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Q6CGG3

- FKBP2_YARLI

UniProt

Q6CGG3 - FKBP2_YARLI

Protein

FK506-binding protein 2

Gene

FPR2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited by both FK506 and rapamycin.By similarity

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FK506-binding protein 2 (EC:5.2.1.8)
    Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
    Short name:
    PPIase
    Rotamase
    Gene namesi
    Name:FPR2
    Ordered Locus Names:YALI0A19602g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome A

    Subcellular locationi

    Endoplasmic reticulum PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 144124FK506-binding protein 2PRO_0000233072Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CGG3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CGG3.
    SMRiQ6CGG3. Positions 44-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 13689PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi141 – 1444Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    KOiK09569.
    OMAiCEVQAHK.
    OrthoDBiEOG77WWQ3.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CGG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARIIVLIVA FMALIAGVFA TEEKLAKLQI GILKKISPEE CTQKARKGDT    50
    VSVHYTGKLE DGTVFDSSVE RGQPIQFPLG TGRVIPGWDQ GILGMCVGEK 100
    RKLTIPPHLA YGKQGAGRVI PPDSTLIFTT ELVSIDNDGD RDEL 144
    Length:144
    Mass (Da):15,605
    Last modified:August 16, 2004 - v1
    Checksum:iF25EF331B47F7A73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382127 Genomic DNA. Translation: CAG84187.1.
    RefSeqiXP_500249.1. XM_500249.1.

    Genome annotation databases

    EnsemblFungiiCAG84187; CAG84187; YALI0_A19602g.
    GeneIDi2906479.
    KEGGiyli:YALI0A19602g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382127 Genomic DNA. Translation: CAG84187.1 .
    RefSeqi XP_500249.1. XM_500249.1.

    3D structure databases

    ProteinModelPortali Q6CGG3.
    SMRi Q6CGG3. Positions 44-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CGG3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG84187 ; CAG84187 ; YALI0_A19602g .
    GeneIDi 2906479.
    KEGGi yli:YALI0A19602g.

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    KOi K09569.
    OMAi CEVQAHK.
    OrthoDBi EOG77WWQ3.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiFKBP2_YARLI
    AccessioniPrimary (citable) accession number: Q6CGG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3