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Protein

D-arabinono-1,4-lactone oxidase

Gene

ALO1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2.

Cofactori

FADBy similarity

Pathway:iD-erythroascorbate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. D-arabinono-1,4-lactone oxidase (ALO1)
This subpathway is part of the pathway D-erythroascorbate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dehydro-D-arabinono-1,4-lactone from D-arabinose, the pathway D-erythroascorbate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Names & Taxonomyi

Protein namesi
Recommended name:
D-arabinono-1,4-lactone oxidase (EC:1.1.3.37)
Short name:
ALO
Alternative name(s):
L-galactono-gamma-lactone oxidase
Gene namesi
Name:ALO1
Ordered Locus Names:YALI0A21263g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome A

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526D-arabinono-1,4-lactone oxidasePRO_0000128170Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Pros-8alpha-FAD histidineBy similarity

Structurei

3D structure databases

ProteinModelPortaliQ6CG88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 196175FAD-binding PCMH-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000204635.
InParanoidiQ6CG88.
KOiK00107.
OMAiNMDCLFS.
OrthoDBiEOG7JX3CZ.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR030654. Sugar_lactone_oxidase.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CG88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRNSTTAK RFHSHKTWAG TFWSRPSLYF QPASIEELQA IVTRARDLGK
60 70 80 90 100
TIMVVGSAHS PSDLTMTSQW LVNLDKLSKA VSFKPHTSGL YTDVTVEAGI
110 120 130 140 150
RIHQLNEVLK RKGLAMQNLG SISDQSVAGI ISTGTHGSSA YHGLVSQQIV
160 170 180 190 200
SLTIMIASGE LLTCSPDENP TLFRAALLSL GKLGIIVYAT LRTVPAYTIH
210 220 230 240 250
STQHVITFET LIREWDNLWT ASEYIRVWWF PYAERCILWR ASKSELPLSA
260 270 280 290 300
PRPSWYGTWL GRLFYETLLW VSVRLWPSLT PSVERFIFSR QYGMEDTLGS
310 320 330 340 350
GTGSEAVQGS VEGLNMDCLF SQFVNEWGMP LDNGPDVLRA LRAKIEAAAK
360 370 380 390 400
DNIYYVHSPV EVRCSNMSVP DSGDRNVEPN TQEFSASRRG AITGNTLRPL
410 420 430 440 450
LDINPRDRPY ASPHGHVTNS NLTLYINATM YRPFGVNSPV GKWYRDFEGI
460 470 480 490 500
VAEAGGKPHW AKNFLGPETA ELKDNESEDG KMLGLKPIID EWYGDDLKQW
510 520
KSLREKYDPT GVFLSGKVWM DRNGLL
Length:526
Mass (Da):58,900
Last modified:August 16, 2004 - v1
Checksum:i19AC25D2944948A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA. Translation: CAG84262.1.
RefSeqiXP_500324.1. XM_500324.1.

Genome annotation databases

EnsemblFungiiCAG84262; CAG84262; YALI0_A21263g.
GeneIDi2906352.
KEGGiyli:YALI0A21263g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382127 Genomic DNA. Translation: CAG84262.1.
RefSeqiXP_500324.1. XM_500324.1.

3D structure databases

ProteinModelPortaliQ6CG88.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG84262; CAG84262; YALI0_A21263g.
GeneIDi2906352.
KEGGiyli:YALI0A21263g.

Phylogenomic databases

eggNOGiCOG0277.
HOGENOMiHOG000204635.
InParanoidiQ6CG88.
KOiK00107.
OMAiNMDCLFS.
OrthoDBiEOG7JX3CZ.

Enzyme and pathway databases

UniPathwayiUPA00771; UER00766.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR007173. ALO.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR010031. FAD_lactone_oxidase.
IPR006094. Oxid_FAD_bind_N.
IPR030654. Sugar_lactone_oxidase.
[Graphical view]
PfamiPF04030. ALO. 1 hit.
PF01565. FAD_binding_4. 1 hit.
[Graphical view]
PIRSFiPIRSF000136. LGO_GLO. 1 hit.
SUPFAMiSSF56176. SSF56176. 1 hit.
TIGRFAMsiTIGR01678. FAD_lactone_ox. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALO_YARLI
AccessioniPrimary (citable) accession number: Q6CG88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: August 16, 2004
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.