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Q6CCW0

- HEM1_YARLI

UniProt

Q6CCW0 - HEM1_YARLI

Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371SubstrateBy similarity
    Binding sitei251 – 2511SubstrateBy similarity
    Binding sitei270 – 2701SubstrateBy similarity
    Binding sitei303 – 3031Pyridoxal phosphateBy similarity
    Binding sitei331 – 3311Pyridoxal phosphateBy similarity
    Binding sitei373 – 3731Pyridoxal phosphateBy similarity
    Active sitei376 – 3761By similarity
    Binding sitei405 – 4051Pyridoxal phosphateBy similarity
    Binding sitei406 – 4061Pyridoxal phosphateBy similarity
    Binding sitei491 – 4911SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
    Alternative name(s):
    5-aminolevulinic acid synthase
    Delta-ALA synthase
    Delta-aminolevulinate synthase
    Gene namesi
    Name:HEM1
    Ordered Locus Names:YALI0C06083g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome C

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 5635-aminolevulinate synthase, mitochondrialPRO_0000001244
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei376 – 3761N6-(pyridoxal phosphate)lysineBy similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi4952.Q6CCW0.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CCW0.
    SMRiQ6CCW0. Positions 118-523.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0156.
    HOGENOMiHOG000221020.
    KOiK00643.
    OMAiERESASC.
    OrthoDBiEOG7HHX1P.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6CCW0-1 [UniParc]FASTAAdd to Basket

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    MESLVRQSKK LCPYIGRTSA SSLKQLGNGR LTQKAGQCPI MGKAMGVRGF    50
    KSDAGSNAES ATVDVHAAVD TSKGTCPHAA QYSPVYPSSR LDNYPFGMTQ 100
    RGLGKVPTQD AHNATTFNYE SFYENKINAK HQDKSYRYFN NINRLAAEFP 150
    RAHRGSIEED KVTVWCANDY LGMGRNPVVV DAMHETLDKY GAGAGGTRNI 200
    AGHNRHAVEL EAAIADLHKK EAALVFSSCY VANDSTLSLL GQALPNCVYF 250
    SDASNHASMI HGIRHGGSEK VVWKHNDLAD LEAKLARYPK STPKVIAFES 300
    VYSMCGSIGP IEEICDLADK YGAITFLDEV HAVGMYGPTG AGVAEHLDFE 350
    HYHSGAQTQR QPIMDRVDIF TGTLGKAYGC VGGYIAGSAK FVDMVRSYAP 400
    GFIFTTTLPP ATMAGARAAI NYQKATMKDR VAQQTHTRYV KDKLANRGIP 450
    VVPNPSHIVP VLVGDAQKAK AASDLLLTKH QIYVQAINFP TVPIGQERLR 500
    VTPTPGHHEG LCDELVAALE DVWQELDLKR VEDWTAEGGL CGVGEGVEVE 550
    PLWSEEQLSY GRD 563
    Length:563
    Mass (Da):61,237
    Last modified:August 16, 2004 - v1
    Checksum:iFC7BBC2F382C0170
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG81803.1.
    RefSeqiXP_501502.1. XM_501502.1.

    Genome annotation databases

    EnsemblFungiiCAG81803; CAG81803; YALI0_C06083g.
    GeneIDi2909236.
    KEGGiyli:YALI0C06083g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG81803.1 .
    RefSeqi XP_501502.1. XM_501502.1.

    3D structure databases

    ProteinModelPortali Q6CCW0.
    SMRi Q6CCW0. Positions 118-523.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CCW0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG81803 ; CAG81803 ; YALI0_C06083g .
    GeneIDi 2909236.
    KEGGi yli:YALI0C06083g.

    Phylogenomic databases

    eggNOGi COG0156.
    HOGENOMi HOG000221020.
    KOi K00643.
    OMAi ERESASC.
    OrthoDBi EOG7HHX1P.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiHEM1_YARLI
    AccessioniPrimary (citable) accession number: Q6CCW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3