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Q6CFX1

- 3HAO_YARLI

UniProt

Q6CFX1 - 3HAO_YARLI

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441DioxygenUniRule annotation
Metal bindingi48 – 481Iron; catalyticUniRule annotation
Metal bindingi54 – 541Iron; catalyticUniRule annotation
Binding sitei54 – 541SubstrateUniRule annotation
Metal bindingi92 – 921Iron; catalyticUniRule annotation
Binding sitei96 – 961SubstrateUniRule annotation
Binding sitei106 – 1061SubstrateUniRule annotation
Metal bindingi121 – 1211Divalent metal cationUniRule annotation
Metal bindingi126 – 1261Divalent metal cationUniRule annotation
Metal bindingi160 – 1601Divalent metal cationUniRule annotation
Metal bindingi163 – 1631Divalent metal cationUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Biosynthesis of nicotinic acid protein 1UniRule annotation
Gene namesi
Name:BNA1UniRule annotation
Ordered Locus Names:YALI0B02852g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1711713-hydroxyanthranilate 3,4-dioxygenasePRO_0000361996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CFX1.

Structurei

3D structure databases

ProteinModelPortaliQ6CFX1.
SMRiQ6CFX1. Positions 5-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
InParanoidiQ6CFX1.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CFX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQEPINLPK WLEENQHLLK PPVNNFCIQR GGYTVMIVGG PNARTDYHIN
60 70 80 90 100
QTPEWFHQKK GHMTLKVVDD GEFRDITINE GDIFLLPANV PHNPVRYADT
110 120 130 140 150
IGVVVEQDRP EGMKDALRWY CPNEKCREIV FENSFQLVDL GTQIKEAILD
160 170
FDGDIEKRTC KACGTVATSR P
Length:171
Mass (Da):19,550
Last modified:August 16, 2004 - v1
Checksum:iB181F188D026A2AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82659.1.
RefSeqiXP_500441.1. XM_500441.1.

Genome annotation databases

EnsemblFungiiCAG82659; CAG82659; YALI0_B02852g.
GeneIDi2907509.
KEGGiyli:YALI0B02852g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82659.1 .
RefSeqi XP_500441.1. XM_500441.1.

3D structure databases

ProteinModelPortali Q6CFX1.
SMRi Q6CFX1. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CFX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82659 ; CAG82659 ; YALI0_B02852g .
GeneIDi 2907509.
KEGGi yli:YALI0B02852g.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
InParanoidi Q6CFX1.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Entry informationi

Entry namei3HAO_YARLI
AccessioniPrimary (citable) accession number: Q6CFX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3