Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6CC99

- HAT1_YARLI

UniProt

Q6CC99 - HAT1_YARLI

Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chromatin silencing at telomere Source: InterPro
    2. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48)
    Gene namesi
    Name:HAT1
    Ordered Locus Names:YALI0C11231g
    OrganismiYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
    Taxonomic identifieri284591 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia
    ProteomesiUP000001300: Chromosome C

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. histone acetyltransferase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 451451Histone acetyltransferase type B catalytic subunitPRO_0000227728Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity.By similarity

    Protein-protein interaction databases

    STRINGi4952.Q6CC99.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6CC99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAT1 family.Curated

    Phylogenomic databases

    eggNOGiNOG326277.
    HOGENOMiHOG000074728.
    KOiK11303.
    OMAiHISYDEK.
    OrthoDBiEOG7HTHSD.

    Family and domain databases

    Gene3Di1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view]
    PANTHERiPTHR12046. PTHR12046. 1 hit.
    PfamiPF10394. Hat1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMiSSF55729. SSF55729. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6CC99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIATEWTTN ANEALTITLE PSKGKGKGKE VSNGSEKSHV FNPIFTYPIY    50
    GDVETILGYK NFELNLKMDA STMLPLVTVK FSDKLEFDGI SFDDPVERLL 100
    EFLPEETATD EAEWEEKRVK ELGDGFKPVG KEFGTFSVNS EKYTVHRSTL 150
    LDPETLKLHL RLQIFVPLFI EAGSYIDNED DRWEIYIVYN AEKEIVGFST 200
    VYCYWFYEPS AKESKAPKDA SLEQLQKQPF SPTLRKRISQ YVILPPFQGK 250
    GLGGQLYTLL FSRFYADPNV YEITVEDPSE AFDDLRDRCD LKWLADQGFP 300
    SEVFRMLQTT SAHGEKAGDN RTGRTKVVAG AFWTKWLEEH RLKYKLAHRQ 350
    FARCFEMILL ACLEVSSPTK KRNIKDARLF IKKRVYVRNR EFLEELGGKI 400
    EVMSKLQETY ESMEEDYARI MKPVLGYVKD GLKKRDRNDA GNEEAKRVKV 450
    E 451
    Length:451
    Mass (Da):52,089
    Last modified:August 16, 2004 - v1
    Checksum:i6D491A9BF98D7133
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG82023.1.
    RefSeqiXP_501713.1. XM_501713.1.

    Genome annotation databases

    EnsemblFungiiCAG82023; CAG82023; YALI0_C11231g.
    GeneIDi2909147.
    KEGGiyli:YALI0C11231g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR382129 Genomic DNA. Translation: CAG82023.1 .
    RefSeqi XP_501713.1. XM_501713.1.

    3D structure databases

    ProteinModelPortali Q6CC99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 4952.Q6CC99.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CAG82023 ; CAG82023 ; YALI0_C11231g .
    GeneIDi 2909147.
    KEGGi yli:YALI0C11231g.

    Phylogenomic databases

    eggNOGi NOG326277.
    HOGENOMi HOG000074728.
    KOi K11303.
    OMAi HISYDEK.
    OrthoDBi EOG7HTHSD.

    Family and domain databases

    Gene3Di 1.10.10.390. 1 hit.
    3.40.630.30. 1 hit.
    3.90.360.10. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR019467. Hat1_N.
    IPR017380. Hist_AcTrfase_B-typ_cat-su.
    IPR013523. Hist_AcTrfase_HAT1_C.
    [Graphical view ]
    PANTHERi PTHR12046. PTHR12046. 1 hit.
    Pfami PF10394. Hat1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
    SUPFAMi SSF55729. SSF55729. 1 hit.
    ProtoNeti Search...

    Entry informationi

    Entry nameiHAT1_YARLI
    AccessioniPrimary (citable) accession number: Q6CC99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3