Reviewed, UniProtKB/Swiss-Prot Q6CIN8 (EPL1_KLULA)

Names and origin

Protein names

Recommended name:
Enhancer of polycomb-like protein 1

Gene names

Name:	EPL1
Ordered Locus Names:	KLLA0F25146g

Organism

Kluyveromyces lactis (Yeast) (Candida sphaerica) [Complete proteome]

Taxonomic identifier

28985 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M By similarity.
Subunit structure	Component of the NuA4 histone acetyltransferase complex By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the enhancer of polycomb family.

Ontologies

Keywords
Biological process	Cell cycle DNA damage DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW regulation of cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 806	806	Enhancer of polycomb-like protein 1		PRO_0000214163
Regions
	Compositional bias	377 – 401	25	Gln-rich

Sequences

	Sequence		Length	Mass (Da)
	Q6CIN8-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 366DD96D89139DFD	FASTA	806	93,398
	10 20 30 40 50 60 MPAPAVDSSR FRHRKISVKQ RLRIYKSHEI KDLEQEDVSA ISSQHQQREL MEIETGVEKN 70 80 90 100 110 120 EEKEEHLYKI LQSNQLRENK KDLFIPTPDA SKTWDEFDRF YQGEFKCPTS YIQFSAQLED 130 140 150 160 170 180 CCGTLYNMDE EDEIFLADLN KSLADSVEPL TEDEFELIMA NFESSIKDRQ PFLSMDPESI 190 200 210 220 230 240 LSFADLKPTM LKNDVGDSGV KKELAKEIGM PEDEPFLTMF DNKRPLGKRE KNMETLIELF 250 260 270 280 290 300 GEKIHDHWKQ RKISRHGCDI FPQLKSERNN DKDDNDPYVC FRRRELRQPR KTRRIDVQNS 310 320 330 340 350 360 QKLRLLCQQL EYTKDLALTV AKRERAVLEV LENEKFVFQA RAQLKTMKRK LGIDADNEDL 370 380 390 400 410 420 YSAKKQKLVS SVRTIKQQQQ LLLQKQLQIQ QQQQQQLQQQ QAAITSDSSV KRAKSSKSSK 430 440 450 460 470 480 LHKEDSGLYA DEKGSEPKKK GPKTGSNKNK EQSLSSAQEI GAQSPVANVS NVQQQQKQAS 490 500 510 520 530 540 SQVYVKLPNS KIPDIVLEDV GKLLHSKEKS TRKFVEDRMR KRKQEDGDIF FNLTDDPYNP 550 560 570 580 590 600 VFNLSIPDNV SPQDAPFSSV AGSKFEVKTS YYSPNLQNYI TGTANDIKVF NKEGEAVENN 610 620 630 640 650 660 EYKKLEFFNP FDNEIHTHSR EFPIAFRRRR GRFNMEYIDQ RKTDHNINDM LLQFIDLDGI 670 680 690 700 710 720 QKQELDNDVI NVYDSKLDDL SRSYYHWKYD SNYNIYGSKF SDEPAKLNQI SNDTQVVRFG 730 740 750 760 770 780 TMLGSKAYEQ LRDATIKYRQ EQINKRKKLN SLQQQQMLQK GQQPINNAPH SQSSSPPSHQ 790 800 DTRKNPGSTP NQSSPPKKHV TPNAAA

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382126 Genomic DNA. Translation: CAG98909.1.
RefSeq	XP_456201.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CIN8.
Genome annotation databases
GeneID	2895178.
GenomeReviews	Gene locus KLLA0F25146g in contig CR382126_GR.
KEGG	kla:KLLA0F25146g.
Phylogenomic databases
eggNOG	fuNOG05193.
HOGENOM	HBG398278.
OMA	IPTPDAS.
OrthoDB	EOG9WQ2K8.
PhylomeDB	Q6CIN8.
Family and domain databases
InterPro	IPR019542. Enhancer_of_polycomb-like. [Graphical view]
Pfam	PF10513. EPL1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPL1_KLULA

Accession

Primary (citable) accession number: Q6CIN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)