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Q6CE48

- IND1_YARLI

UniProt

Q6CE48 - IND1_YARLI

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Protein

Iron-sulfur protein IND1

Gene

IND1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I.1 Publication

Cofactori

Binds 1 4Fe-4S cluster.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 828ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur protein IND1
Alternative name(s):
Iron-sulfur protein required for NADH dehydrogenase 1
Gene namesi
Name:IND1
Ordered Locus Names:YALI0B18590g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi242 – 2421C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication
Mutagenesisi245 – 2451C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication
Mutagenesisi279 – 2791C → A or S: No effect. 1 Publication
Mutagenesisi279 – 2791C → E: Abolishes most of complex I activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion1 PublicationAdd
BLAST
Chaini35 – 312278Iron-sulfur protein IND1PRO_0000352527Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CE48.

Structurei

3D structure databases

ProteinModelPortaliQ6CE48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0489.
HOGENOMiHOG000079916.
InParanoidiQ6CE48.
KOiK03593.
OMAiPLLMNVH.
OrthoDBiEOG70CRJC.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR025669. AAA_dom.
IPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF13614. AAA_31. 1 hit.
PF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CE48 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGFRLIAPI QRSIAIISRL QPITANFHSS PALRSHENPL GIPKSPASAP
60 70 80 90 100
RIPRKTTRRP EPIAGVKKTI VVSSAKGGVG KSTVSVNTAL SLAKRGLRVG
110 120 130 140 150
LLDVDIFGPS IPTMFGLSGE PRMTHEGKLI PMSKFGIQVM SMGFLVDPNK
160 170 180 190 200
AVAWRGLLVQ KALEQLLQDV DWGTLDVLVM DLPPGTGDVQ LTIAQTVKID
210 220 230 240 250
GAIIVSTPQD VALVDVVRGL DLFEKTYTKV LGLVQNMSVF VCPNCNHETH
260 270 280 290 300
IFGVDGAVSK AKSRGLGVLG NVPLDPQICS QSDKGVPVAV SGGVQAKYYD
310
KIAEGVAEQL GV
Length:312
Mass (Da):33,167
Last modified:August 16, 2004 - v1
Checksum:i25F5F96432C8A327
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83317.1.
RefSeqiXP_501064.1. XM_501064.1.

Genome annotation databases

EnsemblFungiiCAG83317; CAG83317; YALI0_B18590g.
GeneIDi2907193.
KEGGiyli:YALI0B18590g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83317.1 .
RefSeqi XP_501064.1. XM_501064.1.

3D structure databases

ProteinModelPortali Q6CE48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CE48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83317 ; CAG83317 ; YALI0_B18590g .
GeneIDi 2907193.
KEGGi yli:YALI0B18590g.

Phylogenomic databases

eggNOGi COG0489.
HOGENOMi HOG000079916.
InParanoidi Q6CE48.
KOi K03593.
OMAi PLLMNVH.
OrthoDBi EOG70CRJC.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR025669. AAA_dom.
IPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23264. PTHR23264. 1 hit.
Pfami PF13614. AAA_31. 1 hit.
PF10609. ParA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS01215. MRP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIB 122 / E 150.
  2. "The iron-sulphur protein Ind1 is required for effective complex I assembly."
    Bych K., Kerscher S., Netz D.J.A., Pierik A.J., Zwicker K., Huynen M.A., Lill R., Brandt U., Balk J.
    EMBO J. 27:1736-1746(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-38, FUNCTION, COFACTOR, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-242; CYS-245 AND CYS-279.

Entry informationi

Entry nameiIND1_YARLI
AccessioniPrimary (citable) accession number: Q6CE48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3