Q6CC99 (HAT1_YARLI) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Histone acetyltransferase type B catalytic subunit EC=2.3.1.48 | ||||
| Gene names |
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| Organism | Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome] | ||||
| Taxonomic identifier | 284591 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia › ![]() |
Protein attributes
| Sequence length | 451 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair By similarity. |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subunit structure | Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the HAT1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair |
| Cellular component | Cytoplasm Nucleus |
| Molecular function | Acyltransferase Chromatin regulator Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin silencing at telomereInferred from electronic annotation. Source: InterPro |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell histone acetyltransferase complexInferred from electronic annotation. Source: InterPro |
| Molecular_function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 451 | 451 | Histone acetyltransferase type B catalytic subunit | PRO_0000227728 | |||
Sequences
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References
| [1] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR382129 Genomic DNA. Translation: CAG82023.1. |
| RefSeq | XP_501713.1. XM_501713.1. |
3D structure databases | |
| ProteinModelPortal | Q6CC99. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 4952.Q6CC99. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2909147. |
| KEGG | yli:YALI0C11231g. |
Phylogenomic databases | |
| eggNOG | NOG326277. |
| HOGENOM | HOG000074728. |
| KO | K11303. |
| OMA | ETIYGYE. |
| OrthoDB | EOG4G7G7K. |
Family and domain databases | |
| Gene3D | 1.10.10.390. 1 hit. 3.40.630.30. 1 hit. 3.90.360.10. 1 hit. |
| InterPro | IPR016181. Acyl_CoA_acyltransferase. IPR019467. Hat1_N. IPR017380. Hist_AcTrfase_B-typ_cat-su. IPR013523. Hist_AcTrfase_HAT1_C. [Graphical view] |
| PANTHER | PTHR12046. PTHR12046. 1 hit. |
| Pfam | PF10394. Hat1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF038084. HAT-B_cat. 1 hit. |
| SUPFAM | SSF55729. Acyl_CoA_acyltransferase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HAT1_YARLI | ||||||||
| Accession | Primary (citable) accession number: Q6CC99 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
