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Q6CC99

- HAT1_YARLI

UniProt

Q6CC99 - HAT1_YARLI

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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei183 – 1831Interaction with histone H4 N-terminusBy similarity
Active sitei276 – 2761Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
Ordered Locus Names:YALI0C11231g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
ProteomesiUP000001300: Chromosome C

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Histone acetyltransferase type B catalytic subunitPRO_0000227728Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Protein-protein interaction databases

STRINGi4952.Q6CC99.

Structurei

3D structure databases

ProteinModelPortaliQ6CC99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 543Interaction with histone H4 N-terminusBy similarity
Regioni202 – 2043Interaction with histone H4 N-terminusBy similarity
Regioni241 – 2433Acetyl-CoA bindingBy similarity
Regioni248 – 2547Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

eggNOGiNOG326277.
HOGENOMiHOG000074728.
InParanoidiQ6CC99.
KOiK11303.
OMAiHISYDEK.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6CC99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIATEWTTN ANEALTITLE PSKGKGKGKE VSNGSEKSHV FNPIFTYPIY
60 70 80 90 100
GDVETILGYK NFELNLKMDA STMLPLVTVK FSDKLEFDGI SFDDPVERLL
110 120 130 140 150
EFLPEETATD EAEWEEKRVK ELGDGFKPVG KEFGTFSVNS EKYTVHRSTL
160 170 180 190 200
LDPETLKLHL RLQIFVPLFI EAGSYIDNED DRWEIYIVYN AEKEIVGFST
210 220 230 240 250
VYCYWFYEPS AKESKAPKDA SLEQLQKQPF SPTLRKRISQ YVILPPFQGK
260 270 280 290 300
GLGGQLYTLL FSRFYADPNV YEITVEDPSE AFDDLRDRCD LKWLADQGFP
310 320 330 340 350
SEVFRMLQTT SAHGEKAGDN RTGRTKVVAG AFWTKWLEEH RLKYKLAHRQ
360 370 380 390 400
FARCFEMILL ACLEVSSPTK KRNIKDARLF IKKRVYVRNR EFLEELGGKI
410 420 430 440 450
EVMSKLQETY ESMEEDYARI MKPVLGYVKD GLKKRDRNDA GNEEAKRVKV

E
Length:451
Mass (Da):52,089
Last modified:August 16, 2004 - v1
Checksum:i6D491A9BF98D7133
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG82023.1.
RefSeqiXP_501713.1. XM_501713.1.

Genome annotation databases

EnsemblFungiiCAG82023; CAG82023; YALI0_C11231g.
GeneIDi2909147.
KEGGiyli:YALI0C11231g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR382129 Genomic DNA. Translation: CAG82023.1 .
RefSeqi XP_501713.1. XM_501713.1.

3D structure databases

ProteinModelPortali Q6CC99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 4952.Q6CC99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CAG82023 ; CAG82023 ; YALI0_C11231g .
GeneIDi 2909147.
KEGGi yli:YALI0C11231g.

Phylogenomic databases

eggNOGi NOG326277.
HOGENOMi HOG000074728.
InParanoidi Q6CC99.
KOi K11303.
OMAi HISYDEK.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHAT1_YARLI
AccessioniPrimary (citable) accession number: Q6CC99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3