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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1157 – 11571By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi615 – 735121cNMP 1Add
BLAST
Nucleotide bindingi731 – 870140cNMP 2Add
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:YALI0B11044g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300 Componenti: Chromosome B

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6060CytoplasmicBy similarityAdd
BLAST
Transmembranei61 – 8121HelicalSequence AnalysisAdd
BLAST
Topological domaini82 – 9615LumenalBy similarityAdd
BLAST
Transmembranei97 – 11721HelicalSequence AnalysisAdd
BLAST
Topological domaini118 – 14271310CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14271427Lysophospholipase NTE1PRO_0000295332Add
BLAST

Proteomic databases

PRIDEiQ6CF18.

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_500744.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CF18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1124 – 1288165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1155 – 11595GXSXG

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ6CF18.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CF18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLHVSSTS VLVDVVEAVE TATSLVVDTA EAVATEQATP TAVISNALAR
60 70 80 90 100
SAYAAHTSLS YLAWAFGLWF LRLIGWVCYG IPTYVLGLLG RTINISLQFS
110 120 130 140 150
SLLLILIALV TVVVAVVRYK YLTVYSRLPQ EQPRQEPEID MYDESDNEDE
160 170 180 190 200
KTGFANYFDE FLSAVKIFGY LERPVFHELT RHMQTWKLSA DEMVPLDDEQ
210 220 230 240 250
GFSVVVEGTV QVFAKQSSFV QNPTSVPDSR KEDSIMFNGE RYTLLSEIKN
260 270 280 290 300
GAPLTSLFNI LSLFTDDLQL HKNFDSAVNS PMTSASDVPN MSLSSDGSDD
310 320 330 340 350
LQKGEPQFGE PRLSEKPAAK LSVTVRAATD STIAIIPAAA FRRITKKFPQ
360 370 380 390 400
ATAHIVQVIL TRFQRVTFQT GHHYFGLTPE IFQTEVNLNS HARNELPGYL
410 420 430 440 450
REGAVKKLNQ VYDASQMGGR PKKYTVTLNK KNKGKGSRRQ RFSVQLNNQG
460 470 480 490 500
HLNSQSRMVS LDSLEAVGDH MNPGDLLTNV PLSRQGRPVF ELSSVKHKAS
510 520 530 540 550
IQNLSFSGND DENEDTALRT ALVEAIFKVL GIDRDSIQSS IMAVKTMSNT
560 570 580 590 600
ASPMFTGATT GGSSGSLGEE LRSRRTGQDS LGASHFGVGL PSERSQNSFY
610 620 630 640 650
ARSETSTSSV DEDSLMAAPF DTIRNDVAQY MDVVLFKKDS LLIKQDDPTP
660 670 680 690 700
GLYYLIDGVL EVGYTDHHKI YHDLYTVQPG GVGGYIGSIL GHRSFADLRA
710 720 730 740 750
RTDVYAGFLP RAAIERMSDK YPMVHLTMAK SLTKVLSRLL LHLDFAMEWV
760 770 780 790 800
QVRAGQKIYK EGQEADAIYI VLNGRVRSVA ETKGDSGIVG GESGDAKDGK
810 820 830 840 850
SHRKNLTSIG EYGKGESVGE LEVLTLTRRP STLVAIRDAE LAKIPRALFE
860 870 880 890 900
SLALHYPSIT FEISRIVASR VRTLMEDSAP IPRRMHTFDM AAHHDSYLTI
910 920 930 940 950
AVVPISQDVD VSEFGRRLYN GMQAVGREAC HLNHASVLNH MGRHAFNPLG
960 970 980 990 1000
KLKLSGFLDD IEDRYQTVLY VADTPPGSSW THTCISQADC VLLVADARSE
1010 1020 1030 1040 1050
PDIGEYERVL VKMRTTARTE MVLIHPERYV PPGLTSAWLK PRVWVHTHHH
1060 1070 1080 1090 1100
VQMDLPRHEA DVLASIRKMK RTGTLANLKN KVQTIQEEFR SMYRPKANIY
1110 1120 1130 1140 1150
STSSANKDDF NRLARILSGQ AIGLVLGGGG ARGISHIGII KALEDSGIPI
1160 1170 1180 1190 1200
DFVGGTSIGS FIGGLYAKEY DLVPIYGRAK KFSGRVSSLW RMALDLTYPA
1210 1220 1230 1240 1250
TSYTTGHEFN RGIWKAFGDS RIEDFWLRYF TNTTNITHSR MEIHTSGYAW
1260 1270 1280 1290 1300
RYIRASMSLA GLLPPLTDNG SMLLDGGYVD NLPVSEMKAQ GASVVFAVDV
1310 1320 1330 1340 1350
GSIDDTTPMN YGDSLSGAWV MWNRWNPFGR HPNVPNLAEI QARLAYVSSV
1360 1370 1380 1390 1400
GALEKAKHTP GVIYMRPPID DFATLDFAKF LDIYRVGNKY GHKFLTELRE
1410 1420
DGKFPAIPGM ENVKTKHKRT IARRNSI
Length:1,427
Mass (Da):158,153
Last modified:August 16, 2004 - v1
Checksum:i7A0F25C6577907B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82990.1.
RefSeqiXP_500744.1. XM_500744.1.

Genome annotation databases

EnsemblFungiiCAG82990; CAG82990; YALI0_B11044g.
GeneIDi2906874.
KEGGiyli:YALI0B11044g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG82990.1.
RefSeqiXP_500744.1. XM_500744.1.

3D structure databases

ProteinModelPortaliQ6CF18.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.XP_500744.1.

Proteomic databases

PRIDEiQ6CF18.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG82990; CAG82990; YALI0_B11044g.
GeneIDi2906874.
KEGGiyli:YALI0B11044g.

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000048680.
InParanoidiQ6CF18.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTE1_YARLI
AccessioniPrimary (citable) accession number: Q6CF18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.