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Protein

5-aminolevulinate synthase, mitochondrial

Gene

HEM1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei137 – 1371SubstrateBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Binding sitei270 – 2701SubstrateBy similarity
Binding sitei303 – 3031Pyridoxal phosphateBy similarity
Binding sitei331 – 3311Pyridoxal phosphateBy similarity
Binding sitei373 – 3731Pyridoxal phosphateBy similarity
Active sitei376 – 3761By similarity
Binding sitei405 – 4051Pyridoxal phosphateBy similarity
Binding sitei406 – 4061Pyridoxal phosphateBy similarity
Binding sitei491 – 4911SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, mitochondrial (EC:2.3.1.37)
Alternative name(s):
5-aminolevulinic acid synthase
Delta-ALA synthase
Delta-aminolevulinate synthase
Gene namesi
Name:HEM1
Ordered Locus Names:YALI0C06083g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5635-aminolevulinate synthase, mitochondrialPRO_0000001244
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei376 – 3761N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi4952.Q6CCW0.

Structurei

3D structure databases

ProteinModelPortaliQ6CCW0.
SMRiQ6CCW0. Positions 118-523.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
InParanoidiQ6CCW0.
KOiK00643.
OMAiCHIFSDS.
OrthoDBiEOG7HHX1P.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6CCW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLVRQSKK LCPYIGRTSA SSLKQLGNGR LTQKAGQCPI MGKAMGVRGF
60 70 80 90 100
KSDAGSNAES ATVDVHAAVD TSKGTCPHAA QYSPVYPSSR LDNYPFGMTQ
110 120 130 140 150
RGLGKVPTQD AHNATTFNYE SFYENKINAK HQDKSYRYFN NINRLAAEFP
160 170 180 190 200
RAHRGSIEED KVTVWCANDY LGMGRNPVVV DAMHETLDKY GAGAGGTRNI
210 220 230 240 250
AGHNRHAVEL EAAIADLHKK EAALVFSSCY VANDSTLSLL GQALPNCVYF
260 270 280 290 300
SDASNHASMI HGIRHGGSEK VVWKHNDLAD LEAKLARYPK STPKVIAFES
310 320 330 340 350
VYSMCGSIGP IEEICDLADK YGAITFLDEV HAVGMYGPTG AGVAEHLDFE
360 370 380 390 400
HYHSGAQTQR QPIMDRVDIF TGTLGKAYGC VGGYIAGSAK FVDMVRSYAP
410 420 430 440 450
GFIFTTTLPP ATMAGARAAI NYQKATMKDR VAQQTHTRYV KDKLANRGIP
460 470 480 490 500
VVPNPSHIVP VLVGDAQKAK AASDLLLTKH QIYVQAINFP TVPIGQERLR
510 520 530 540 550
VTPTPGHHEG LCDELVAALE DVWQELDLKR VEDWTAEGGL CGVGEGVEVE
560
PLWSEEQLSY GRD
Length:563
Mass (Da):61,237
Last modified:August 16, 2004 - v1
Checksum:iFC7BBC2F382C0170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG81803.1.
RefSeqiXP_501502.1. XM_501502.1.

Genome annotation databases

EnsemblFungiiCAG81803; CAG81803; YALI0_C06083g.
GeneIDi2909236.
KEGGiyli:YALI0C06083g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG81803.1.
RefSeqiXP_501502.1. XM_501502.1.

3D structure databases

ProteinModelPortaliQ6CCW0.
SMRiQ6CCW0. Positions 118-523.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4952.Q6CCW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG81803; CAG81803; YALI0_C06083g.
GeneIDi2909236.
KEGGiyli:YALI0C06083g.

Phylogenomic databases

eggNOGiCOG0156.
HOGENOMiHOG000221020.
InParanoidiQ6CCW0.
KOiK00643.
OMAiCHIFSDS.
OrthoDBiEOG7HHX1P.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEM1_YARLI
AccessioniPrimary (citable) accession number: Q6CCW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.