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Protein

Histone deacetylase

Gene

YALI0_C06061g

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118SubstrateUniRule annotation1
Active sitei160Proton acceptorUniRule annotation1
Binding sitei168Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi195Divalent metal cationUniRule annotation1
Metal bindingi197Divalent metal cationUniRule annotation1
Metal bindingi284Divalent metal cationUniRule annotation1
Binding sitei323SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:YALI0_C06061gImported
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)Imported
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi4952.XP_501501.1

Structurei

3D structure databases

ProteinModelPortaliQ6CCW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 338Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180
InParanoidiQ6CCW1
KOiK11483
OMAiPRAWTHL
OrthoDBiEOG092C1END

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CCW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPTIVFDS KTVENTPLYE SFLTTQKRRV SYHFNEEAAR YHYGVRHPMK
60 70 80 90 100
PFRLMLTDHL VLGYKLHNKL DLYRSRRATE TEVREFHAEE YIDFLQRVTP
110 120 130 140 150
DNIKKFQRVL PKFNIGDDCP IFDGMYDYSI IYAGSSLDAS RKLLAGQSDI
160 170 180 190 200
AINWSGGLHH AKKFEASGFC YVNDIVLAIL NLLRMYPRVL YIDIDIHHGD
210 220 230 240 250
GVQEAFYSTD RVMTLSFHKY NGEFFPGTGN FDEIGTSLGK NYSLNVPLRD
260 270 280 290 300
GIDDESYVRL FKSVLEPVLN SYRPSAIVLQ CGADSLGGDR LGCFNLNIKA
310 320 330 340 350
HGECVAYTKS FGLPLIVLGG GGYTPRNVSR LWCYETSVCL DVDLETRLPS
360 370 380 390 400
SMPFLKYFAP DYSLHPNLAG KIDNKNSRKF LDSVHVQVME QLRTLQGAPS
410 420 430
VQMAEIPPDL AGLTEEGEKQ RRDELDEAMK DAR
Length:433
Mass (Da):49,222
Last modified:August 16, 2004 - v1
Checksum:i169350AD6193A13B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA Translation: CAG81802.1
RefSeqiXP_501501.1, XM_501501.1

Genome annotation databases

EnsemblFungiiCAG81802; CAG81802; YALI0_C06061g
GeneIDi2909232
KEGGiyli:YALI0C06061g

Similar proteinsi

Entry informationi

Entry nameiQ6CCW1_YARLI
AccessioniPrimary (citable) accession number: Q6CCW1
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health