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Q6CEH4 (Q6CEH4_YARLI) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:YALI0B15598g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding17 – 226NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding40 – 423NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding82 – 843NADP By similarity PIRSR PIRSR000109-3
Region136 – 1383Substrate binding By similarity PIRSR PIRSR000109-2
Region193 – 1942Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1901Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1971Proton donor By similarity PIRSR PIRSR000109-1
Binding site1101NADP By similarity PIRSR PIRSR000109-3
Binding site1101Substrate By similarity PIRSR PIRSR000109-2
Binding site1981Substrate By similarity PIRSR PIRSR000109-2
Binding site2671Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2941Substrate By similarity PIRSR PIRSR000109-2
Binding site4531Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4591Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q6CEH4 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 48F140D4C6827D63

FASTA48953,587
        10         20         30         40         50         60 
MTDTSNIKPV ADIALIGLAV MGQNLILNMA DHGYEVVAYN RTTSKVDHFL ENEAKGKSII 

        70         80         90        100        110        120 
GAHSIKELCA LLKRPRRIIL LVKAGAAVDS FIEQLLPYLD KGDIIIDGGN SHFPDSNRRY 

       130        140        150        160        170        180 
EELNEKGILF VGSGVSGGEE GARYGPSIMP GGNKEAWPHI KKIFQDISAK ADGEPCCDWV 

       190        200        210        220        230        240 
GDAGAGHFVK MVHNGIEYGD MQLICEAYDL MKRGAGFTNE EIGDVFAKWN NGILDSFLIE 

       250        260        270        280        290        300 
ITRDIFKYDD GSGTPLVEKI SDTAGQKGTG KWTAINALDL GMPVTLIGEA VFARCLSALK 

       310        320        330        340        350        360 
QERVRASKVL DGPEPVKFTG DKKEFVDQLE QALYASKIIS YAQGFMLIRE AAKTYGWELN 

       370        380        390        400        410        420 
NAGIALMWRG GCIIRSVFLA DITKAYRQDP NLENLLFNDF FKNAISKANP SWRATVAKAV 

       430        440        450        460        470        480 
TWGVPTPAFA SALAFYDGYR SAKLPANLLQ AQRDYFGAHT YQLLDGDGKW IHTNWTGRGG 


EVSSSTYDA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR382128 Genomic DNA. Translation: CAG83189.1.
RefSeqXP_500938.1. XM_500938.1.

3D structure databases

ProteinModelPortalQ6CEH4.
SMRQ6CEH4. Positions 11-476.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6CEH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2906913.
GenomeReviewsGene locus YALI0B15598g in contig CR382128_GR.
KEGGyli:YALI0B15598g.

Phylogenomic databases

eggNOGfuNOG05795.
HOGENOMHBG286913.
OMASNYPDTN.
OrthoDBEOG4VDT6Z.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6CEH4_YARLI
AccessionPrimary (citable) accession number: Q6CEH4
Entry history
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info