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Q6CES3

- MTAP_YARLI

UniProt

Q6CES3 - MTAP_YARLI

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

MEU1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei30 – 301PhosphateUniRule annotation
Sitei197 – 1971Important for substrate specificityUniRule annotation
Binding sitei215 – 2151Substrate; via amide nitrogenUniRule annotation
Binding sitei216 – 2161PhosphateUniRule annotation
Sitei252 – 2521Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Short name:
MTAPaseUniRule annotation
Gene namesi
Name:MEU1UniRule annotation
Ordered Locus Names:YALI0B13420g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Cytoplasm UniRule annotation. Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321S-methyl-5'-thioadenosine phosphorylasePRO_0000415138Add
BLAST

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi4952.Q6CES3.

Structurei

3D structure databases

ProteinModelPortaliQ6CES3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni73 – 742Phosphate bindingUniRule annotation
Regioni106 – 1072Phosphate bindingUniRule annotation
Regioni239 – 2413Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000228986.
InParanoidiQ6CES3.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG77DJGM.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CES3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFLPNLVAT PMSLASSYSK PVTLGIIGGT GLYKLGALTP VAQIDIDTPW
60 70 80 90 100
GKPSSPITIS ETKSGFPVAF LARHGVNHDL TPTDVPSRAN IAALKKVGVK
110 120 130 140 150
AIVAFSAVGS LQEEIAPRDF VVPTQIIDRT KGIRPSSFFE KGFVGHVGFG
160 170 180 190 200
EPFDVALGKL VAEHADKAFD NSKYKIHTKA KAGKDLTLVC MEGPAFSTRA
210 220 230 240 250
ESQLYRSWNG AVINMSAIPE SKLAKEAEIA YQMICMSTDY DAWKEDEEPV
260 270 280 290 300
TVEQVVSNLT ANAESATGVV EALLEPLEKA LADKSIGYDL DGSMKFAVST
310 320
APAARDATVA KNLDFLHPGY W
Length:321
Mass (Da):34,334
Last modified:August 16, 2004 - v1
Checksum:iD6990F820951377F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG83090.1.
RefSeqiXP_500839.1. XM_500839.1.

Genome annotation databases

EnsemblFungiiCAG83090; CAG83090; YALI0_B13420g.
GeneIDi2907414.
KEGGiyli:YALI0B13420g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG83090.1 .
RefSeqi XP_500839.1. XM_500839.1.

3D structure databases

ProteinModelPortali Q6CES3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CES3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83090 ; CAG83090 ; YALI0_B13420g .
GeneIDi 2907414.
KEGGi yli:YALI0B13420g.

Phylogenomic databases

HOGENOMi HOG000228986.
InParanoidi Q6CES3.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG77DJGM.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiMTAP_YARLI
AccessioniPrimary (citable) accession number: Q6CES3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3