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Q6CIR6 (ETR1_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial

EC=1.3.1.38
Gene names
Name:ETR1
Ordered Locus Names:KLLA0F24552g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activity

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontrans-2-enoyl-CoA reductase (NADPH) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 1717Mitochondrion Potential
Chain18 – 382365Probable trans-2-enoyl-CoA reductase, mitochondrial
PRO_0000000902

Regions

Nucleotide binding187 – 1904NADP By similarity
Nucleotide binding210 – 2123NADP By similarity
Nucleotide binding285 – 2884NADP By similarity
Nucleotide binding310 – 3123NADP By similarity

Sites

Binding site1591NADP By similarity
Binding site3751NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CIR6 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: DE17CC6087A6A8FB

FASTA38242,256
        10         20         30         40         50         60 
MSSFLSKRFL SFSQRAMSQE SLKFKSLIYS SHDSQDCTKV LKVHNYKPKK GSETSIVLKT 

        70         80         90        100        110        120 
LAFPINPSDI NQLEGVYPSK PDKVTDYSTD EPSAIAGNEG VFEVVSVPSS VSTLKPGDKV 

       130        140        150        160        170        180 
IPLQANFGTW STYRTCDKES DLIKIEGVDI YTAATVAVNG CTAYQLVNDY INWDPKGNDW 

       190        200        210        220        230        240 
LVQNAGTSSV SKIVTQIAKA KNINTLSVIR DRENFEEVAE ILEKKYGATK VISETENGEK 

       250        260        270        280        290        300 
EFGKEVLPKV LGSNAQVKLA LNSVGGKSCA NIARKLSKDG LMLTYGGMSK QPLTFPTGLF 

       310        320        330        340        350        360 
IFKGLKSHGF WVTENSKRDP ENKIKTVNEV IELYRDGKII SPKEDIRALE WDVNNASDEE 

       370        380 
VLQLITDGIK TKGTKNMVIL KW 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382126 Genomic DNA. Translation: CAG98881.1.
RefSeqXP_456173.1. XM_456173.1.

3D structure databases

ProteinModelPortalQ6CIR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING28985.Q6CIR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2895202.
KEGGkla:KLLA0F24552g.

Phylogenomic databases

eggNOGCOG0604.
HOGENOMHOG000294683.
KOK07512.
OMACSTLWRV.
OrthoDBEOG7PS1RH.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
ProtoNetSearch...

Entry information

Entry nameETR1_KLULA
AccessionPrimary (citable) accession number: Q6CIR6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families