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Q6CCB0

- SSN3_YARLI

UniProt

Q6CCB0 - SSN3_YARLI

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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711ATPPROSITE-ProRule annotation
Active sitei173 – 1731Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 549ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. metal ion binding Source: UniProtKB-KW
  4. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:YALI0C10967g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Serine/threonine-protein kinase SSN3PRO_0000312952Add
BLAST

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi4952.Q6CCB0.

Structurei

3D structure databases

ProteinModelPortaliQ6CCB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 350311Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ6CCB0.
KOiK02208.
OMAiRRVTHED.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CCB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNYRRGVGS YSRMLGGGTN PFAAYTARKA KTKKRVLDKY EIIGYIAAGT
60 70 80 90 100
YGRVYKARSK DPGDTNQYAI KKFKADKEGE MVHYAGISQS ACREVALCAE
110 120 130 140 150
LDNRNITKLV ETILEDTCIY MVFEYAEHDL LQIIHYHSHP ERKPIPEYTL
160 170 180 190 200
KSILWQLLNG VSYLHQNWVL HRDLKPANTM VTSDGVLKIG DLGLARLFSN
210 220 230 240 250
PLQSLYSGDK VVVTIWYRAP ELLLGARHYS PAVDLWAVGC IFAELLALRP
260 270 280 290 300
IFKGEEAKMD NKTNVPFQRN QMQKIIEILG SPQEDDWPSL SKFPEYESLK
310 320 330 340 350
QMKTFPPNLE AWYQSIGGTN QKGFQLLSRL LEYDPAKRLT ANDALLHPYF
360 370 380 390 400
TEAPKVSQNV FERQEYKYPP RRISCEDSDI KTMTYQGTKR GSQGGDNLHP

RKKQK
Length:405
Mass (Da):46,290
Last modified:August 16, 2004 - v1
Checksum:i87531A9EF806F384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82011.1.
RefSeqiXP_501702.1. XM_501702.1.

Genome annotation databases

EnsemblFungiiCAG82011; CAG82011; YALI0_C10967g.
GeneIDi2909134.
KEGGiyli:YALI0C10967g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82011.1 .
RefSeqi XP_501702.1. XM_501702.1.

3D structure databases

ProteinModelPortali Q6CCB0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CCB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82011 ; CAG82011 ; YALI0_C10967g .
GeneIDi 2909134.
KEGGi yli:YALI0C10967g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q6CCB0.
KOi K02208.
OMAi RRVTHED.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSSN3_YARLI
AccessioniPrimary (citable) accession number: Q6CCB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3