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Q6CFX1

- 3HAO_YARLI

UniProt

Q6CFX1 - 3HAO_YARLI

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene
BNA1, YALI0B02852g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Dioxygen By similarity
Metal bindingi48 – 481Iron; catalytic By similarity
Metal bindingi54 – 541Iron; catalytic By similarity
Binding sitei54 – 541Substrate By similarity
Metal bindingi92 – 921Iron; catalytic By similarity
Binding sitei96 – 961Substrate By similarity
Binding sitei106 – 1061Substrate By similarity
Metal bindingi121 – 1211Divalent metal cation By similarity
Metal bindingi126 – 1261Divalent metal cation By similarity
Metal bindingi160 – 1601Divalent metal cation By similarity
Metal bindingi163 – 1631Divalent metal cation By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Biosynthesis of nicotinic acid protein 1
Gene namesi
Name:BNA1
Ordered Locus Names:YALI0B02852g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1711713-hydroxyanthranilate 3,4-dioxygenaseUniRule annotationPRO_0000361996Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CFX1.

Structurei

3D structure databases

ProteinModelPortaliQ6CFX1.
SMRiQ6CFX1. Positions 5-171.

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

eggNOGiNOG77058.
HOGENOMiHOG000218448.
KOiK00452.
OMAiHINQTPE.
OrthoDBiEOG7QK0Q0.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CFX1-1 [UniParc]FASTAAdd to Basket

« Hide

MLQEPINLPK WLEENQHLLK PPVNNFCIQR GGYTVMIVGG PNARTDYHIN    50
QTPEWFHQKK GHMTLKVVDD GEFRDITINE GDIFLLPANV PHNPVRYADT 100
IGVVVEQDRP EGMKDALRWY CPNEKCREIV FENSFQLVDL GTQIKEAILD 150
FDGDIEKRTC KACGTVATSR P 171
Length:171
Mass (Da):19,550
Last modified:August 16, 2004 - v1
Checksum:iB181F188D026A2AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG82659.1.
RefSeqiXP_500441.1. XM_500441.1.

Genome annotation databases

EnsemblFungiiCAG82659; CAG82659; YALI0_B02852g.
GeneIDi2907509.
KEGGiyli:YALI0B02852g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG82659.1 .
RefSeqi XP_500441.1. XM_500441.1.

3D structure databases

ProteinModelPortali Q6CFX1.
SMRi Q6CFX1. Positions 5-171.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CFX1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82659 ; CAG82659 ; YALI0_B02852g .
GeneIDi 2907509.
KEGGi yli:YALI0B02852g.

Phylogenomic databases

eggNOGi NOG77058.
HOGENOMi HOG000218448.
KOi K00452.
OMAi HINQTPE.
OrthoDBi EOG7QK0Q0.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Entry informationi

Entry namei3HAO_YARLI
AccessioniPrimary (citable) accession number: Q6CFX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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