Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Iron-sulfur protein IND1

Gene

IND1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I.1 Publication

Cofactori

[4Fe-4S] cluster1 PublicationNote: Binds 1 [4Fe-4S] cluster.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 82ATPSequence analysis8

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur protein IND1
Alternative name(s):
Iron-sulfur protein required for NADH dehydrogenase 1
Gene namesi
Name:IND1
Ordered Locus Names:YALI0B18590g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome B

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi242C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication1
Mutagenesisi245C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication1
Mutagenesisi279C → A or S: No effect. 1 Publication1
Mutagenesisi279C → E: Abolishes most of complex I activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000035252735 – 312Iron-sulfur protein IND1Add BLAST278

Structurei

3D structure databases

ProteinModelPortaliQ6CE48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000079916.
InParanoidiQ6CE48.
KOiK03593.
OMAiIIPLTNH.
OrthoDBiEOG092C4BLN.

Family and domain databases

CDDicd02037. MRP-like. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
IPR033756. YlxH/NBP35.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CE48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFRLIAPI QRSIAIISRL QPITANFHSS PALRSHENPL GIPKSPASAP
60 70 80 90 100
RIPRKTTRRP EPIAGVKKTI VVSSAKGGVG KSTVSVNTAL SLAKRGLRVG
110 120 130 140 150
LLDVDIFGPS IPTMFGLSGE PRMTHEGKLI PMSKFGIQVM SMGFLVDPNK
160 170 180 190 200
AVAWRGLLVQ KALEQLLQDV DWGTLDVLVM DLPPGTGDVQ LTIAQTVKID
210 220 230 240 250
GAIIVSTPQD VALVDVVRGL DLFEKTYTKV LGLVQNMSVF VCPNCNHETH
260 270 280 290 300
IFGVDGAVSK AKSRGLGVLG NVPLDPQICS QSDKGVPVAV SGGVQAKYYD
310
KIAEGVAEQL GV
Length:312
Mass (Da):33,167
Last modified:August 16, 2004 - v1
Checksum:i25F5F96432C8A327
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG83317.1.
RefSeqiXP_501064.1. XM_501064.1.

Genome annotation databases

EnsemblFungiiCAG83317; CAG83317; YALI0_B18590g.
GeneIDi2907193.
KEGGiyli:YALI0B18590g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382128 Genomic DNA. Translation: CAG83317.1.
RefSeqiXP_501064.1. XM_501064.1.

3D structure databases

ProteinModelPortaliQ6CE48.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG83317; CAG83317; YALI0_B18590g.
GeneIDi2907193.
KEGGiyli:YALI0B18590g.

Phylogenomic databases

HOGENOMiHOG000079916.
InParanoidiQ6CE48.
KOiK03593.
OMAiIIPLTNH.
OrthoDBiEOG092C4BLN.

Family and domain databases

CDDicd02037. MRP-like. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_02040. Mrp_NBP35. 1 hit.
InterProiIPR019591. Mrp/NBP35_ATP-bd.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
IPR033756. YlxH/NBP35.
[Graphical view]
PANTHERiPTHR23264. PTHR23264. 1 hit.
PfamiPF10609. ParA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIND1_YARLI
AccessioniPrimary (citable) accession number: Q6CE48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.