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Protein

FK506-binding protein 2

Gene

FPR2

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
FK506-binding protein 2 (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:FPR2
Ordered Locus Names:YALI0A19602g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome A

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 144124FK506-binding protein 2PRO_0000233072Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6CGG3.
SMRiQ6CGG3. Positions 44-136.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 13689PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi141 – 1444Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
InParanoidiQ6CGG3.
KOiK09569.
OMAiCEVQAHK.
OrthoDBiEOG77WWQ3.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CGG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARIIVLIVA FMALIAGVFA TEEKLAKLQI GILKKISPEE CTQKARKGDT
60 70 80 90 100
VSVHYTGKLE DGTVFDSSVE RGQPIQFPLG TGRVIPGWDQ GILGMCVGEK
110 120 130 140
RKLTIPPHLA YGKQGAGRVI PPDSTLIFTT ELVSIDNDGD RDEL
Length:144
Mass (Da):15,605
Last modified:August 16, 2004 - v1
Checksum:iF25EF331B47F7A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA. Translation: CAG84187.1.
RefSeqiXP_500249.1. XM_500249.1.

Genome annotation databases

EnsemblFungiiCAG84187; CAG84187; YALI0_A19602g.
GeneIDi2906479.
KEGGiyli:YALI0A19602g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA. Translation: CAG84187.1.
RefSeqiXP_500249.1. XM_500249.1.

3D structure databases

ProteinModelPortaliQ6CGG3.
SMRiQ6CGG3. Positions 44-136.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG84187; CAG84187; YALI0_A19602g.
GeneIDi2906479.
KEGGiyli:YALI0A19602g.

Phylogenomic databases

eggNOGiCOG0545.
HOGENOMiHOG000154887.
InParanoidiQ6CGG3.
KOiK09569.
OMAiCEVQAHK.
OrthoDBiEOG77WWQ3.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_YARLI
AccessioniPrimary (citable) accession number: Q6CGG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.