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Protein

ATP-dependent RNA helicase DBP10

Gene

DBP10

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi170 – 1778ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DBP10 (EC:3.6.4.13)
Gene namesi
Name:DBP10
Ordered Locus Names:KLLA0F24684g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome F

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 973973ATP-dependent RNA helicase DBP10PRO_0000232317Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi284590.XP_456179.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CIR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 329173Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini408 – 552145Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 15429Q motifAdd
BLAST
Motifi277 – 2804DEAD box

Domaini

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0337. Eukaryota.
ENOG410XQE5. LUCA.
HOGENOMiHOG000246455.
InParanoidiQ6CIR0.
KOiK14808.
OMAiFPPQPKV.
OrthoDBiEOG7FR7R5.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 3 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CIR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDSSKRALP AEDYSSEDED AFDIAGDIAL NADSEDSDIS DDDNDNIGFQ
60 70 80 90 100
AEVQDVIEFS SDEEEKEKKP KKQNKKAKVK AGPIVDSKFP SLELSDDEKK
110 120 130 140 150
ATNESDDDLN DYFNTTADAA AKHKKGSFAS FGLSKLVLIN ISKKGFRQPT
160 170 180 190 200
PIQRKTIPLI LQKRDIVGMA RTGSGKTAAF VLPMIEKLKT HSAKIGVRAV
210 220 230 240 250
ILSPSRELAI QTHRVFKEFS KGSDLRSILL TGGDSLEDQF GMMMGNPDVV
260 270 280 290 300
IATPGRFLHL KVEMNLDLKS VEYVVFDEAD RLFEMGFQEQ LNELLVAFPT
310 320 330 340 350
NRQTLLFSAT LPSSLVDFAK AGLSNPVLVR LDAETKISEN LEMLFISIKK
360 370 380 390 400
DEREANLLYL LQEAIKMPVA TESQIKKLKQ QNDADSDSDD SEDEKKKKAK
410 420 430 440 450
KAKKSKRRLP NANEMPSEKA TIVFVPTRHH VEYVTQLLKN CGYLVSYIYG
460 470 480 490 500
ALNQHARKQQ LYNFRAGLTS ILVVTDVAAR GVDIPLLANV INYSLPGSSK
510 520 530 540 550
IFIHRVGRTA RAGNRGWAFS IVSENELPYL LDLELFLGKK ILLTPMYESS
560 570 580 590 600
CQILRKKAES EGNNNFTDPK VSYTTRMVLG ACPRSEIDGM GDLYSNMIKS
610 620 630 640 650
DFELNTVKGV ALKAEKLYFR TRTPASAESM KRSKEILRSG WDEQNIYFGK
660 670 680 690 700
NAEKEKLDFL AKLQHRNNKE TVFEFARNPD DEMSVLMKRR RRQIAPIQRK
710 720 730 740 750
AKERQELLEK ERMIGLRHSI EDEILKGEDN EVGYSVPDEV LKEFEDADVL
760 770 780 790 800
LEEQENIKKK QKKTFRDPTF YLSHFAPTSD IQDKQLQISS GFTNDASNAA
810 820 830 840 850
FDLANDDKVQ VHKQTATVKW DKKRKKYVNT QGLDNKKYII GESGQKIPAS
860 870 880 890 900
FRSGKFQDWS KARKIAPLKV GARESTIPSN LLADPTSPSE RTVGGKFKHK
910 920 930 940 950
TQKAPKLPDK HRDDYAFQKK KVEAALERGV RVKGYNGPGM KQEIKSVDEI
960 970
RKLREIKEKK RSKNARPTKR RKH
Length:973
Mass (Da):110,014
Last modified:August 16, 2004 - v1
Checksum:iB5C936A83B68584D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98887.1.
RefSeqiXP_456179.1. XM_456179.1.

Genome annotation databases

EnsemblFungiiCAG98887; CAG98887; KLLA0_F24684g.
GeneIDi2895208.
KEGGikla:KLLA0F24684g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382126 Genomic DNA. Translation: CAG98887.1.
RefSeqiXP_456179.1. XM_456179.1.

3D structure databases

ProteinModelPortaliQ6CIR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284590.XP_456179.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG98887; CAG98887; KLLA0_F24684g.
GeneIDi2895208.
KEGGikla:KLLA0F24684g.

Phylogenomic databases

eggNOGiKOG0337. Eukaryota.
ENOG410XQE5. LUCA.
HOGENOMiHOG000246455.
InParanoidiQ6CIR0.
KOiK14808.
OMAiFPPQPKV.
OrthoDBiEOG7FR7R5.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 3 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBP10_KLULA
AccessioniPrimary (citable) accession number: Q6CIR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.