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Q6CCB0 (SSN3_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:YALI0C10967g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length405 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 405405Serine/threonine-protein kinase SSN3
PRO_0000312952

Regions

Domain40 – 350311Protein kinase
Nucleotide binding46 – 549ATP By similarity

Sites

Active site1731Proton acceptor By similarity
Binding site711ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6CCB0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 87531A9EF806F384

FASTA40546,290
        10         20         30         40         50         60 
MSNYRRGVGS YSRMLGGGTN PFAAYTARKA KTKKRVLDKY EIIGYIAAGT YGRVYKARSK 

        70         80         90        100        110        120 
DPGDTNQYAI KKFKADKEGE MVHYAGISQS ACREVALCAE LDNRNITKLV ETILEDTCIY 

       130        140        150        160        170        180 
MVFEYAEHDL LQIIHYHSHP ERKPIPEYTL KSILWQLLNG VSYLHQNWVL HRDLKPANTM 

       190        200        210        220        230        240 
VTSDGVLKIG DLGLARLFSN PLQSLYSGDK VVVTIWYRAP ELLLGARHYS PAVDLWAVGC 

       250        260        270        280        290        300 
IFAELLALRP IFKGEEAKMD NKTNVPFQRN QMQKIIEILG SPQEDDWPSL SKFPEYESLK 

       310        320        330        340        350        360 
QMKTFPPNLE AWYQSIGGTN QKGFQLLSRL LEYDPAKRLT ANDALLHPYF TEAPKVSQNV 

       370        380        390        400 
FERQEYKYPP RRISCEDSDI KTMTYQGTKR GSQGGDNLHP RKKQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382129 Genomic DNA. Translation: CAG82011.1.
RefSeqXP_501702.1. XM_501702.1.

3D structure databases

ProteinModelPortalQ6CCB0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CCB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82011; CAG82011; YALI0_C10967g.
GeneID2909134.
KEGGyli:YALI0C10967g.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02208.
OMARRVTHED.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_YARLI
AccessionPrimary (citable) accession number: Q6CCB0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families