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Q6CID0 (NCB5R_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-cytochrome b5 reductase 1

EC=1.6.2.2
Alternative name(s):
Microsomal cytochrome b reductase
Gene names
Name:CBR1
Ordered Locus Names:KLLA0F27621g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes By similarity.

Catalytic activity

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactor

FAD By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass membrane protein By similarity. Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281NADH-cytochrome b5 reductase 1
PRO_0000330154

Regions

Transmembrane2 – 2221Helical; Potential
Domain37 – 141105FAD-binding FR-type
Nucleotide binding121 – 13616FAD By similarity
Nucleotide binding147 – 17933FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CID0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1FCA8AE0D3425AD2

FASTA28131,220
        10         20         30         40         50         60 
MVPGKFIFTA TFVLLCTIIA VVLEYQSKKD KPVLDKEKLQ EFPLVAKTVL THNTAIYRFG 

        70         80         90        100        110        120 
LPKSTQVLGL PIGQHISVQA NINGKDILRS YTPTSLDSDA VGHFELLIKS YEKGNISKHF 

       130        140        150        160        170        180 
AQLNIGDKIK VRGPKGFYHY QPNMNEEIGM IAGGTGIAPM YQIMKSIFAN DSDKTKVSLV 

       190        200        210        220        230        240 
YGNQTEEDIL LKKELDAFVE RKPDQFKVYY LLDKAPEAWT GGVGYITVDT MKERLPAPAE 

       250        260        270        280 
GVQLLVCGPP PMVSSIKRNA VTLGYEKAKP ISKMGDQIFV F 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382126 Genomic DNA. Translation: CAG99017.1.
RefSeqXP_456309.1. XM_456309.1.

3D structure databases

HSSPHSSP built from PDB template 2CND based on UniProtKB P17571.
ProteinModelPortalQ6CID0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2894868.
GenomeReviewsGene locus KLLA0F27621g in contig CR382126_GR.
KEGGkla:KLLA0F27621g.

Phylogenomic databases

eggNOGfuNOG05226.
HOGENOMHBG591994.
OMAEEPLILM.
OrthoDBEOG4FFH9R.

Family and domain databases

InterProIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
KOK00326.
PfamPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSPR00406. CYTB5RDTASE.
PR00371. FPNCR.
SUPFAMSSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNCB5R_KLULA
AccessionPrimary (citable) accession number: Q6CID0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families