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Q6CIR6

- ETR1_KLULA

UniProt

Q6CIR6 - ETR1_KLULA

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Protein

Probable trans-2-enoyl-CoA reductase, mitochondrial

Gene
ETR1, KLLA0F24552g
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis By similarity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591NADP By similarity
Binding sitei375 – 3751NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi187 – 1904NADP By similarity
Nucleotide bindingi210 – 2123NADP By similarity
Nucleotide bindingi285 – 2884NADP By similarity
Nucleotide bindingi310 – 3123NADP By similarity

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Probable trans-2-enoyl-CoA reductase, mitochondrial (EC:1.3.1.38)
Gene namesi
Name:ETR1
Ordered Locus Names:KLLA0F24552g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
ProteomesiUP000000598: Chromosome F

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1717Mitochondrion Reviewed predictionAdd
BLAST
Chaini18 – 382365Probable trans-2-enoyl-CoA reductase, mitochondrialPRO_0000000902Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi28985.Q6CIR6.

Structurei

3D structure databases

ProteinModelPortaliQ6CIR6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0604.
HOGENOMiHOG000294683.
KOiK07512.
OMAiCSTLWRV.
OrthoDBiEOG7PS1RH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CIR6-1 [UniParc]FASTAAdd to Basket

« Hide

MSSFLSKRFL SFSQRAMSQE SLKFKSLIYS SHDSQDCTKV LKVHNYKPKK    50
GSETSIVLKT LAFPINPSDI NQLEGVYPSK PDKVTDYSTD EPSAIAGNEG 100
VFEVVSVPSS VSTLKPGDKV IPLQANFGTW STYRTCDKES DLIKIEGVDI 150
YTAATVAVNG CTAYQLVNDY INWDPKGNDW LVQNAGTSSV SKIVTQIAKA 200
KNINTLSVIR DRENFEEVAE ILEKKYGATK VISETENGEK EFGKEVLPKV 250
LGSNAQVKLA LNSVGGKSCA NIARKLSKDG LMLTYGGMSK QPLTFPTGLF 300
IFKGLKSHGF WVTENSKRDP ENKIKTVNEV IELYRDGKII SPKEDIRALE 350
WDVNNASDEE VLQLITDGIK TKGTKNMVIL KW 382
Length:382
Mass (Da):42,256
Last modified:August 16, 2004 - v1
Checksum:iDE17CC6087A6A8FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98881.1.
RefSeqiXP_456173.1. XM_456173.1.

Genome annotation databases

GeneIDi2895202.
KEGGikla:KLLA0F24552g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382126 Genomic DNA. Translation: CAG98881.1 .
RefSeqi XP_456173.1. XM_456173.1.

3D structure databases

ProteinModelPortali Q6CIR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 28985.Q6CIR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2895202.
KEGGi kla:KLLA0F24552g.

Phylogenomic databases

eggNOGi COG0604.
HOGENOMi HOG000294683.
KOi K07512.
OMAi CSTLWRV.
OrthoDBi EOG7PS1RH.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiETR1_KLULA
AccessioniPrimary (citable) accession number: Q6CIR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi