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Q6CDM0

- KYNU_YARLI

UniProt

Q6CDM0 - KYNU_YARLI

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Protein
Kynureninase
Gene
BNA5, YALI0B22902g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei99 – 991Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei100 – 1001Pyridoxal phosphate By similarity
Binding sitei183 – 1831Pyridoxal phosphate By similarity
Binding sitei212 – 2121Pyridoxal phosphate By similarity
Binding sitei215 – 2151Pyridoxal phosphate By similarity
Binding sitei237 – 2371Pyridoxal phosphate By similarity
Binding sitei267 – 2671Pyridoxal phosphate By similarity
Binding sitei295 – 2951Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase (EC:3.7.1.3)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5
L-kynurenine hydrolase
Gene namesi
Name:BNA5
Ordered Locus Names:YALI0B22902g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome B

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437KynureninaseUniRule annotation
PRO_0000218664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei238 – 2381N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi4952.Q6CDM0.

Structurei

3D structure databases

ProteinModelPortaliQ6CDM0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1304Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiACESHIN.
OrthoDBiEOG7V1G0J.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CDM0-1 [UniParc]FASTAAdd to Basket

« Hide

MPLNFRDRFN VPVLKNGEEV AYLVGNSLGL MPHKTRDYVN QEMDAWSQLG    50
VKGHFVSGKE DLGQDVHQGP WYSCDEPLHG LVGPILGASE DEVAIMNTLT 100
SNIHSLFSAF YKPTAKRSKI LFEAKAFPSD TYAMEAQARL HNLDPSEALI 150
KLAPKDGLHT LSDDDIIKVI EEQGDEIAVV FFSGIQFYTG QLFDIPRITA 200
AAKAKGCVVG WDLAHAAGNV PLKLHDWNVD FAVFCTYKYM NSGPGGIGGL 250
FVHDKYADDQ RPRLAGWWGN NAETRFKMLD EFDPIRGARG YKQSNPSVLC 300
VLALRASLEL FKEAGGIEKL RERSIELTNR LLKGLLASPH YIAPENIEIF 350
GNSGKAWFTI ITPQAEHQRG AQLSLLFGPD GTMKKVFDYL DDHGVLGDER 400
NPDVIRLAPA PLYNNERDVD LAIKLINDSI NLINGSA 437
Length:437
Mass (Da):48,411
Last modified:August 16, 2004 - v1
Checksum:i903018CA6020F2CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83495.1.
RefSeqiXP_501242.1. XM_501242.1.

Genome annotation databases

EnsemblFungiiCAG83495; CAG83495; YALI0_B22902g.
GeneIDi2906903.
KEGGiyli:YALI0B22902g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382128 Genomic DNA. Translation: CAG83495.1 .
RefSeqi XP_501242.1. XM_501242.1.

3D structure databases

ProteinModelPortali Q6CDM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CDM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG83495 ; CAG83495 ; YALI0_B22902g .
GeneIDi 2906903.
KEGGi yli:YALI0B22902g.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
KOi K01556.
OMAi ACESHIN.
OrthoDBi EOG7V1G0J.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiKYNU_YARLI
AccessioniPrimary (citable) accession number: Q6CDM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3