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Protein

Polyadenylate-binding protein, cytoplasmic and nuclear

Gene

PAB1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA transport, Translation regulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polyadenylate-binding protein, cytoplasmic and nuclear
Short name:
PABP
Short name:
Poly(A)-binding protein
Alternative name(s):
Polyadenylate tail-binding protein
Gene namesi
Name:PAB1
Ordered Locus Names:YALI0C00539g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002954011 – 629Polyadenylate-binding protein, cytoplasmic and nuclearAdd BLAST629

Proteomic databases

PRIDEiQ6CDH3.

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_501289.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CDH3.
SMRiQ6CDH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 124RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini134 – 211RRM 2PROSITE-ProRule annotationAdd BLAST78
Domaini227 – 304RRM 3PROSITE-ProRule annotationAdd BLAST78
Domaini330 – 407RRM 4PROSITE-ProRule annotationAdd BLAST78
Domaini542 – 624PABCPROSITE-ProRule annotationAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi444 – 525Pro-richAdd BLAST82

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000217922.
InParanoidiQ6CDH3.
KOiK13126.
OMAiKKVYVGH.
OrthoDBiEOG092C3SCB.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiView protein in InterPro
IPR012677. Nucleotide-bd_a/b_plait_sf.
IPR036053. PABP-dom.
IPR006515. PABP_1234.
IPR002004. PABP_HYD.
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00658. PABP. 1 hit.
PF00076. RRM_1. 4 hits.
SMARTiView protein in SMART
SM00517. PolyA. 1 hit.
SM00360. RRM. 4 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
SSF63570. SSF63570. 2 hits.
TIGRFAMsiTIGR01628. PABP-1234. 1 hit.
PROSITEiView protein in PROSITE
PS51309. PABC. 1 hit.
PS50102. RRM. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6CDH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLENKAEAS PATKEETTTE AAPAEGEAKT ESSEEKGSKE DQGDNASLYV
60 70 80 90 100
GELDPSVTEA MLFEIFNPIG PVTSVRVCRD AITRRSLGYA YVNFHNQADG
110 120 130 140 150
IRALEELNYS PIKERPCRIM WSQRDPALRK TGAGNIYIKN LDPAIDNKAL
160 170 180 190 200
HDTFSAFGQI LSCKIATDEF GNSRGFGFVH YESAESAESA IQHVNGMLLN
210 220 230 240 250
DKKVFVGPHV PKSDRMQSFE EQKNSFTNVF IKNLGTEITE AEFEELVNKF
260 270 280 290 300
GETSSVHLST NDEGKPTGFG FVDYKEHDVA VKAIDGLSET EFKGNKLFAG
310 320 330 340 350
RAKKKYERAD ELRKQYEASR LEKLNKYQGV NLYIKNLDDT IDDDKLRAEF
360 370 380 390 400
APHGTITSAK VMVDEAGKSK GFGFVCYSSP EEATKAVTEM NHRLVAGKPL
410 420 430 440 450
YVVLAQRKDV RRSQLQQQIQ AKNQMRLQQQ AAAGGLPGQY MGNPGVFYPG
460 470 480 490 500
QPGFMPPGRG GMPFGANPQM MMRPPMPPQN QFPPRGVPGG PNMYGAPPQG
510 520 530 540 550
YQQGGFPPQG PMRGGQPPRS GQPGPQGQFR GAPRRKDGES RVADSISNAL
560 570 580 590 600
ENAPEEQHKQ LVGEALYPKV LAEKAIDGNA EFAGKITGML LEMPIKEILE
610 620
VIDDEEGLQA QINDAITAYN EYLNSQKEE
Length:629
Mass (Da):69,217
Last modified:August 16, 2004 - v1
Checksum:i6983DBFC3D86E060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG81584.1.
RefSeqiXP_501289.1. XM_501289.1.

Genome annotation databases

EnsemblFungiiCAG81584; CAG81584; YALI0_C00539g.
GeneIDi2909177.
KEGGiyli:YALI0C00539g.

Similar proteinsi

Entry informationi

Entry nameiPABP_YARLI
AccessioniPrimary (citable) accession number: Q6CDH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: August 16, 2004
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome