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Q6CF18 (NTE1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:YALI0B11044g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length1427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14271427Lysophospholipase NTE1
PRO_0000295332

Regions

Topological domain1 – 6060Cytoplasmic By similarity
Transmembrane61 – 8121Helical; Potential
Topological domain82 – 9615Lumenal By similarity
Transmembrane97 – 11721Helical; Potential
Topological domain118 – 14271310Cytoplasmic By similarity
Domain1124 – 1288165Patatin
Nucleotide binding615 – 735121cNMP 1
Nucleotide binding731 – 870140cNMP 2
Motif1155 – 11595GXSXG

Sites

Active site11571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CF18 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 7A0F25C6577907B7

FASTA1,427158,153
        10         20         30         40         50         60 
MDSLHVSSTS VLVDVVEAVE TATSLVVDTA EAVATEQATP TAVISNALAR SAYAAHTSLS 

        70         80         90        100        110        120 
YLAWAFGLWF LRLIGWVCYG IPTYVLGLLG RTINISLQFS SLLLILIALV TVVVAVVRYK 

       130        140        150        160        170        180 
YLTVYSRLPQ EQPRQEPEID MYDESDNEDE KTGFANYFDE FLSAVKIFGY LERPVFHELT 

       190        200        210        220        230        240 
RHMQTWKLSA DEMVPLDDEQ GFSVVVEGTV QVFAKQSSFV QNPTSVPDSR KEDSIMFNGE 

       250        260        270        280        290        300 
RYTLLSEIKN GAPLTSLFNI LSLFTDDLQL HKNFDSAVNS PMTSASDVPN MSLSSDGSDD 

       310        320        330        340        350        360 
LQKGEPQFGE PRLSEKPAAK LSVTVRAATD STIAIIPAAA FRRITKKFPQ ATAHIVQVIL 

       370        380        390        400        410        420 
TRFQRVTFQT GHHYFGLTPE IFQTEVNLNS HARNELPGYL REGAVKKLNQ VYDASQMGGR 

       430        440        450        460        470        480 
PKKYTVTLNK KNKGKGSRRQ RFSVQLNNQG HLNSQSRMVS LDSLEAVGDH MNPGDLLTNV 

       490        500        510        520        530        540 
PLSRQGRPVF ELSSVKHKAS IQNLSFSGND DENEDTALRT ALVEAIFKVL GIDRDSIQSS 

       550        560        570        580        590        600 
IMAVKTMSNT ASPMFTGATT GGSSGSLGEE LRSRRTGQDS LGASHFGVGL PSERSQNSFY 

       610        620        630        640        650        660 
ARSETSTSSV DEDSLMAAPF DTIRNDVAQY MDVVLFKKDS LLIKQDDPTP GLYYLIDGVL 

       670        680        690        700        710        720 
EVGYTDHHKI YHDLYTVQPG GVGGYIGSIL GHRSFADLRA RTDVYAGFLP RAAIERMSDK 

       730        740        750        760        770        780 
YPMVHLTMAK SLTKVLSRLL LHLDFAMEWV QVRAGQKIYK EGQEADAIYI VLNGRVRSVA 

       790        800        810        820        830        840 
ETKGDSGIVG GESGDAKDGK SHRKNLTSIG EYGKGESVGE LEVLTLTRRP STLVAIRDAE 

       850        860        870        880        890        900 
LAKIPRALFE SLALHYPSIT FEISRIVASR VRTLMEDSAP IPRRMHTFDM AAHHDSYLTI 

       910        920        930        940        950        960 
AVVPISQDVD VSEFGRRLYN GMQAVGREAC HLNHASVLNH MGRHAFNPLG KLKLSGFLDD 

       970        980        990       1000       1010       1020 
IEDRYQTVLY VADTPPGSSW THTCISQADC VLLVADARSE PDIGEYERVL VKMRTTARTE 

      1030       1040       1050       1060       1070       1080 
MVLIHPERYV PPGLTSAWLK PRVWVHTHHH VQMDLPRHEA DVLASIRKMK RTGTLANLKN 

      1090       1100       1110       1120       1130       1140 
KVQTIQEEFR SMYRPKANIY STSSANKDDF NRLARILSGQ AIGLVLGGGG ARGISHIGII 

      1150       1160       1170       1180       1190       1200 
KALEDSGIPI DFVGGTSIGS FIGGLYAKEY DLVPIYGRAK KFSGRVSSLW RMALDLTYPA 

      1210       1220       1230       1240       1250       1260 
TSYTTGHEFN RGIWKAFGDS RIEDFWLRYF TNTTNITHSR MEIHTSGYAW RYIRASMSLA 

      1270       1280       1290       1300       1310       1320 
GLLPPLTDNG SMLLDGGYVD NLPVSEMKAQ GASVVFAVDV GSIDDTTPMN YGDSLSGAWV 

      1330       1340       1350       1360       1370       1380 
MWNRWNPFGR HPNVPNLAEI QARLAYVSSV GALEKAKHTP GVIYMRPPID DFATLDFAKF 

      1390       1400       1410       1420 
LDIYRVGNKY GHKFLTELRE DGKFPAIPGM ENVKTKHKRT IARRNSI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382128 Genomic DNA. Translation: CAG82990.1.
RefSeqXP_500744.1. XM_500744.1.

3D structure databases

ProteinModelPortalQ6CF18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CF18.

Proteomic databases

PRIDEQ6CF18.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82990; CAG82990; YALI0_B11044g.
GeneID2906874.
KEGGyli:YALI0B11044g.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000048680.
KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 4 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_YARLI
AccessionPrimary (citable) accession number: Q6CF18
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families