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Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathwayi: D-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (ALO1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Ordered Locus Names:YALI0A21263g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001281701 – 526D-arabinono-1,4-lactone oxidaseAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Pros-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiQ6CG88

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_500324.1

Structurei

3D structure databases

ProteinModelPortaliQ6CG88
SMRiQ6CG88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 196FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST175

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204635
InParanoidiQ6CG88
KOiK00107
OMAiFRFLWFP
OrthoDBiEOG092C14O7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
InterProiView protein in InterPro
IPR007173 ALO
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR010031 FAD_lactone_oxidase
IPR006094 Oxid_FAD_bind_N
IPR030654 Sugar_lactone_oxidase
PANTHERiPTHR43762 PTHR43762, 1 hit
PfamiView protein in Pfam
PF04030 ALO, 1 hit
PF01565 FAD_binding_4, 1 hit
PIRSFiPIRSF000136 LGO_GLO, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
TIGRFAMsiTIGR01678 FAD_lactone_ox, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CG88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRNSTTAK RFHSHKTWAG TFWSRPSLYF QPASIEELQA IVTRARDLGK
60 70 80 90 100
TIMVVGSAHS PSDLTMTSQW LVNLDKLSKA VSFKPHTSGL YTDVTVEAGI
110 120 130 140 150
RIHQLNEVLK RKGLAMQNLG SISDQSVAGI ISTGTHGSSA YHGLVSQQIV
160 170 180 190 200
SLTIMIASGE LLTCSPDENP TLFRAALLSL GKLGIIVYAT LRTVPAYTIH
210 220 230 240 250
STQHVITFET LIREWDNLWT ASEYIRVWWF PYAERCILWR ASKSELPLSA
260 270 280 290 300
PRPSWYGTWL GRLFYETLLW VSVRLWPSLT PSVERFIFSR QYGMEDTLGS
310 320 330 340 350
GTGSEAVQGS VEGLNMDCLF SQFVNEWGMP LDNGPDVLRA LRAKIEAAAK
360 370 380 390 400
DNIYYVHSPV EVRCSNMSVP DSGDRNVEPN TQEFSASRRG AITGNTLRPL
410 420 430 440 450
LDINPRDRPY ASPHGHVTNS NLTLYINATM YRPFGVNSPV GKWYRDFEGI
460 470 480 490 500
VAEAGGKPHW AKNFLGPETA ELKDNESEDG KMLGLKPIID EWYGDDLKQW
510 520
KSLREKYDPT GVFLSGKVWM DRNGLL
Length:526
Mass (Da):58,900
Last modified:August 16, 2004 - v1
Checksum:i19AC25D2944948A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA Translation: CAG84262.1
RefSeqiXP_500324.1, XM_500324.1

Genome annotation databases

EnsemblFungiiCAG84262; CAG84262; YALI0_A21263g
GeneIDi2906352
KEGGiyli:YALI0A21263g

Similar proteinsi

Entry informationi

Entry nameiALO_YARLI
AccessioniPrimary (citable) accession number: Q6CG88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health