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Q6CCW0

- HEM1_YARLI

UniProt

Q6CCW0 - HEM1_YARLI

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Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Binding sitei270 – 2701SubstrateBy similarity
Binding sitei303 – 3031Pyridoxal phosphateBy similarity
Binding sitei331 – 3311Pyridoxal phosphateBy similarity
Binding sitei373 – 3731Pyridoxal phosphateBy similarity
Active sitei376 – 3761By similarity
Binding sitei405 – 4051Pyridoxal phosphateBy similarity
Binding sitei406 – 4061Pyridoxal phosphateBy similarity
Binding sitei491 – 4911SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:YALI0C06083g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5635-aminolevulinate synthase, mitochondrialPRO_0000001244
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei376 – 3761N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CCW0.

Structurei

3D structure databases

ProteinModelPortaliQ6CCW0.
SMRiQ6CCW0. Positions 118-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
InParanoidiQ6CCW0.
KOiK00643.
OMAiERESASC.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CCW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLVRQSKK LCPYIGRTSA SSLKQLGNGR LTQKAGQCPI MGKAMGVRGF
60 70 80 90 100
KSDAGSNAES ATVDVHAAVD TSKGTCPHAA QYSPVYPSSR LDNYPFGMTQ
110 120 130 140 150
RGLGKVPTQD AHNATTFNYE SFYENKINAK HQDKSYRYFN NINRLAAEFP
160 170 180 190 200
RAHRGSIEED KVTVWCANDY LGMGRNPVVV DAMHETLDKY GAGAGGTRNI
210 220 230 240 250
AGHNRHAVEL EAAIADLHKK EAALVFSSCY VANDSTLSLL GQALPNCVYF
260 270 280 290 300
SDASNHASMI HGIRHGGSEK VVWKHNDLAD LEAKLARYPK STPKVIAFES
310 320 330 340 350
VYSMCGSIGP IEEICDLADK YGAITFLDEV HAVGMYGPTG AGVAEHLDFE
360 370 380 390 400
HYHSGAQTQR QPIMDRVDIF TGTLGKAYGC VGGYIAGSAK FVDMVRSYAP
410 420 430 440 450
GFIFTTTLPP ATMAGARAAI NYQKATMKDR VAQQTHTRYV KDKLANRGIP
460 470 480 490 500
VVPNPSHIVP VLVGDAQKAK AASDLLLTKH QIYVQAINFP TVPIGQERLR
510 520 530 540 550
VTPTPGHHEG LCDELVAALE DVWQELDLKR VEDWTAEGGL CGVGEGVEVE
560
PLWSEEQLSY GRD
Length:563
Mass (Da):61,237
Last modified:August 16, 2004 - v1
Checksum:iFC7BBC2F382C0170
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG81803.1.
RefSeqiXP_501502.1. XM_501502.1.

Genome annotation databases

EnsemblFungiiCAG81803; CAG81803; YALI0_C06083g.
GeneIDi2909236.
KEGGiyli:YALI0C06083g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG81803.1 .
RefSeqi XP_501502.1. XM_501502.1.

3D structure databases

ProteinModelPortali Q6CCW0.
SMRi Q6CCW0. Positions 118-523.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CCW0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG81803 ; CAG81803 ; YALI0_C06083g .
GeneIDi 2909236.
KEGGi yli:YALI0C06083g.

Phylogenomic databases

eggNOGi COG0156.
HOGENOMi HOG000221020.
InParanoidi Q6CCW0.
KOi K00643.
OMAi ERESASC.
OrthoDBi EOG7HHX1P.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHEM1_YARLI
AccessioniPrimary (citable) accession number: Q6CCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3