Q6CG02 (MED8_YARLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 8

Alternative name(s):
Mediator complex subunit 8

Gene names

Name:	MED8
Ordered Locus Names:	YALI0B02068g

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Taxonomic identifier

284591 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.
Subunit structure	Component of the Mediator complex By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Mediator complex subunit 8 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mediator complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA polymerase II transcription cofactor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Mediator of RNA polymerase II transcription subunit 8		PRO_0000304547

Sequences

	Sequence		Length	Mass (Da)
	Q6CG02 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A673F3F5B219647B	FASTA	194	21,744
	10 20 30 40 50 60 MNQPIEPDHI NVPTEALESL RLRLTQVSHS LNTLQAQLHQ PTLPPWSSLH NQFNVLLTQL 70 80 90 100 110 120 VSLSSTITHQ SDILQQTVTF PLPAFPTATE AGLMATLLRK KILPEVEEWC EEVKQKALGV 130 140 150 160 170 180 KIRTVDQYGE WAAETVEEAK QEYEWYGLMT REEVDNGVKP PVYVAPEEEA GEGAKLTIEQ 190 ILQFTCAGKM PTVA

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382128 Genomic DNA. Translation: CAG82628.1.
RefSeq	XP_500410.1. XM_500410.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CG02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2907557.
GenomeReviews	Gene locus YALI0B02068g in contig CR382128_GR.
KEGG	yli:YALI0B02068g.
Phylogenomic databases
eggNOG	fuNOG10124.
OMA	QNQFQVL.
OrthoDB	EOG4FFHBC.
Family and domain databases
InterPro	IPR020178. Mediatior_Med8_fun. IPR019364. Mediatior_Med8_fun/met. [Graphical view]
KO	K15130.
Pfam	PF10232. Med8. 1 hit. [Graphical view]
ProDom	PD114219. Mediatior_Med8_fun. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

MED8_YARLI

Accession

Primary (citable) accession number: Q6CG02

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program