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Q6CFX1 (3HAO_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Biosynthesis of nicotinic acid protein 1
Gene names
Name:BNA1
Ordered Locus Names:YALI0B02852g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia ›

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the 3-HAO family.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-hydroxyanthranilate 3,4-dioxygenase activity

Inferred from electronic annotation. Source: EC

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 1711713-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000361996

Sites

Metal binding481Iron; catalytic By similarity
Metal binding541Iron; catalytic By similarity
Metal binding921Iron; catalytic By similarity
Metal binding1211Divalent metal cation By similarity
Metal binding1261Divalent metal cation By similarity
Metal binding1601Divalent metal cation By similarity
Metal binding1631Divalent metal cation By similarity
Binding site441Dioxygen By similarity
Binding site541Substrate By similarity
Binding site961Substrate By similarity
Binding site1061Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CFX1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B181F188D026A2AD

FASTA17119,550
        10         20         30         40         50         60 
MLQEPINLPK WLEENQHLLK PPVNNFCIQR GGYTVMIVGG PNARTDYHIN QTPEWFHQKK 

        70         80         90        100        110        120 
GHMTLKVVDD GEFRDITINE GDIFLLPANV PHNPVRYADT IGVVVEQDRP EGMKDALRWY 

       130        140        150        160        170 
CPNEKCREIV FENSFQLVDL GTQIKEAILD FDGDIEKRTC KACGTVATSR P

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382128 Genomic DNA. Translation: CAG82659.1.
RefSeqXP_500441.1. XM_500441.1.

3D structure databases

HSSPHSSP built from PDB template 1ZVF based on UniProtKB P47096.
ProteinModelPortalQ6CFX1.
SMRQ6CFX1. Positions 5-171.
ModBaseSearch...

Protein-protein interaction databases

STRING4952.Q6CFX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2907509.
KEGGyli:YALI0B02852g.

Phylogenomic databases

eggNOGNOG77058.
HOGENOMHOG000218448.
KOK00452.
OMAHSPQRPE.
OrthoDBEOG476P8N.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_YARLI
AccessionPrimary (citable) accession number: Q6CFX1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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