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Q6CHD6

- PMIP_YARLI

UniProt

Q6CHD6 - PMIP_YARLI

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, YALI0A09988g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi561 – 5611Zinc; catalytic By similarity
Active sitei562 – 5621 By similarity
Metal bindingi565 – 5651Zinc; catalytic By similarity
Metal bindingi568 – 5681Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:YALI0A09988g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome A

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion Reviewed prediction
Add
BLAST
Chaini29 – 776748Mitochondrial intermediate peptidase
PRO_0000338597Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CHD6.

Structurei

3D structure databases

ProteinModelPortaliQ6CHD6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
HOGENOMiHOG000076521.
KOiK01410.
OMAiLQVFYSA.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CHD6-1 [UniParc]FASTAAdd to Basket

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MRRFSTLSRR LQRVVPASSA STANTSPSPA LYTGLEPKIK ESQDSLIRAV    50
FDNGDVWQDF SQKSVAKPKQ SRSITGFINY LTNESDYETG LFMNDFLKTP 100
AGFQKYTAAS IEEAGQLIQQ LLGALTQRDK LRHAITTFDR LSDVLCQVID 150
LAEFIRAAHP EQHFVQAAQE AHEQMYEYMN VLNTSVELYT VLDMVFKDSE 200
IVNQLTHEEK VVGTLLLEDF KKSGVTLDDA GRENFVSLTT KISLLGRDFI 250
SSNHPKEDYI TLTQGEAQGL DPQLAQQLSQ GNSVYVPTGG VPGQLALRGM 300
KNENSRKLLW SKMRESSDKS IESLEDLLVS RLELANLMGK ESYADYLLSD 350
KMAGNPENVM RFLNGLLDKT LPGAKKELSV LEQIKKQATG NPKSILQAWD 400
KSYYASQLLY QKRNKTKTAH MLSEYFSVGT VVQGLSRIFD KIYGIRFVPT 450
ETKTGETWHH DVRRLDVVSE TEGLIGIMYA DLFQREGKSP NPAHFTVRCS 500
REIYPDELAH MSSSPIAKVP TLNLNGKVFQ IPTIALICDF TTPHDLYPSL 550
LSYQEVETLF HEMGHAIHSM LGRTSLHNVC GTRCATDFVE LPSVFMENFA 600
SNPESLALFA RHYSSDSPLP YQQLERHLNE QSYFKDVEQY TQIKMAMLDQ 650
VLHGNILKSI TNGHFNSQKL YDNLEKDRPL FPPSPSSWHG SFGHLFGYGA 700
SYYCYLLDRQ MADIVWKKLF SKNPLSRDAG SRMKNEVLQW GGSRDPWECI 750
AGVLEDPELA KGGSQAMEKI GNYDKH 776
Length:776
Mass (Da):87,572
Last modified:August 16, 2004 - v1
Checksum:i60F6B023BA9AEF67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382127 Genomic DNA. Translation: CAG83853.1.
RefSeqiXP_499926.1. XM_499926.1.

Genome annotation databases

EnsemblFungiiCAG83853; CAG83853; YALI0_A09988g.
GeneIDi2905768.
KEGGiyli:YALI0A09988g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382127 Genomic DNA. Translation: CAG83853.1 .
RefSeqi XP_499926.1. XM_499926.1.

3D structure databases

ProteinModelPortali Q6CHD6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CHD6.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83853 ; CAG83853 ; YALI0_A09988g .
GeneIDi 2905768.
KEGGi yli:YALI0A09988g.

Phylogenomic databases

eggNOGi COG0339.
HOGENOMi HOG000076521.
KOi K01410.
OMAi LQVFYSA.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 1 hit.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPMIP_YARLI
AccessioniPrimary (citable) accession number: Q6CHD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi