Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6CFP3 (KEX1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
Ordered Locus Names:YALI0B05170g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length614 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 614597Pheromone-processing carboxypeptidase KEX1
PRO_0000411953

Regions

Topological domain18 – 518501Lumenal Potential
Transmembrane519 – 53921Helical; Potential
Topological domain540 – 61475Cytoplasmic Potential
Compositional bias478 – 50427Asp-rich

Sites

Active site1771 By similarity
Active site3791 By similarity
Active site4371 By similarity

Amino acid modifications

Glycosylation421N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential
Glycosylation4341N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6CFP3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1E9B44FB4EA02442

FASTA61469,331
        10         20         30         40         50         60 
MKLSWSLFCG LASLALSQFD EAPPSQSDYF VRHIPGLDSV DNYTMHSGNI LTDAAHNGNL 

        70         80         90        100        110        120 
FFWLVEAQYK ITERPKTIVW FNGGPGCSSM DGALLEVGPF RIVDDKLRVD PNKGSWHKYA 

       130        140        150        160        170        180 
NVLFVDQPYG TGYSYSDTDS YLTGLGQVGD EMDSFMTQFL KLFPERAHDD FYLAGESYAG 

       190        200        210        220        230        240 
QYIPYIATKL QQTRTVDLKG LLIGNGWMDP ANQYYQYVPY ALDYGVIEKT EEHVKDLKEL 

       250        260        270        280        290        300 
TDTCERAINI AKDKNNGRLP VHIRACEDIM NGIVELSRNE RSAPESEGIC VNYYDVSKED 

       310        320        330        340        350        360 
KWPSCGMNWP EILPYVTDWL RQDATVQALN VNNDKQESWQ ECNGAVGSRM RQGNDDAAVY 

       370        380        390        400        410        420 
LLPDLLESME ILFFNGDRDL ICNHYGNERM IEQLEWNGKK GWTEGLELDD WVVDGVSKGK 

       430        440        450        460        470        480 
KQSDRNLTYV RIYNASHMVP YDEPEACLTM LNDFIGVSKA LSDLSGNKPG RGSENPSDLD 

       490        500        510        520        530        540 
DQKSGDQKSD DDSSSDDDDD AEHDKKIASD AMWKAYYQAG FTALIVVLII LGLAGFLFWR 

       550        560        570        580        590        600 
KNRGHIYQEE TSLLGSCFGG ISRWRNSSGG PLSNQQGTFD SRQRLMEPGE YYDLGEIAEE 

       610 
DEDAEELVIR RPEV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382128 Genomic DNA. Translation: CAG82750.1.
RefSeqXP_500519.1. XM_500519.1.

3D structure databases

ProteinModelPortalQ6CFP3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CFP3.

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82750; CAG82750; YALI0_B05170g.
GeneID2906626.
KEGGyli:YALI0B05170g.

Phylogenomic databases

HOGENOMHOG000208879.
KOK01288.
OMAMATHPTH.
OrthoDBEOG7TJ3SJ.

Family and domain databases

InterProIPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
PROSITEPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_YARLI
AccessionPrimary (citable) accession number: Q6CFP3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 16, 2004
Last modified: March 19, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries