUP000000598: Chromosome F

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1717MitochondrionSequence AnalysisAdd
    BLAST
    Chaini18 – 382365Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000902Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi28985.Q6CIR6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CIR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0604.
    HOGENOMiHOG000294683.
    KOiK07512.
    OMAiCSTLWRV.
    OrthoDBiEOG7PS1RH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CIR6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFLSKRFL SFSQRAMSQE SLKFKSLIYS SHDSQDCTKV LKVHNYKPKK    50
    GSETSIVLKT LAFPINPSDI NQLEGVYPSK PDKVTDYSTD EPSAIAGNEG 100
    VFEVVSVPSS VSTLKPGDKV IPLQANFGTW STYRTCDKES DLIKIEGVDI 150
    YTAATVAVNG CTAYQLVNDY INWDPKGNDW LVQNAGTSSV SKIVTQIAKA 200
    KNINTLSVIR DRENFEEVAE ILEKKYGATK VISETENGEK EFGKEVLPKV 250
    LGSNAQVKLA LNSVGGKSCA NIARKLSKDG LMLTYGGMSK QPLTFPTGLF 300
    IFKGLKSHGF WVTENSKRDP ENKIKTVNEV IELYRDGKII SPKEDIRALE 350
    WDVNNASDEE VLQLITDGIK TKGTKNMVIL KW 382
    Length:382
    Mass (Da):42,256
    Last modified:August 16, 2004 - v1
    Checksum:iDE17CC6087A6A8FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98881.1.
    RefSeqiXP_456173.1. XM_456173.1.

    Genome annotation databases

    GeneIDi2895202.
    KEGGikla:KLLA0F24552g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382126 Genomic DNA. Translation: CAG98881.1 .
    RefSeqi XP_456173.1. XM_456173.1.

    3D structure databases

    ProteinModelPortali Q6CIR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 28985.Q6CIR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2895202.
    KEGGi kla:KLLA0F24552g.

    Phylogenomic databases

    eggNOGi COG0604.
    HOGENOMi HOG000294683.
    KOi K07512.
    OMAi CSTLWRV.
    OrthoDBi EOG7PS1RH.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR002085. ADH_SF_Zn-type.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiETR1_KLULA
    AccessioniPrimary (citable) accession number: Q6CIR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3