Reviewed, UniProtKB/Swiss-Prot Q6CCU3 (MPG1_YARLI)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase
    GDP-mannose pyrophosphorylase

Gene names

Name:	MPG1
Ordered Locus Names:	YALI0C06490g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	363 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 363	363	Mannose-1-phosphate guanyltransferase		PRO_0000238494

Sequences

	Sequence		Length	Mass (Da)
	Q6CCU3-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 63D59D50107F3922	FASTA	363	39,767
	10 20 30 40 50 60 MKGLILVGGY GTRLRPLTLT LPKPLVEFGN KPMILHQVES LAAAGVKDIV LAVNYRPEVM 70 80 90 100 110 120 IETLKKYEEK YGVNITFSVE TEPLGTAGPL KLAEEILCKD DTPFFVLNSD VICDYPFAEL 130 140 150 160 170 180 AEFHKKNNAE ATIVATKVEE PSKYGVIVHK QGTSKIDRFV EKPVEFVGNR INAGIYILNP 190 200 210 220 230 240 SVVDLIDLRP TSIEKETFPQ LAARESLYSF DLEGYWMDVG QPKDFLSGTC LYLSSLSKKN 250 260 270 280 290 300 PEALVPTSEP YVTGGNVLVD PTAKISPQAK IGPNVVIGPG AVIGEGARLS RCVVLANSTI 310 320 330 340 350 360 KPHAFVKNSI IGWNGRVGRW ARIENVSVFG DDVEVKDEVY VNGGRVLPHK TISGNIEKPE IIM

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR382129 Genomic DNA. Translation: CAG81822.1.
RefSeq	XP_501519.1.
3D structure databases
SMR	Q6CCU3. Positions 1-237, 2-293, 3-339.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6CCU3.
Genome annotation databases
GeneID	2909316.
GenomeReviews	Gene locus YALI0C06490g in contig CR382129_GR.
KEGG	yli:YALI0C06490g.
Phylogenomic databases
eggNOG	fuNOG07401.
HOGENOM	HBG688195.
OMA	RRIQLQP.
OrthoDB	EOG9V70ZQ.
PhylomeDB	Q6CCU3.
Enzyme and pathway databases
BRENDA	2.7.7.13. 3602.
Family and domain databases
InterPro	IPR005835. NTP_transferase. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG1_YARLI

Accession

Primary (citable) accession number: Q6CCU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	August 16, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)