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Q6CCB0

- SSN3_YARLI

UniProt

Q6CCB0 - SSN3_YARLI

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Protein
Serine/threonine-protein kinase SSN3
Gene
SSN3, CDK8, YALI0C10967g
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei71 – 711ATP By similarity
Active sitei173 – 1731Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 549ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:YALI0C10967g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Serine/threonine-protein kinase SSN3
PRO_0000312952Add
BLAST

Interactioni

Subunit structurei

Component of the srb8-11 complex, a regulatory module of the Mediator complex By similarity.

Protein-protein interaction databases

STRINGi4952.Q6CCB0.

Structurei

3D structure databases

ProteinModelPortaliQ6CCB0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 350311Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK02208.
OMAiRRVTHED.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6CCB0-1 [UniParc]FASTAAdd to Basket

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MSNYRRGVGS YSRMLGGGTN PFAAYTARKA KTKKRVLDKY EIIGYIAAGT    50
YGRVYKARSK DPGDTNQYAI KKFKADKEGE MVHYAGISQS ACREVALCAE 100
LDNRNITKLV ETILEDTCIY MVFEYAEHDL LQIIHYHSHP ERKPIPEYTL 150
KSILWQLLNG VSYLHQNWVL HRDLKPANTM VTSDGVLKIG DLGLARLFSN 200
PLQSLYSGDK VVVTIWYRAP ELLLGARHYS PAVDLWAVGC IFAELLALRP 250
IFKGEEAKMD NKTNVPFQRN QMQKIIEILG SPQEDDWPSL SKFPEYESLK 300
QMKTFPPNLE AWYQSIGGTN QKGFQLLSRL LEYDPAKRLT ANDALLHPYF 350
TEAPKVSQNV FERQEYKYPP RRISCEDSDI KTMTYQGTKR GSQGGDNLHP 400
RKKQK 405
Length:405
Mass (Da):46,290
Last modified:August 16, 2004 - v1
Checksum:i87531A9EF806F384
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG82011.1.
RefSeqiXP_501702.1. XM_501702.1.

Genome annotation databases

EnsemblFungiiCAG82011; CAG82011; YALI0_C10967g.
GeneIDi2909134.
KEGGiyli:YALI0C10967g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG82011.1 .
RefSeqi XP_501702.1. XM_501702.1.

3D structure databases

ProteinModelPortali Q6CCB0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 4952.Q6CCB0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82011 ; CAG82011 ; YALI0_C10967g .
GeneIDi 2909134.
KEGGi yli:YALI0C10967g.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K02208.
OMAi RRVTHED.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiSSN3_YARLI
AccessioniPrimary (citable) accession number: Q6CCB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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