Reviewed, UniProtKB/Swiss-Prot Q6CHE9 (NNT1_YARLI)

Names and origin

Protein names

Recommended name:
    Putative nicotinamide N-methyltransferase
    EC=2.1.1.1

Gene names

Name:	NNT1
Ordered Locus Names:	YALI0A09636g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Putative nicotinamide N-methyltransferase involved in rDNA silencing and in lifespan determination By similarity.
Catalytic activity	S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NNT1 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro nicotinamide N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Putative nicotinamide N-methyltransferase		PRO_0000096900

Sequences

	Sequence		Length	Mass (Da)
	Q6CHE9-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 53976572AA2530CF	FASTA	273	30,729
	10 20 30 40 50 60 MSDIEDLASG GLFDEPKDFY KPEEQPGSDS YARQEKHVAA SEYKEPTNFN LRLTAKNPLW 70 80 90 100 110 120 GHLLWNAGKV TSDYLDEHSK ELVEGKKVIE FGAGAGLPSL LCHAVGAKQV VITDYPDADL 130 140 150 160 170 180 LYNLKYNVDQ LKKDWDAKNA DFSGPSPCAD VSSMKVEGFI WGNDASELIE MSGGTGYDLV 190 200 210 220 230 240 ILSDVVFNHS EHAKLVRSAK ELLAPGGKVF VVFTPHRAKL FNEDLDFFRR AKDEAGFESE 250 260 270 KLFELKYYPM FEEEEETKEL RSMVFGYMLT LKE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382127 Genomic DNA. Translation: CAG83839.1.
RefSeq	XP_499912.1.
3D structure databases
SMR	Q6CHE9. Positions 60-243.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CHE9.
Genome annotation databases
GeneID	2905822.
GenomeReviews	Gene locus YALI0A09636g in contig CR382127_GR.
KEGG	yli:YALI0A09636g.
Phylogenomic databases
eggNOG	fuNOG05731.
HOGENOM	HBG397955.
OMA	VVFSPHR.
OrthoDB	EOG92BZS7.
PhylomeDB	Q6CHE9.
Enzyme and pathway databases
BRENDA	2.1.1.1. 3602.
Family and domain databases
InterPro	IPR019410. Methyltransferase-16_put. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF10294. Methyltransf_16. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NNT1_YARLI

Accession

Primary (citable) accession number: Q6CHE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)