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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei177By similarity1
Active sitei379By similarity1
Active sitei437By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERiyarli-q6cfp3 Carboxypeptidase_S10
MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:YALI0B05170g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 518LumenalSequence analysisAdd BLAST501
Transmembranei519 – 539HelicalSequence analysisAdd BLAST21
Topological domaini540 – 614CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000041195318 – 614Pheromone-processing carboxypeptidase KEX1Add BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi434N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6CFP3

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_500519.1

Structurei

3D structure databases

ProteinModelPortaliQ6CFP3
SMRiQ6CFP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi478 – 504Asp-richAdd BLAST27

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879
InParanoidiQ6CFP3
KOiK01288
OMAiMLDRFMG
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR033124 Ser_caboxypep_his_AS
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00560 CARBOXYPEPT_SER_HIS, 1 hit
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CFP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSWSLFCG LASLALSQFD EAPPSQSDYF VRHIPGLDSV DNYTMHSGNI
60 70 80 90 100
LTDAAHNGNL FFWLVEAQYK ITERPKTIVW FNGGPGCSSM DGALLEVGPF
110 120 130 140 150
RIVDDKLRVD PNKGSWHKYA NVLFVDQPYG TGYSYSDTDS YLTGLGQVGD
160 170 180 190 200
EMDSFMTQFL KLFPERAHDD FYLAGESYAG QYIPYIATKL QQTRTVDLKG
210 220 230 240 250
LLIGNGWMDP ANQYYQYVPY ALDYGVIEKT EEHVKDLKEL TDTCERAINI
260 270 280 290 300
AKDKNNGRLP VHIRACEDIM NGIVELSRNE RSAPESEGIC VNYYDVSKED
310 320 330 340 350
KWPSCGMNWP EILPYVTDWL RQDATVQALN VNNDKQESWQ ECNGAVGSRM
360 370 380 390 400
RQGNDDAAVY LLPDLLESME ILFFNGDRDL ICNHYGNERM IEQLEWNGKK
410 420 430 440 450
GWTEGLELDD WVVDGVSKGK KQSDRNLTYV RIYNASHMVP YDEPEACLTM
460 470 480 490 500
LNDFIGVSKA LSDLSGNKPG RGSENPSDLD DQKSGDQKSD DDSSSDDDDD
510 520 530 540 550
AEHDKKIASD AMWKAYYQAG FTALIVVLII LGLAGFLFWR KNRGHIYQEE
560 570 580 590 600
TSLLGSCFGG ISRWRNSSGG PLSNQQGTFD SRQRLMEPGE YYDLGEIAEE
610
DEDAEELVIR RPEV
Length:614
Mass (Da):69,331
Last modified:August 16, 2004 - v1
Checksum:i1E9B44FB4EA02442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA Translation: CAG82750.1
RefSeqiXP_500519.1, XM_500519.1

Genome annotation databases

EnsemblFungiiCAG82750; CAG82750; YALI0_B05170g
GeneIDi2906626
KEGGiyli:YALI0B05170g

Similar proteinsi

Entry informationi

Entry nameiKEX1_YARLI
AccessioniPrimary (citable) accession number: Q6CFP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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