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Q6CFP3

- KEX1_YARLI

UniProt

Q6CFP3 - KEX1_YARLI

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771By similarity
    Active sitei379 – 3791By similarity
    Active sitei437 – 4371By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiS10.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    Ordered Locus Names:YALI0B05170g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome B

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 614597Pheromone-processing carboxypeptidase KEX1PRO_0000411953Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CFP3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CFP3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 518501LumenalSequence AnalysisAdd
    BLAST
    Topological domaini540 – 61475CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei519 – 53921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi478 – 50427Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000208879.
    KOiK01288.
    OMAiCERAINI.
    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CFP3-1 [UniParc]FASTAAdd to Basket

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    MKLSWSLFCG LASLALSQFD EAPPSQSDYF VRHIPGLDSV DNYTMHSGNI    50
    LTDAAHNGNL FFWLVEAQYK ITERPKTIVW FNGGPGCSSM DGALLEVGPF 100
    RIVDDKLRVD PNKGSWHKYA NVLFVDQPYG TGYSYSDTDS YLTGLGQVGD 150
    EMDSFMTQFL KLFPERAHDD FYLAGESYAG QYIPYIATKL QQTRTVDLKG 200
    LLIGNGWMDP ANQYYQYVPY ALDYGVIEKT EEHVKDLKEL TDTCERAINI 250
    AKDKNNGRLP VHIRACEDIM NGIVELSRNE RSAPESEGIC VNYYDVSKED 300
    KWPSCGMNWP EILPYVTDWL RQDATVQALN VNNDKQESWQ ECNGAVGSRM 350
    RQGNDDAAVY LLPDLLESME ILFFNGDRDL ICNHYGNERM IEQLEWNGKK 400
    GWTEGLELDD WVVDGVSKGK KQSDRNLTYV RIYNASHMVP YDEPEACLTM 450
    LNDFIGVSKA LSDLSGNKPG RGSENPSDLD DQKSGDQKSD DDSSSDDDDD 500
    AEHDKKIASD AMWKAYYQAG FTALIVVLII LGLAGFLFWR KNRGHIYQEE 550
    TSLLGSCFGG ISRWRNSSGG PLSNQQGTFD SRQRLMEPGE YYDLGEIAEE 600
    DEDAEELVIR RPEV 614
    Length:614
    Mass (Da):69,331
    Last modified:August 16, 2004 - v1
    Checksum:i1E9B44FB4EA02442
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82750.1.
    RefSeqiXP_500519.1. XM_500519.1.

    Genome annotation databases

    EnsemblFungiiCAG82750; CAG82750; YALI0_B05170g.
    GeneIDi2906626.
    KEGGiyli:YALI0B05170g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82750.1 .
    RefSeqi XP_500519.1. XM_500519.1.

    3D structure databases

    ProteinModelPortali Q6CFP3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CFP3.

    Protein family/group databases

    MEROPSi S10.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82750 ; CAG82750 ; YALI0_B05170g .
    GeneIDi 2906626.
    KEGGi yli:YALI0B05170g.

    Phylogenomic databases

    HOGENOMi HOG000208879.
    KOi K01288.
    OMAi CERAINI.
    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
    PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiKEX1_YARLI
    AccessioniPrimary (citable) accession number: Q6CFP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3