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Q6CFX1

- 3HAO_YARLI

UniProt

Q6CFX1 - 3HAO_YARLI

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

BNA1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441DioxygenUniRule annotation
    Metal bindingi48 – 481Iron; catalyticUniRule annotation
    Metal bindingi54 – 541Iron; catalyticUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Metal bindingi92 – 921Iron; catalyticUniRule annotation
    Binding sitei96 – 961SubstrateUniRule annotation
    Binding sitei106 – 1061SubstrateUniRule annotation
    Metal bindingi121 – 1211Divalent metal cationUniRule annotation
    Metal bindingi126 – 1261Divalent metal cationUniRule annotation
    Metal bindingi160 – 1601Divalent metal cationUniRule annotation
    Metal bindingi163 – 1631Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Biosynthesis of nicotinic acid protein 1UniRule annotation
    Gene namesi
    Name:BNA1UniRule annotation
    Ordered Locus Names:YALI0B02852g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome B

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1711713-hydroxyanthranilate 3,4-dioxygenasePRO_0000361996Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CFX1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CFX1.
    SMRiQ6CFX1. Positions 5-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG77058.
    HOGENOMiHOG000218448.
    KOiK00452.
    OMAiHINQTPE.
    OrthoDBiEOG7QK0Q0.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6CFX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQEPINLPK WLEENQHLLK PPVNNFCIQR GGYTVMIVGG PNARTDYHIN    50
    QTPEWFHQKK GHMTLKVVDD GEFRDITINE GDIFLLPANV PHNPVRYADT 100
    IGVVVEQDRP EGMKDALRWY CPNEKCREIV FENSFQLVDL GTQIKEAILD 150
    FDGDIEKRTC KACGTVATSR P 171
    Length:171
    Mass (Da):19,550
    Last modified:August 16, 2004 - v1
    Checksum:iB181F188D026A2AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82659.1.
    RefSeqiXP_500441.1. XM_500441.1.

    Genome annotation databases

    EnsemblFungiiCAG82659; CAG82659; YALI0_B02852g.
    GeneIDi2907509.
    KEGGiyli:YALI0B02852g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82659.1 .
    RefSeqi XP_500441.1. XM_500441.1.

    3D structure databases

    ProteinModelPortali Q6CFX1.
    SMRi Q6CFX1. Positions 5-171.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CFX1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82659 ; CAG82659 ; YALI0_B02852g .
    GeneIDi 2907509.
    KEGGi yli:YALI0B02852g.

    Phylogenomic databases

    eggNOGi NOG77058.
    HOGENOMi HOG000218448.
    KOi K00452.
    OMAi HINQTPE.
    OrthoDBi EOG7QK0Q0.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry namei3HAO_YARLI
    AccessioniPrimary (citable) accession number: Q6CFX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3