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Q6CGG3 (FKBP2_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
FK506-binding protein 2

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:FPR2
Ordered Locus Names:YALI0A19602g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length144 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited by both FK506 and rapamycin By similarity.

Subcellular location

Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionIsomerase
Rotamase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 144124FK506-binding protein 2
PRO_0000233072

Regions

Domain48 – 13689PPIase FKBP-type
Motif141 – 1444Prevents secretion from ER Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CGG3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: F25EF331B47F7A73

FASTA14415,605
        10         20         30         40         50         60 
MARIIVLIVA FMALIAGVFA TEEKLAKLQI GILKKISPEE CTQKARKGDT VSVHYTGKLE 

        70         80         90        100        110        120 
DGTVFDSSVE RGQPIQFPLG TGRVIPGWDQ GILGMCVGEK RKLTIPPHLA YGKQGAGRVI 

       130        140 
PPDSTLIFTT ELVSIDNDGD RDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382127 Genomic DNA. Translation: CAG84187.1.
RefSeqXP_500249.1. XM_500249.1.

3D structure databases

ProteinModelPortalQ6CGG3.
SMRQ6CGG3. Positions 44-136.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CGG3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG84187; CAG84187; YALI0_A19602g.
GeneID2906479.
KEGGyli:YALI0A19602g.

Phylogenomic databases

eggNOGCOG0545.
HOGENOMHOG000154887.
KOK09569.
OMACEVQAHK.
OrthoDBEOG77WWQ3.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFKBP2_YARLI
AccessionPrimary (citable) accession number: Q6CGG3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families