SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6CF18

- NTE1_YARLI

UniProt

Q6CF18 - NTE1_YARLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lysophospholipase NTE1

Gene
NTE1, YALI0B11044g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1157 – 11571 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi615 – 735121cNMP 1Add
BLAST
Nucleotide bindingi731 – 870140cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:YALI0B11044g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060Cytoplasmic By similarityAdd
BLAST
Transmembranei61 – 8121Helical; Reviewed predictionAdd
BLAST
Topological domaini82 – 9615Lumenal By similarityAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Topological domaini118 – 14271310Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14271427Lysophospholipase NTE1PRO_0000295332Add
BLAST

Proteomic databases

PRIDEiQ6CF18.

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CF18.

Structurei

3D structure databases

ProteinModelPortaliQ6CF18.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1124 – 1288165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1155 – 11595GXSXG

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CF18-1 [UniParc]FASTAAdd to Basket

« Hide

MDSLHVSSTS VLVDVVEAVE TATSLVVDTA EAVATEQATP TAVISNALAR     50
SAYAAHTSLS YLAWAFGLWF LRLIGWVCYG IPTYVLGLLG RTINISLQFS 100
SLLLILIALV TVVVAVVRYK YLTVYSRLPQ EQPRQEPEID MYDESDNEDE 150
KTGFANYFDE FLSAVKIFGY LERPVFHELT RHMQTWKLSA DEMVPLDDEQ 200
GFSVVVEGTV QVFAKQSSFV QNPTSVPDSR KEDSIMFNGE RYTLLSEIKN 250
GAPLTSLFNI LSLFTDDLQL HKNFDSAVNS PMTSASDVPN MSLSSDGSDD 300
LQKGEPQFGE PRLSEKPAAK LSVTVRAATD STIAIIPAAA FRRITKKFPQ 350
ATAHIVQVIL TRFQRVTFQT GHHYFGLTPE IFQTEVNLNS HARNELPGYL 400
REGAVKKLNQ VYDASQMGGR PKKYTVTLNK KNKGKGSRRQ RFSVQLNNQG 450
HLNSQSRMVS LDSLEAVGDH MNPGDLLTNV PLSRQGRPVF ELSSVKHKAS 500
IQNLSFSGND DENEDTALRT ALVEAIFKVL GIDRDSIQSS IMAVKTMSNT 550
ASPMFTGATT GGSSGSLGEE LRSRRTGQDS LGASHFGVGL PSERSQNSFY 600
ARSETSTSSV DEDSLMAAPF DTIRNDVAQY MDVVLFKKDS LLIKQDDPTP 650
GLYYLIDGVL EVGYTDHHKI YHDLYTVQPG GVGGYIGSIL GHRSFADLRA 700
RTDVYAGFLP RAAIERMSDK YPMVHLTMAK SLTKVLSRLL LHLDFAMEWV 750
QVRAGQKIYK EGQEADAIYI VLNGRVRSVA ETKGDSGIVG GESGDAKDGK 800
SHRKNLTSIG EYGKGESVGE LEVLTLTRRP STLVAIRDAE LAKIPRALFE 850
SLALHYPSIT FEISRIVASR VRTLMEDSAP IPRRMHTFDM AAHHDSYLTI 900
AVVPISQDVD VSEFGRRLYN GMQAVGREAC HLNHASVLNH MGRHAFNPLG 950
KLKLSGFLDD IEDRYQTVLY VADTPPGSSW THTCISQADC VLLVADARSE 1000
PDIGEYERVL VKMRTTARTE MVLIHPERYV PPGLTSAWLK PRVWVHTHHH 1050
VQMDLPRHEA DVLASIRKMK RTGTLANLKN KVQTIQEEFR SMYRPKANIY 1100
STSSANKDDF NRLARILSGQ AIGLVLGGGG ARGISHIGII KALEDSGIPI 1150
DFVGGTSIGS FIGGLYAKEY DLVPIYGRAK KFSGRVSSLW RMALDLTYPA 1200
TSYTTGHEFN RGIWKAFGDS RIEDFWLRYF TNTTNITHSR MEIHTSGYAW 1250
RYIRASMSLA GLLPPLTDNG SMLLDGGYVD NLPVSEMKAQ GASVVFAVDV 1300
GSIDDTTPMN YGDSLSGAWV MWNRWNPFGR HPNVPNLAEI QARLAYVSSV 1350
GALEKAKHTP GVIYMRPPID DFATLDFAKF LDIYRVGNKY GHKFLTELRE 1400
DGKFPAIPGM ENVKTKHKRT IARRNSI 1427
Length:1,427
Mass (Da):158,153
Last modified:August 16, 2004 - v1
Checksum:i7A0F25C6577907B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG82990.1.
RefSeqiXP_500744.1. XM_500744.1.

Genome annotation databases

EnsemblFungiiCAG82990; CAG82990; YALI0_B11044g.
GeneIDi2906874.
KEGGiyli:YALI0B11044g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG82990.1 .
RefSeqi XP_500744.1. XM_500744.1.

3D structure databases

ProteinModelPortali Q6CF18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CF18.

Proteomic databases

PRIDEi Q6CF18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82990 ; CAG82990 ; YALI0_B11044g .
GeneIDi 2906874.
KEGGi yli:YALI0B11044g.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000048680.
KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 4 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiNTE1_YARLI
AccessioniPrimary (citable) accession number: Q6CF18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3