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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71ATPPROSITE-ProRule annotation1
Active sitei173Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 54ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:YALI0C10967g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129521 – 405Serine/threonine-protein kinase SSN3Add BLAST405

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi4952.XP_501702.1.

Structurei

3D structure databases

ProteinModelPortaliQ6CCB0.
SMRiQ6CCB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 350Protein kinasePROSITE-ProRule annotationAdd BLAST311

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024.
InParanoidiQ6CCB0.
KOiK02208.
OMAiFMVFEYA.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CCB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNYRRGVGS YSRMLGGGTN PFAAYTARKA KTKKRVLDKY EIIGYIAAGT
60 70 80 90 100
YGRVYKARSK DPGDTNQYAI KKFKADKEGE MVHYAGISQS ACREVALCAE
110 120 130 140 150
LDNRNITKLV ETILEDTCIY MVFEYAEHDL LQIIHYHSHP ERKPIPEYTL
160 170 180 190 200
KSILWQLLNG VSYLHQNWVL HRDLKPANTM VTSDGVLKIG DLGLARLFSN
210 220 230 240 250
PLQSLYSGDK VVVTIWYRAP ELLLGARHYS PAVDLWAVGC IFAELLALRP
260 270 280 290 300
IFKGEEAKMD NKTNVPFQRN QMQKIIEILG SPQEDDWPSL SKFPEYESLK
310 320 330 340 350
QMKTFPPNLE AWYQSIGGTN QKGFQLLSRL LEYDPAKRLT ANDALLHPYF
360 370 380 390 400
TEAPKVSQNV FERQEYKYPP RRISCEDSDI KTMTYQGTKR GSQGGDNLHP

RKKQK
Length:405
Mass (Da):46,290
Last modified:August 16, 2004 - v1
Checksum:i87531A9EF806F384
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA. Translation: CAG82011.1.
RefSeqiXP_501702.1. XM_501702.1.

Genome annotation databases

EnsemblFungiiCAG82011; CAG82011; YALI0_C10967g.
GeneIDi2909134.
KEGGiyli:YALI0C10967g.

Similar proteinsi

Entry informationi

Entry nameiSSN3_YARLI
AccessioniPrimary (citable) accession number: Q6CCB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families