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Q6CF18

- NTE1_YARLI

UniProt

Q6CF18 - NTE1_YARLI

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1157 – 11571By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi615 – 735121cNMP 1Add
    BLAST
    Nucleotide bindingi731 – 870140cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:YALI0B11044g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome B

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14271427Lysophospholipase NTE1PRO_0000295332Add
    BLAST

    Proteomic databases

    PRIDEiQ6CF18.

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CF18.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CF18.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6060CytoplasmicBy similarityAdd
    BLAST
    Topological domaini82 – 9615LumenalBy similarityAdd
    BLAST
    Topological domaini118 – 14271310CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 8121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1124 – 1288165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1155 – 11595GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000048680.
    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 4 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6CF18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSLHVSSTS VLVDVVEAVE TATSLVVDTA EAVATEQATP TAVISNALAR     50
    SAYAAHTSLS YLAWAFGLWF LRLIGWVCYG IPTYVLGLLG RTINISLQFS 100
    SLLLILIALV TVVVAVVRYK YLTVYSRLPQ EQPRQEPEID MYDESDNEDE 150
    KTGFANYFDE FLSAVKIFGY LERPVFHELT RHMQTWKLSA DEMVPLDDEQ 200
    GFSVVVEGTV QVFAKQSSFV QNPTSVPDSR KEDSIMFNGE RYTLLSEIKN 250
    GAPLTSLFNI LSLFTDDLQL HKNFDSAVNS PMTSASDVPN MSLSSDGSDD 300
    LQKGEPQFGE PRLSEKPAAK LSVTVRAATD STIAIIPAAA FRRITKKFPQ 350
    ATAHIVQVIL TRFQRVTFQT GHHYFGLTPE IFQTEVNLNS HARNELPGYL 400
    REGAVKKLNQ VYDASQMGGR PKKYTVTLNK KNKGKGSRRQ RFSVQLNNQG 450
    HLNSQSRMVS LDSLEAVGDH MNPGDLLTNV PLSRQGRPVF ELSSVKHKAS 500
    IQNLSFSGND DENEDTALRT ALVEAIFKVL GIDRDSIQSS IMAVKTMSNT 550
    ASPMFTGATT GGSSGSLGEE LRSRRTGQDS LGASHFGVGL PSERSQNSFY 600
    ARSETSTSSV DEDSLMAAPF DTIRNDVAQY MDVVLFKKDS LLIKQDDPTP 650
    GLYYLIDGVL EVGYTDHHKI YHDLYTVQPG GVGGYIGSIL GHRSFADLRA 700
    RTDVYAGFLP RAAIERMSDK YPMVHLTMAK SLTKVLSRLL LHLDFAMEWV 750
    QVRAGQKIYK EGQEADAIYI VLNGRVRSVA ETKGDSGIVG GESGDAKDGK 800
    SHRKNLTSIG EYGKGESVGE LEVLTLTRRP STLVAIRDAE LAKIPRALFE 850
    SLALHYPSIT FEISRIVASR VRTLMEDSAP IPRRMHTFDM AAHHDSYLTI 900
    AVVPISQDVD VSEFGRRLYN GMQAVGREAC HLNHASVLNH MGRHAFNPLG 950
    KLKLSGFLDD IEDRYQTVLY VADTPPGSSW THTCISQADC VLLVADARSE 1000
    PDIGEYERVL VKMRTTARTE MVLIHPERYV PPGLTSAWLK PRVWVHTHHH 1050
    VQMDLPRHEA DVLASIRKMK RTGTLANLKN KVQTIQEEFR SMYRPKANIY 1100
    STSSANKDDF NRLARILSGQ AIGLVLGGGG ARGISHIGII KALEDSGIPI 1150
    DFVGGTSIGS FIGGLYAKEY DLVPIYGRAK KFSGRVSSLW RMALDLTYPA 1200
    TSYTTGHEFN RGIWKAFGDS RIEDFWLRYF TNTTNITHSR MEIHTSGYAW 1250
    RYIRASMSLA GLLPPLTDNG SMLLDGGYVD NLPVSEMKAQ GASVVFAVDV 1300
    GSIDDTTPMN YGDSLSGAWV MWNRWNPFGR HPNVPNLAEI QARLAYVSSV 1350
    GALEKAKHTP GVIYMRPPID DFATLDFAKF LDIYRVGNKY GHKFLTELRE 1400
    DGKFPAIPGM ENVKTKHKRT IARRNSI 1427
    Length:1,427
    Mass (Da):158,153
    Last modified:August 16, 2004 - v1
    Checksum:i7A0F25C6577907B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82990.1.
    RefSeqiXP_500744.1. XM_500744.1.

    Genome annotation databases

    EnsemblFungiiCAG82990; CAG82990; YALI0_B11044g.
    GeneIDi2906874.
    KEGGiyli:YALI0B11044g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG82990.1 .
    RefSeqi XP_500744.1. XM_500744.1.

    3D structure databases

    ProteinModelPortali Q6CF18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CF18.

    Proteomic databases

    PRIDEi Q6CF18.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82990 ; CAG82990 ; YALI0_B11044g .
    GeneIDi 2906874.
    KEGGi yli:YALI0B11044g.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000048680.
    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 4 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiNTE1_YARLI
    AccessioniPrimary (citable) accession number: Q6CF18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3