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Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei276Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
Ordered Locus Names:YALI0C11231g
OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Taxonomic identifieri284591 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
Proteomesi
  • UP000001300 Componenti: Chromosome C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002277281 – 451Histone acetyltransferase type B catalytic subunitAdd BLAST451

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei183Interaction with histone H4 N-terminusBy similarity1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4952.XP_501713.1

Structurei

3D structure databases

ProteinModelPortaliQ6CC99
SMRiQ6CC99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Interaction with histone H4 N-terminusBy similarity3
Regioni202 – 204Interaction with histone H4 N-terminusBy similarity3
Regioni241 – 243Acetyl-CoA bindingBy similarity3
Regioni248 – 254Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the HAT1 family.Curated

Phylogenomic databases

HOGENOMiHOG000074728
InParanoidiQ6CC99
KOiK11303
OMAiMAHQIFG
OrthoDBiEOG092C3YYH

Family and domain databases

Gene3Di3.90.360.10, 2 hits
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR019467 Hat1_N
IPR037113 Hat1_N_sf
IPR017380 Hist_AcTrfase_B-typ_cat-su
PANTHERiPTHR12046 PTHR12046, 1 hit
PfamiView protein in Pfam
PF10394 Hat1_N, 1 hit
PIRSFiPIRSF038084 HAT-B_cat, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

Sequencei

Sequence statusi: Complete.

Q6CC99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIATEWTTN ANEALTITLE PSKGKGKGKE VSNGSEKSHV FNPIFTYPIY
60 70 80 90 100
GDVETILGYK NFELNLKMDA STMLPLVTVK FSDKLEFDGI SFDDPVERLL
110 120 130 140 150
EFLPEETATD EAEWEEKRVK ELGDGFKPVG KEFGTFSVNS EKYTVHRSTL
160 170 180 190 200
LDPETLKLHL RLQIFVPLFI EAGSYIDNED DRWEIYIVYN AEKEIVGFST
210 220 230 240 250
VYCYWFYEPS AKESKAPKDA SLEQLQKQPF SPTLRKRISQ YVILPPFQGK
260 270 280 290 300
GLGGQLYTLL FSRFYADPNV YEITVEDPSE AFDDLRDRCD LKWLADQGFP
310 320 330 340 350
SEVFRMLQTT SAHGEKAGDN RTGRTKVVAG AFWTKWLEEH RLKYKLAHRQ
360 370 380 390 400
FARCFEMILL ACLEVSSPTK KRNIKDARLF IKKRVYVRNR EFLEELGGKI
410 420 430 440 450
EVMSKLQETY ESMEEDYARI MKPVLGYVKD GLKKRDRNDA GNEEAKRVKV

E
Length:451
Mass (Da):52,089
Last modified:August 16, 2004 - v1
Checksum:i6D491A9BF98D7133
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR382129 Genomic DNA Translation: CAG82023.1
RefSeqiXP_501713.1, XM_501713.1

Genome annotation databases

EnsemblFungiiCAG82023; CAG82023; YALI0_C11231g
GeneIDi2909147
KEGGiyli:YALI0C11231g

Similar proteinsi

Entry informationi

Entry nameiHAT1_YARLI
AccessioniPrimary (citable) accession number: Q6CC99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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