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Q6CE48 (IND1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Iron-sulfur protein IND1
Alternative name(s):
Iron-sulfur protein required for NADH dehydrogenase 1
Gene names
Name:IND1
Ordered Locus Names:YALI0B18590g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for the effective assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Probably facilitates the assembly of Fe-S cofactors and subunits of complex I. Ref.2

Cofactor

Binds 1 4Fe-4S cluster. Ref.2

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side Ref.2.

Sequence similarities

Belongs to the Mrp/NBP35 ATP-binding proteins family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3434Mitochondrion Ref.2
Chain35 – 312278Iron-sulfur protein IND1
PRO_0000352527

Regions

Nucleotide binding75 – 828ATP Potential

Experimental info

Mutagenesis2421C → A, E or S: Reduces the amount of fully assembled complex I. Ref.2
Mutagenesis2451C → A, E or S: Reduces the amount of fully assembled complex I. Ref.2
Mutagenesis2791C → A or S: No effect. Ref.2
Mutagenesis2791C → E: Abolishes most of complex I activity. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6CE48 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 25F5F96432C8A327

FASTA31233,167
        10         20         30         40         50         60 
MRGFRLIAPI QRSIAIISRL QPITANFHSS PALRSHENPL GIPKSPASAP RIPRKTTRRP 

        70         80         90        100        110        120 
EPIAGVKKTI VVSSAKGGVG KSTVSVNTAL SLAKRGLRVG LLDVDIFGPS IPTMFGLSGE 

       130        140        150        160        170        180 
PRMTHEGKLI PMSKFGIQVM SMGFLVDPNK AVAWRGLLVQ KALEQLLQDV DWGTLDVLVM 

       190        200        210        220        230        240 
DLPPGTGDVQ LTIAQTVKID GAIIVSTPQD VALVDVVRGL DLFEKTYTKV LGLVQNMSVF 

       250        260        270        280        290        300 
VCPNCNHETH IFGVDGAVSK AKSRGLGVLG NVPLDPQICS QSDKGVPVAV SGGVQAKYYD 

       310 
KIAEGVAEQL GV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382128 Genomic DNA. Translation: CAG83317.1.
RefSeqXP_501064.1. XM_501064.1.

3D structure databases

ProteinModelPortalQ6CE48.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CE48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG83317; CAG83317; YALI0_B18590g.
GeneID2907193.
KEGGyli:YALI0B18590g.

Phylogenomic databases

eggNOGCOG0489.
HOGENOMHOG000079916.
KOK03593.
OMAVRTHNDI.
OrthoDBEOG70CRJC.

Family and domain databases

InterProIPR025669. AAA_dom.
IPR019591. ATPase-like_ParA/MinD.
IPR000808. Mrp_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF13614. AAA_31. 1 hit.
PF10609. ParA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS01215. MRP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIND1_YARLI
AccessionPrimary (citable) accession number: Q6CE48
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families