Reviewed, UniProtKB/Swiss-Prot Q6CDR5 (HPPD_YARLI)

Names and origin

Protein names

Recommended name:
    4-hydroxyphenylpyruvate dioxygenase
      Short name=HPPDase
      Short name=4HPPD
      Short name=HPD
    EC=1.13.11.27

Gene names

Ordered Locus Names:

YALI0B21846g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088407
Sites
	Metal binding	196	1	Iron By similarity
	Metal binding	279	1	Iron By similarity
	Metal binding	362	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6CDR5-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 9588F1E0E3F7B95E	FASTA	394	44,190
	10 20 30 40 50 60 MSPSVEVTPA HTPTSYEVTN SLDSYRGYDH VHWYVGNAKQ AASFYITRMG FSPIAYKGLE 70 80 90 100 110 120 TGSRDVTTHV VGNGQVRFAF SSALRTGEPQ ADEIHAHLVK HGDAVKDVAF EVDNVEQLFS 130 140 150 160 170 180 AAVKKGVRVI SEPKVLKDAH GSVTYAVIST YGDTTHTLIE RGSYEGAFLP GFVDTSANKD 190 200 210 220 230 240 PIAAFLPNIE LMHIDHCVGN QDWNEMDNAC KYYEETLGFH RFWSVDDKDI CTEFSALKSV 250 260 270 280 290 300 VMASPNEKIK MPVNEPAVGK KKSQIEEYID FYDGPGIQHI ALRTDCILDT VRDLRARGVE 310 320 330 340 350 360 FISVPGSYYE NMKERLAKSS LKLEEKFEDI QALNILIDFD EGGYLLQLFT KPLMDRPTVF 370 380 390 IEIIQRRNFE GFGAGNFKSL FEAIEREQAK RGNL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382128 Genomic DNA. Translation: CAG83450.1.
RefSeq	XP_501197.1.
3D structure databases
SMR	Q6CDR5. Positions 24-379.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CDR5.
Genome annotation databases
GeneID	2907146.
GenomeReviews	Gene locus YALI0B21846g in contig CR382128_GR.
KEGG	yli:YALI0B21846g.
Phylogenomic databases
eggNOG	fuNOG06871.
HOGENOM	HBG680392.
OMA	VQDRPTV.
OrthoDB	EOG9RZ0GJ.
PhylomeDB	Q6CDR5.
Enzyme and pathway databases
BRENDA	1.13.11.27. 3602.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_bleo-R_dOase. [Graphical view]
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 2 hits. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_YARLI

Accession

Primary (citable) accession number: Q6CDR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	August 16, 2004
Last modified:	February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)