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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi561Zinc; catalyticPROSITE-ProRule annotation1
Active sitei562PROSITE-ProRule annotation1
Metal bindingi565Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi568Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Ordered Locus Names:YALI0A09988g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000033859729 – 776Mitochondrial intermediate peptidaseAdd BLAST748

Proteomic databases

PRIDEiQ6CHD6

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_499926.1

Structurei

3D structure databases

ProteinModelPortaliQ6CHD6
SMRiQ6CHD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076521
InParanoidiQ6CHD6
KOiK01410
OMAiVENTAWQ
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CHD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFSTLSRR LQRVVPASSA STANTSPSPA LYTGLEPKIK ESQDSLIRAV
60 70 80 90 100
FDNGDVWQDF SQKSVAKPKQ SRSITGFINY LTNESDYETG LFMNDFLKTP
110 120 130 140 150
AGFQKYTAAS IEEAGQLIQQ LLGALTQRDK LRHAITTFDR LSDVLCQVID
160 170 180 190 200
LAEFIRAAHP EQHFVQAAQE AHEQMYEYMN VLNTSVELYT VLDMVFKDSE
210 220 230 240 250
IVNQLTHEEK VVGTLLLEDF KKSGVTLDDA GRENFVSLTT KISLLGRDFI
260 270 280 290 300
SSNHPKEDYI TLTQGEAQGL DPQLAQQLSQ GNSVYVPTGG VPGQLALRGM
310 320 330 340 350
KNENSRKLLW SKMRESSDKS IESLEDLLVS RLELANLMGK ESYADYLLSD
360 370 380 390 400
KMAGNPENVM RFLNGLLDKT LPGAKKELSV LEQIKKQATG NPKSILQAWD
410 420 430 440 450
KSYYASQLLY QKRNKTKTAH MLSEYFSVGT VVQGLSRIFD KIYGIRFVPT
460 470 480 490 500
ETKTGETWHH DVRRLDVVSE TEGLIGIMYA DLFQREGKSP NPAHFTVRCS
510 520 530 540 550
REIYPDELAH MSSSPIAKVP TLNLNGKVFQ IPTIALICDF TTPHDLYPSL
560 570 580 590 600
LSYQEVETLF HEMGHAIHSM LGRTSLHNVC GTRCATDFVE LPSVFMENFA
610 620 630 640 650
SNPESLALFA RHYSSDSPLP YQQLERHLNE QSYFKDVEQY TQIKMAMLDQ
660 670 680 690 700
VLHGNILKSI TNGHFNSQKL YDNLEKDRPL FPPSPSSWHG SFGHLFGYGA
710 720 730 740 750
SYYCYLLDRQ MADIVWKKLF SKNPLSRDAG SRMKNEVLQW GGSRDPWECI
760 770
AGVLEDPELA KGGSQAMEKI GNYDKH
Length:776
Mass (Da):87,572
Last modified:August 16, 2004 - v1
Checksum:i60F6B023BA9AEF67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA Translation: CAG83853.1
RefSeqiXP_499926.1, XM_499926.1

Genome annotation databases

EnsemblFungiiCAG83853; CAG83853; YALI0_A09988g
GeneIDi2905768
KEGGiyli:YALI0A09988g

Similar proteinsi

Entry informationi

Entry nameiPMIP_YARLI
AccessioniPrimary (citable) accession number: Q6CHD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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