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Q6CC99 (HAT1_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase type B catalytic subunit

EC=2.3.1.48
Gene names
Name:HAT1
Ordered Locus Names:YALI0C11231g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the HAT1 family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
Nucleus
   Molecular functionAcyltransferase
Chromatin regulator
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

chromatin silencing at telomere

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

histone acetyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 451451Histone acetyltransferase type B catalytic subunit
PRO_0000227728

Sequences

Sequence LengthMass (Da)Tools
Q6CC99 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 6D491A9BF98D7133

FASTA45152,089
        10         20         30         40         50         60 
MDIATEWTTN ANEALTITLE PSKGKGKGKE VSNGSEKSHV FNPIFTYPIY GDVETILGYK 

        70         80         90        100        110        120 
NFELNLKMDA STMLPLVTVK FSDKLEFDGI SFDDPVERLL EFLPEETATD EAEWEEKRVK 

       130        140        150        160        170        180 
ELGDGFKPVG KEFGTFSVNS EKYTVHRSTL LDPETLKLHL RLQIFVPLFI EAGSYIDNED 

       190        200        210        220        230        240 
DRWEIYIVYN AEKEIVGFST VYCYWFYEPS AKESKAPKDA SLEQLQKQPF SPTLRKRISQ 

       250        260        270        280        290        300 
YVILPPFQGK GLGGQLYTLL FSRFYADPNV YEITVEDPSE AFDDLRDRCD LKWLADQGFP 

       310        320        330        340        350        360 
SEVFRMLQTT SAHGEKAGDN RTGRTKVVAG AFWTKWLEEH RLKYKLAHRQ FARCFEMILL 

       370        380        390        400        410        420 
ACLEVSSPTK KRNIKDARLF IKKRVYVRNR EFLEELGGKI EVMSKLQETY ESMEEDYARI 

       430        440        450 
MKPVLGYVKD GLKKRDRNDA GNEEAKRVKV E 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR382129 Genomic DNA. Translation: CAG82023.1.
RefSeqXP_501713.1. XM_501713.1.

3D structure databases

ProteinModelPortalQ6CC99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.Q6CC99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG82023; CAG82023; YALI0_C11231g.
GeneID2909147.
KEGGyli:YALI0C11231g.

Phylogenomic databases

eggNOGNOG326277.
HOGENOMHOG000074728.
KOK11303.
OMAHISYDEK.
OrthoDBEOG7HTHSD.

Family and domain databases

Gene3D1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERPTHR12046. PTHR12046. 1 hit.
PfamPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMSSF55729. SSF55729. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHAT1_YARLI
AccessionPrimary (citable) accession number: Q6CC99
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: November 13, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families