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Q6CE12

- TRMB_YARLI

UniProt

Q6CE12 - TRMB_YARLI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene
TRM8, YALI0B19558g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei188 – 1881S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei191 – 1911 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
Transfer RNA methyltransferase 8
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:TRM8
Ordered Locus Names:YALI0B19558g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292tRNA (guanine-N(7)-)-methyltransferaseUniRule annotationPRO_0000370606Add
BLAST

Interactioni

Subunit structurei

Forms a complex with TRM82 By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi4952.Q6CE12.

Structurei

3D structure databases

ProteinModelPortaliQ6CE12.
SMRiQ6CE12. Positions 73-290.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1342S-adenosyl-L-methionine binding By similarity
Regioni168 – 1692S-adenosyl-L-methionine binding By similarity
Regioni266 – 2683S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000260965.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG708W9T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CE12-1 [UniParc]FASTAAdd to Basket

« Hide

MLKRDQSEMD IEAETANMGK EEKESFVHKR QKYRQEQEEK RLAAKKGVSF    50
EQPEDGEIKL PKKRYYRQRA HSNPFSDHQL EYPESPADMD WDVLYPNRKE 100
GQKVEVADIG CGFGGLLVAL SPQLPNQLIL GMEIRVQVTN YVEDRIVALR 150
HQNKETDGYQ NISVLRGNAM KFLPNFFEKG QLSKIFFCFP DPHFKQRKHK 200
ARIVTTTLCS EYAYVVRPGG IVYTITDVKD LHEWMVKHLA AHPLFERLTK 250
EEEDADPCVA TMLVETEEGK KVARNEGDKF VACFRRKENP EW 292
Length:292
Mass (Da):33,982
Last modified:August 16, 2004 - v1
Checksum:iEB71F2EF1F73C1D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83353.1.
RefSeqiXP_501100.1. XM_501100.1.

Genome annotation databases

EnsemblFungiiCAG83353; CAG83353; YALI0_B19558g.
GeneIDi2907246.
KEGGiyli:YALI0B19558g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83353.1 .
RefSeqi XP_501100.1. XM_501100.1.

3D structure databases

ProteinModelPortali Q6CE12.
SMRi Q6CE12. Positions 73-290.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CE12.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83353 ; CAG83353 ; YALI0_B19558g .
GeneIDi 2907246.
KEGGi yli:YALI0B19558g.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000260965.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG708W9T.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiTRMB_YARLI
AccessioniPrimary (citable) accession number: Q6CE12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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