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Q6CEE1 (NAGS_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Amino-acid acetyltransferase, mitochondrial

EC=2.3.1.1
Alternative name(s):
Arginine-requiring protein 2
Glutamate N-acetyltransferase
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS
Gene names
Name:ARG2
Ordered Locus Names:YALI0B16390g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

N-acetylglutamate synthase involved in arginine biosynthesis By similarity.

Catalytic activity

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the acetyltransferase family.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
   Cellular componentMitochondrion
   DomainTransit peptide
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacetyl-CoA:L-glutamate N-acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 608Amino-acid acetyltransferase, mitochondrialPRO_0000372583

Regions

Domain402 – 593192N-acetyltransferase
Compositional bias478 – 48811Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q6CEE1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5609EFE173123BDE

FASTA60867,106
        10         20         30         40         50         60 
MLRSSRITAG TCVSRGWHSY TTKTPTKTAI PPAAKSSNEA KDLILSVLQS AATKREAKTY 

        70         80         90        100        110        120 
ISRYAPLTGV ELQKKKEGLV QRLLGVGKEQ DNKEIENLTG HAPEGLLGDS EGTLRVAIIK 

       130        140        150        160        170        180 
IRDIKSIEDD LIAQMGETIA RLSRLGVSPI VVVDAGKARN DFLKLDNKPF RHYQKLILQK 

       190        200        210        220        230        240 
VFKISDAIDA ASPDVGARPI EGLFSMNKKG LRLAMPQMLM HPLSHGKVPV LAPLAYDDVT 

       250        260        270        280        290        300 
SEEKLVMADD VVHFLTQKLA EVPANILSVE KIIFVDPLGG IPSVERSGAH VFVNLKQELS 

       310        320        330        340        350        360 
DIAAELHMGF IPPAQREVHL ANLKAMHKAL KFLPPTASGL ITTPAVAAIP SVGRNPIIYN 

       370        380        390        400        410        420 
VLTDRPVISP SLPVELKKTP TLETTLLREG MPVITLKSDK GLNLITEHEK GNIDLDRLWH 

       430        440        450        460        470        480 
LIEDSFGRRI DKQHYLNRVN GKIAGIIIAG DYEGAAIITW EDIDPVKAQE DRDAADRAAA 

       490        500        510        520        530        540 
EAAAAYAAGI PLPSPPLYQK LGDAVPLNPN QVAYLDKFAV LKRSQGSSSV ADVVFKGMVM 

       550        560        570        580        590        600 
SQFPNELLWR SRKNNPVNKW YFDRSKGSFK IPGSEWCMFW TGRKTREQYL ERFVDICTRI 


EPSLREEL 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382128 Genomic DNA. Translation: CAG83224.1.
RefSeqXP_500971.1. XM_500971.1.

3D structure databases

ProteinModelPortalQ6CEE1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CEE1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG83224; CAG83224; YALI0_B16390g.
GeneID2907516.
KEGGyli:YALI0B16390g.

Phylogenomic databases

eggNOGCOG5630.
HOGENOMHOG000111164.
KOK00618.
OMALIWRSRK.
OrthoDBEOG7J1896.

Enzyme and pathway databases

UniPathwayUPA00068; UER00106.

Family and domain databases

InterProIPR006855. DUF619.
IPR011190. GlcNAc_Synth_fun.
[Graphical view]
PfamPF04768. DUF619. 1 hit.
[Graphical view]
PIRSFPIRSF007892. NAGS_fungal. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNAGS_YARLI
AccessionPrimary (citable) accession number: Q6CEE1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways