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Q6CFP3

- KEX1_YARLI

UniProt

Q6CFP3 - KEX1_YARLI

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771By similarity
Active sitei379 – 3791By similarity
Active sitei437 – 4371By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:YALI0B05170g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 518501LumenalSequence AnalysisAdd
BLAST
Transmembranei519 – 53921HelicalSequence AnalysisAdd
BLAST
Topological domaini540 – 61475CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 614597Pheromone-processing carboxypeptidase KEX1PRO_0000411953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi42 – 421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi434 – 4341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CFP3.

Structurei

3D structure databases

ProteinModelPortaliQ6CFP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi478 – 50427Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000208879.
InParanoidiQ6CFP3.
KOiK01288.
OMAiCERAINI.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CFP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSWSLFCG LASLALSQFD EAPPSQSDYF VRHIPGLDSV DNYTMHSGNI
60 70 80 90 100
LTDAAHNGNL FFWLVEAQYK ITERPKTIVW FNGGPGCSSM DGALLEVGPF
110 120 130 140 150
RIVDDKLRVD PNKGSWHKYA NVLFVDQPYG TGYSYSDTDS YLTGLGQVGD
160 170 180 190 200
EMDSFMTQFL KLFPERAHDD FYLAGESYAG QYIPYIATKL QQTRTVDLKG
210 220 230 240 250
LLIGNGWMDP ANQYYQYVPY ALDYGVIEKT EEHVKDLKEL TDTCERAINI
260 270 280 290 300
AKDKNNGRLP VHIRACEDIM NGIVELSRNE RSAPESEGIC VNYYDVSKED
310 320 330 340 350
KWPSCGMNWP EILPYVTDWL RQDATVQALN VNNDKQESWQ ECNGAVGSRM
360 370 380 390 400
RQGNDDAAVY LLPDLLESME ILFFNGDRDL ICNHYGNERM IEQLEWNGKK
410 420 430 440 450
GWTEGLELDD WVVDGVSKGK KQSDRNLTYV RIYNASHMVP YDEPEACLTM
460 470 480 490 500
LNDFIGVSKA LSDLSGNKPG RGSENPSDLD DQKSGDQKSD DDSSSDDDDD
510 520 530 540 550
AEHDKKIASD AMWKAYYQAG FTALIVVLII LGLAGFLFWR KNRGHIYQEE
560 570 580 590 600
TSLLGSCFGG ISRWRNSSGG PLSNQQGTFD SRQRLMEPGE YYDLGEIAEE
610
DEDAEELVIR RPEV
Length:614
Mass (Da):69,331
Last modified:August 16, 2004 - v1
Checksum:i1E9B44FB4EA02442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82750.1.
RefSeqiXP_500519.1. XM_500519.1.

Genome annotation databases

EnsemblFungiiCAG82750; CAG82750; YALI0_B05170g.
GeneIDi2906626.
KEGGiyli:YALI0B05170g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82750.1 .
RefSeqi XP_500519.1. XM_500519.1.

3D structure databases

ProteinModelPortali Q6CFP3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CFP3.

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82750 ; CAG82750 ; YALI0_B05170g .
GeneIDi 2906626.
KEGGi yli:YALI0B05170g.

Phylogenomic databases

HOGENOMi HOG000208879.
InParanoidi Q6CFP3.
KOi K01288.
OMAi CERAINI.
OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKEX1_YARLI
AccessioniPrimary (citable) accession number: Q6CFP3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3