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Q6CE48

- IND1_YARLI

UniProt

Q6CE48 - IND1_YARLI

Protein

Iron-sulfur protein IND1

Gene

IND1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I.1 Publication

    Cofactori

    Binds 1 4Fe-4S cluster.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 828ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron-sulfur protein IND1
    Alternative name(s):
    Iron-sulfur protein required for NADH dehydrogenase 1
    Gene namesi
    Name:IND1
    Ordered Locus Names:YALI0B18590g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome B

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Peripheral membrane protein 1 Publication; Matrix side 1 Publication

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi242 – 2421C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication
    Mutagenesisi245 – 2451C → A, E or S: Reduces the amount of fully assembled complex I. 1 Publication
    Mutagenesisi279 – 2791C → A or S: No effect. 1 Publication
    Mutagenesisi279 – 2791C → E: Abolishes most of complex I activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3434Mitochondrion1 PublicationAdd
    BLAST
    Chaini35 – 312278Iron-sulfur protein IND1PRO_0000352527Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CE48.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CE48.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0489.
    HOGENOMiHOG000079916.
    KOiK03593.
    OMAiPLLMNVH.
    OrthoDBiEOG70CRJC.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR025669. AAA_dom.
    IPR019591. Mrp/NBP35_ATP-bd.
    IPR000808. Mrp_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR23264. PTHR23264. 1 hit.
    PfamiPF13614. AAA_31. 1 hit.
    PF10609. ParA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS01215. MRP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CE48-1 [UniParc]FASTAAdd to Basket

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    MRGFRLIAPI QRSIAIISRL QPITANFHSS PALRSHENPL GIPKSPASAP    50
    RIPRKTTRRP EPIAGVKKTI VVSSAKGGVG KSTVSVNTAL SLAKRGLRVG 100
    LLDVDIFGPS IPTMFGLSGE PRMTHEGKLI PMSKFGIQVM SMGFLVDPNK 150
    AVAWRGLLVQ KALEQLLQDV DWGTLDVLVM DLPPGTGDVQ LTIAQTVKID 200
    GAIIVSTPQD VALVDVVRGL DLFEKTYTKV LGLVQNMSVF VCPNCNHETH 250
    IFGVDGAVSK AKSRGLGVLG NVPLDPQICS QSDKGVPVAV SGGVQAKYYD 300
    KIAEGVAEQL GV 312
    Length:312
    Mass (Da):33,167
    Last modified:August 16, 2004 - v1
    Checksum:i25F5F96432C8A327
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG83317.1.
    RefSeqiXP_501064.1. XM_501064.1.

    Genome annotation databases

    EnsemblFungiiCAG83317; CAG83317; YALI0_B18590g.
    GeneIDi2907193.
    KEGGiyli:YALI0B18590g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382128 Genomic DNA. Translation: CAG83317.1 .
    RefSeqi XP_501064.1. XM_501064.1.

    3D structure databases

    ProteinModelPortali Q6CE48.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CE48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG83317 ; CAG83317 ; YALI0_B18590g .
    GeneIDi 2907193.
    KEGGi yli:YALI0B18590g.

    Phylogenomic databases

    eggNOGi COG0489.
    HOGENOMi HOG000079916.
    KOi K03593.
    OMAi PLLMNVH.
    OrthoDBi EOG70CRJC.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR025669. AAA_dom.
    IPR019591. Mrp/NBP35_ATP-bd.
    IPR000808. Mrp_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR23264. PTHR23264. 1 hit.
    Pfami PF13614. AAA_31. 1 hit.
    PF10609. ParA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS01215. MRP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CLIB 122 / E 150.
    2. "The iron-sulphur protein Ind1 is required for effective complex I assembly."
      Bych K., Kerscher S., Netz D.J.A., Pierik A.J., Zwicker K., Huynen M.A., Lill R., Brandt U., Balk J.
      EMBO J. 27:1736-1746(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 35-38, FUNCTION, COFACTOR, SUBCELLULAR LOCATION, MUTAGENESIS OF CYS-242; CYS-245 AND CYS-279.

    Entry informationi

    Entry nameiIND1_YARLI
    AccessioniPrimary (citable) accession number: Q6CE48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3